CH681891A5 - - Google Patents

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Publication number
CH681891A5
CH681891A5 CH3159/91A CH315991A CH681891A5 CH 681891 A5 CH681891 A5 CH 681891A5 CH 3159/91 A CH3159/91 A CH 3159/91A CH 315991 A CH315991 A CH 315991A CH 681891 A5 CH681891 A5 CH 681891A5
Authority
CH
Switzerland
Prior art keywords
acid
formulas
ester
bis
methyl
Prior art date
Application number
CH3159/91A
Other languages
German (de)
English (en)
Inventor
Carl Dr Eugster
Conrad Hans Prof Dr Eugster
Walter Dr Haldemann
Giorgio Prof Dr Rivara
Giuseppe Prof Dr Zina
Original Assignee
Marigen Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marigen Sa filed Critical Marigen Sa
Priority to CH3159/91A priority Critical patent/CH681891A5/de
Priority to DE4319492A priority patent/DE4319492A1/de
Publication of CH681891A5 publication Critical patent/CH681891A5/de
Priority to GB9400882A priority patent/GB2285805A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CH3159/91A 1992-10-09 1992-10-09 CH681891A5 (no)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CH3159/91A CH681891A5 (no) 1992-10-09 1992-10-09
DE4319492A DE4319492A1 (de) 1992-10-09 1993-06-11 Dicarbonsäureester
GB9400882A GB2285805A (en) 1992-10-09 1994-01-18 Esters

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH3159/91A CH681891A5 (no) 1992-10-09 1992-10-09
GB9400882A GB2285805A (en) 1992-10-09 1994-01-18 Esters

Publications (1)

Publication Number Publication Date
CH681891A5 true CH681891A5 (no) 1993-06-15

Family

ID=25692340

Family Applications (1)

Application Number Title Priority Date Filing Date
CH3159/91A CH681891A5 (no) 1992-10-09 1992-10-09

Country Status (3)

Country Link
CH (1) CH681891A5 (no)
DE (1) DE4319492A1 (no)
GB (1) GB2285805A (no)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2285805A (en) * 1992-10-09 1995-07-26 Marigen Sa Esters
US5593691A (en) * 1993-06-03 1997-01-14 Marigen S.A. Biotenside solvents for pharmaceuticals and cosmetics
WO1999015546A1 (en) * 1997-09-09 1999-04-01 Raisio Benecol Ltd. Use of organic acid esters in dietary fat
EP0946485A2 (en) * 1996-11-12 1999-10-06 Tamarkin Pharmaceutical Innovation Ltd. Method for treatment of dermatological disorders
DE102013215580A1 (de) * 2013-08-07 2015-02-12 Orgentec Diagnostika Gmbh 25-OH Vitamin D Derivate zur Bestimmung von Vitamin D Metaboliten
CN104434927A (zh) * 2014-12-16 2015-03-25 吉林农业大学 丙二酸双环戊烷并多氢菲酯b在制备降血压药物中的应用

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6394230B1 (en) 1997-12-16 2002-05-28 Cognis Corporation Sterol esters as food additives
US5892068A (en) * 1998-08-25 1999-04-06 Mcneil-Ppc, Inc. Preparation of sterol and stanol-esters
FR2829762B1 (fr) * 2001-09-17 2004-02-13 Fabre Pierre Dermo Cosmetique Bioprecurseurs destines a une application percutanee
CN102123763B (zh) 2008-08-19 2014-10-08 什诺波特有限公司 富马酸氢甲酯的前体药物、其药物组合物、及其使用方法
WO2014031844A1 (en) 2012-08-22 2014-02-27 Xenoport, Inc. Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
JP2015526477A (ja) 2012-08-22 2015-09-10 ゼノポート，インコーポレイティド メチル水素フマレートの経口剤形およびそのプロドラッグ
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
CN105452213B (zh) 2013-03-14 2017-09-22 阿尔克梅斯制药爱尔兰有限公司 富马酸酯前体药物及其在治疗多种疾病中的应用
WO2014160633A1 (en) 2013-03-24 2014-10-02 Xenoport, Inc. Pharmaceutical compositions of dimethyl fumarate
WO2014197860A1 (en) 2013-06-07 2014-12-11 Xenoport, Inc. Method of making monomethyl fumarate
US9421182B2 (en) 2013-06-21 2016-08-23 Xenoport, Inc. Cocrystals of dimethyl fumarate
US9416096B2 (en) 2013-09-06 2016-08-16 Xenoport, Inc. Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use
ES2753361T3 (es) 2014-02-24 2020-04-08 Alkermes Pharma Ireland Ltd Sulfonamida y profármacos de fumaratos de sulfinamida y su uso en el tratamiento de diversas enfermedades
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB760346A (en) * 1952-12-18 1956-10-31 Roche Products Ltd Novel esters of bixins and norbixins and process for the manufacture thereof
DE3672270D1 (de) * 1985-03-06 1990-08-02 Yoshikawa Oil & Fat Verfahren zur herstellung von fettsaeureestern.
US5198432A (en) * 1988-01-29 1993-03-30 Center For Innovative Technology Method of preventing chlorohydrocarbon toxicity using sterol derivatives
CH681891A5 (no) * 1992-10-09 1993-06-15 Marigen Sa

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2285805A (en) * 1992-10-09 1995-07-26 Marigen Sa Esters
US5593691A (en) * 1993-06-03 1997-01-14 Marigen S.A. Biotenside solvents for pharmaceuticals and cosmetics
EP0946485A2 (en) * 1996-11-12 1999-10-06 Tamarkin Pharmaceutical Innovation Ltd. Method for treatment of dermatological disorders
WO1999015546A1 (en) * 1997-09-09 1999-04-01 Raisio Benecol Ltd. Use of organic acid esters in dietary fat
WO1999015547A1 (en) * 1997-09-09 1999-04-01 Raisio Benecol Ltd. Use of organic acid esters in food products
US6441206B1 (en) 1997-09-09 2002-08-27 Raisio Benecol Ltd. Use of organic acid esters in dietary fat
DE102013215580A1 (de) * 2013-08-07 2015-02-12 Orgentec Diagnostika Gmbh 25-OH Vitamin D Derivate zur Bestimmung von Vitamin D Metaboliten
US10222388B2 (en) 2013-08-07 2019-03-05 Orgentec Diagnostika Gmbh 25-OH vitamin D derivatives for determining vitamin D metabolites
US11199553B2 (en) 2013-08-07 2021-12-14 Orgentec Diagnostika Gmbh 25-OH vitamin D derivatives for determining vitamin D metabolites
CN104434927A (zh) * 2014-12-16 2015-03-25 吉林农业大学 丙二酸双环戊烷并多氢菲酯b在制备降血压药物中的应用

Also Published As

Publication number Publication date
GB2285805A (en) 1995-07-26
DE4319492A1 (de) 1994-04-14
GB9400882D0 (en) 1994-03-16

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