CH680192A5 - - Google Patents
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- Publication number
- CH680192A5 CH680192A5 CH4484/89A CH448489A CH680192A5 CH 680192 A5 CH680192 A5 CH 680192A5 CH 4484/89 A CH4484/89 A CH 4484/89A CH 448489 A CH448489 A CH 448489A CH 680192 A5 CH680192 A5 CH 680192A5
- Authority
- CH
- Switzerland
- Prior art keywords
- lysozyme
- culture
- bulgaricus
- cells
- rennet
- Prior art date
Links
- 102000016943 Muramidase Human genes 0.000 claims abstract description 47
- 108010014251 Muramidase Proteins 0.000 claims abstract description 47
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims abstract description 47
- 229960000274 lysozyme Drugs 0.000 claims abstract description 47
- 235000010335 lysozyme Nutrition 0.000 claims abstract description 47
- 239000004325 lysozyme Substances 0.000 claims abstract description 47
- 230000003308 immunostimulating effect Effects 0.000 claims abstract description 21
- 241000894006 Bacteria Species 0.000 claims abstract description 20
- 239000005862 Whey Substances 0.000 claims abstract description 13
- 102000007544 Whey Proteins Human genes 0.000 claims abstract description 13
- 108010046377 Whey Proteins Proteins 0.000 claims abstract description 13
- 235000015140 cultured milk Nutrition 0.000 claims abstract description 11
- 210000002421 cell wall Anatomy 0.000 claims abstract description 8
- 241000186672 Lactobacillus delbrueckii subsp. bulgaricus Species 0.000 claims abstract 5
- 239000003795 chemical substances by application Substances 0.000 claims description 28
- 210000004027 cell Anatomy 0.000 claims description 22
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 20
- 229940108461 rennet Drugs 0.000 claims description 19
- 108010058314 rennet Proteins 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 17
- 230000007062 hydrolysis Effects 0.000 claims description 11
- 238000006460 hydrolysis reaction Methods 0.000 claims description 11
- 235000014655 lactic acid Nutrition 0.000 claims description 10
- 239000004310 lactic acid Substances 0.000 claims description 10
- 235000013960 Lactobacillus bulgaricus Nutrition 0.000 claims description 9
- 229940004208 lactobacillus bulgaricus Drugs 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 8
- 230000008569 process Effects 0.000 claims description 8
- 244000005700 microbiome Species 0.000 claims description 7
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 claims description 5
- 102000002322 Egg Proteins Human genes 0.000 claims description 5
- 108010000912 Egg Proteins Proteins 0.000 claims description 5
- 235000020247 cow milk Nutrition 0.000 claims description 5
- 235000014103 egg white Nutrition 0.000 claims description 5
- 210000000969 egg white Anatomy 0.000 claims description 5
- 239000001963 growth medium Substances 0.000 claims description 5
- 230000028993 immune response Effects 0.000 claims description 5
- 230000004936 stimulating effect Effects 0.000 claims description 4
- 241000588724 Escherichia coli Species 0.000 claims description 3
- 230000000369 enteropathogenic effect Effects 0.000 claims description 2
- 238000011081 inoculation Methods 0.000 claims description 2
- 239000000047 product Substances 0.000 abstract description 15
- 235000013336 milk Nutrition 0.000 abstract description 7
- 239000008267 milk Substances 0.000 abstract description 7
- 210000004080 milk Anatomy 0.000 abstract description 7
- 239000000725 suspension Substances 0.000 abstract description 7
- 229960001438 immunostimulant agent Drugs 0.000 abstract description 6
- 239000003022 immunostimulating agent Substances 0.000 abstract description 6
- 239000006228 supernatant Substances 0.000 abstract description 3
- 244000199885 Lactobacillus bulgaricus Species 0.000 description 22
- 241000699670 Mus sp. Species 0.000 description 11
- 229960005486 vaccine Drugs 0.000 description 10
- 235000013618 yogurt Nutrition 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 230000000968 intestinal effect Effects 0.000 description 5
- 241000194020 Streptococcus thermophilus Species 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000011218 seed culture Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 230000002349 favourable effect Effects 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 238000002627 tracheal intubation Methods 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 230000000378 dietary effect Effects 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000006872 mrs medium Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002028 Biomass Substances 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 102000009016 Cholera Toxin Human genes 0.000 description 1
- 108010049048 Cholera Toxin Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 101001091385 Homo sapiens Kallikrein-6 Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102100034866 Kallikrein-6 Human genes 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 241000282849 Ruminantia Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 230000003217 anti-cancerogenic effect Effects 0.000 description 1
- 239000003005 anticarcinogenic agent Substances 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- NLNLFIQELFXBSN-UHFFFAOYSA-M azanium;sodium;3-carboxy-3-hydroxypentanedioate Chemical compound [NH4+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O NLNLFIQELFXBSN-UHFFFAOYSA-M 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 210000004251 human milk Anatomy 0.000 description 1
- 235000020256 human milk Nutrition 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 229910000357 manganese(II) sulfate Inorganic materials 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 239000003531 protein hydrolysate Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/335—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Lactobacillus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/5555—Muramyl dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Dairy Products (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH4484/89A CH680192A5 (en, 2012) | 1989-12-13 | 1989-12-13 | |
| DE69022005T DE69022005T3 (de) | 1989-12-13 | 1990-11-14 | Immunostimulierendes Mittel. |
| ES90121752T ES2076280T5 (es) | 1989-12-13 | 1990-11-14 | Agente inmunoestimulante. |
| EP90121752A EP0432490B2 (fr) | 1989-12-13 | 1990-11-14 | Agent immunostimulant |
| DK90121752T DK0432490T4 (da) | 1989-12-13 | 1990-11-14 | Immunostimulerende middel |
| AT90121752T ATE127023T1 (de) | 1989-12-13 | 1990-11-14 | Immunostimulierendes mittel. |
| AU67021/90A AU643728B2 (en) | 1989-12-13 | 1990-11-27 | Immunomodulation |
| CA002030951A CA2030951C (en) | 1989-12-13 | 1990-11-27 | Process for producing immunostimulant agents |
| US07/619,119 US5185321A (en) | 1989-12-13 | 1990-11-27 | Process for producing immunostimulants |
| NZ236295A NZ236295A (en) | 1989-12-13 | 1990-11-30 | Immunostimulant containing n-acetyl muramylpeptides derived from cell walls of lactic acid bacteria using lysozyme |
| IE432390A IE68244B1 (en) | 1989-12-13 | 1990-11-30 | Immunomodulation |
| ZA909658A ZA909658B (en) | 1989-12-13 | 1990-11-30 | Immunomodulation |
| NO19905228A NO310498B1 (no) | 1989-12-13 | 1990-12-03 | Fremgangsmåte for fremstilling av et immunstimuleringsmiddel |
| MX023693A MX172984B (es) | 1989-12-13 | 1990-12-11 | Agente inmunoestimulante |
| PT96167A PT96167B (pt) | 1989-12-13 | 1990-12-12 | Processo para a preparacao de um agente imunoestimulante compreendendo derivados de n-acetil-muramil-peptidos |
| JP2402041A JP2595133B2 (ja) | 1989-12-13 | 1990-12-13 | 免疫刺激剤およびその製造法 |
| GR950402553T GR3017428T3 (en) | 1989-12-13 | 1995-09-18 | Immunostimulant agent. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH4484/89A CH680192A5 (en, 2012) | 1989-12-13 | 1989-12-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH680192A5 true CH680192A5 (en, 2012) | 1992-07-15 |
Family
ID=4276966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH4484/89A CH680192A5 (en, 2012) | 1989-12-13 | 1989-12-13 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5185321A (en, 2012) |
| EP (1) | EP0432490B2 (en, 2012) |
| JP (1) | JP2595133B2 (en, 2012) |
| AT (1) | ATE127023T1 (en, 2012) |
| AU (1) | AU643728B2 (en, 2012) |
| CA (1) | CA2030951C (en, 2012) |
| CH (1) | CH680192A5 (en, 2012) |
| DE (1) | DE69022005T3 (en, 2012) |
| DK (1) | DK0432490T4 (en, 2012) |
| ES (1) | ES2076280T5 (en, 2012) |
| GR (1) | GR3017428T3 (en, 2012) |
| IE (1) | IE68244B1 (en, 2012) |
| MX (1) | MX172984B (en, 2012) |
| NO (1) | NO310498B1 (en, 2012) |
| NZ (1) | NZ236295A (en, 2012) |
| PT (1) | PT96167B (en, 2012) |
| ZA (1) | ZA909658B (en, 2012) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6244094A (en) * | 1993-02-24 | 1994-09-14 | Sherwood L. Gorbach | Method of enhancing immune response to oral vaccines |
| US5741494A (en) * | 1993-04-07 | 1998-04-21 | Eisai Co., Ltd. | Immunopotentiative and infection-protective agent containing bacillus and egg white |
| US6348346B1 (en) | 1994-05-27 | 2002-02-19 | University Of Kentucky Research Foundation | Method of inhibiting binding activity of immunoglobulins |
| DE19619505C2 (de) * | 1996-05-14 | 1998-03-26 | Zyma Gmbh | Milch/Bakterienlysat zur Herstellung von Kosmetika und Arzneimitteln |
| GB9822619D0 (en) * | 1998-10-19 | 1998-12-09 | Porter William L | Immune response stimulation |
| US6641808B1 (en) | 1999-09-22 | 2003-11-04 | Lacpro Industries, Llc | Composition for treatment of obesity |
| US20040166101A1 (en) * | 1999-09-22 | 2004-08-26 | Bojrab Gregory G. | Enchanced composition for treatment of gastrointestinal disorders and hyperlipidemia |
| US6696057B1 (en) | 1999-09-22 | 2004-02-24 | Lacpro Industries, Inc. | Composition and method for treatment of gastrointestinal disorders and hyperlipidemia |
| US6827940B1 (en) | 2000-05-25 | 2004-12-07 | Aidan Products, Llc | Immune-stimulating bacterial cell wall extracts |
| US7655248B2 (en) * | 2000-06-19 | 2010-02-02 | Hunter Immunology Limited | Compositions and methods for treatment of candidiasis |
| GB0027761D0 (en) * | 2000-11-14 | 2000-12-27 | Nestle Sa | Nutritional composition for an immune condition |
| US20040258779A1 (en) * | 2003-06-06 | 2004-12-23 | Pinegrin Boris V. | Dietary and pharmaceutical compositions for treatment of anemia, thrombocytopenia, and leukopenia |
| JP4716769B2 (ja) * | 2005-03-29 | 2011-07-06 | キユーピー株式会社 | 血圧降下剤の製造方法 |
| JP4716770B2 (ja) * | 2005-03-29 | 2011-07-06 | キユーピー株式会社 | 免疫賦活・アレルギー改善剤の製造方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO134752C (en, 2012) * | 1965-06-01 | 1976-12-08 | Texim Entreprise Economique D | |
| SU618088A1 (ru) * | 1975-06-03 | 1978-08-05 | Киргизский Научно-Исследовательский Институт Акушерства И Педиатрии | Способ получени детского лечебного кисломолочного продукта |
| FR2343484A1 (fr) * | 1976-03-10 | 1977-10-07 | Anvar | Le 2- (2-acetamido-2-deoxy-3-o-d-glucopyranosyl) -d-propionyl-l-alanyl-d- (a-methylamide)-glutamique et medicaments le contenant |
| SU789096A1 (ru) * | 1978-03-23 | 1980-12-23 | Киргизский Научно-Исследовательский Институт Акушерства И Педиатрии | Способ получени кисломолочного продукта дл детского питани |
| JPS5553298A (en) * | 1978-10-17 | 1980-04-18 | Dainippon Pharmaceut Co Ltd | Water-soluble peptide glycan |
| FR2454302A1 (fr) * | 1979-04-18 | 1980-11-14 | Rhone Poulenc Ind | Nouvelle substance biologiquement active, sa preparation et les medicaments qui la contiennent |
| JPS58126797A (ja) * | 1982-01-22 | 1983-07-28 | Dainippon Pharmaceut Co Ltd | ジサツカライドトリペプチド及びジサツカライドテトラペプチドの製法 |
| FR2523154A1 (fr) * | 1982-03-09 | 1983-09-16 | Fabre Sa Pierre | Procede de preparation de proteoglycanes immunostimulants inducteurs d'interferon, proteoglycanes obtenus et medicaments les contenant |
| SU1465003A1 (ru) † | 1987-06-25 | 1989-03-15 | Всесоюзный научно-исследовательский и конструкторский институт молочной промышленности | Способ производства адаптированного кисломолочного продукта дл детского питани |
-
1989
- 1989-12-13 CH CH4484/89A patent/CH680192A5/fr not_active IP Right Cessation
-
1990
- 1990-11-14 DE DE69022005T patent/DE69022005T3/de not_active Expired - Lifetime
- 1990-11-14 DK DK90121752T patent/DK0432490T4/da not_active Application Discontinuation
- 1990-11-14 ES ES90121752T patent/ES2076280T5/es not_active Expired - Lifetime
- 1990-11-14 AT AT90121752T patent/ATE127023T1/de not_active IP Right Cessation
- 1990-11-14 EP EP90121752A patent/EP0432490B2/fr not_active Expired - Lifetime
- 1990-11-27 CA CA002030951A patent/CA2030951C/en not_active Expired - Lifetime
- 1990-11-27 AU AU67021/90A patent/AU643728B2/en not_active Expired
- 1990-11-27 US US07/619,119 patent/US5185321A/en not_active Expired - Lifetime
- 1990-11-30 NZ NZ236295A patent/NZ236295A/en unknown
- 1990-11-30 IE IE432390A patent/IE68244B1/en not_active IP Right Cessation
- 1990-11-30 ZA ZA909658A patent/ZA909658B/xx unknown
- 1990-12-03 NO NO19905228A patent/NO310498B1/no not_active IP Right Cessation
- 1990-12-11 MX MX023693A patent/MX172984B/es unknown
- 1990-12-12 PT PT96167A patent/PT96167B/pt not_active IP Right Cessation
- 1990-12-13 JP JP2402041A patent/JP2595133B2/ja not_active Expired - Lifetime
-
1995
- 1995-09-18 GR GR950402553T patent/GR3017428T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO905228D0 (no) | 1990-12-03 |
| NO905228L (no) | 1991-06-14 |
| EP0432490A3 (en) | 1991-08-21 |
| PT96167B (pt) | 2001-05-31 |
| PT96167A (pt) | 1991-09-30 |
| ES2076280T3 (es) | 1995-11-01 |
| CA2030951C (en) | 2002-01-15 |
| ZA909658B (en) | 1991-09-25 |
| EP0432490B2 (fr) | 2001-05-16 |
| EP0432490A2 (fr) | 1991-06-19 |
| AU643728B2 (en) | 1993-11-25 |
| MX172984B (es) | 1994-01-26 |
| DE69022005T2 (de) | 1996-02-15 |
| NZ236295A (en) | 1993-04-28 |
| ATE127023T1 (de) | 1995-09-15 |
| DE69022005D1 (de) | 1995-10-05 |
| JPH03255034A (ja) | 1991-11-13 |
| DK0432490T3 (da) | 1995-12-27 |
| CA2030951A1 (en) | 1991-06-14 |
| AU6702190A (en) | 1991-06-20 |
| GR3017428T3 (en) | 1995-12-31 |
| DE69022005T3 (de) | 2001-10-04 |
| NO310498B1 (no) | 2001-07-16 |
| IE904323A1 (en) | 1991-06-19 |
| US5185321A (en) | 1993-02-09 |
| EP0432490B1 (fr) | 1995-08-30 |
| JP2595133B2 (ja) | 1997-03-26 |
| ES2076280T5 (es) | 2001-09-01 |
| DK0432490T4 (da) | 2001-08-06 |
| IE68244B1 (en) | 1996-06-12 |
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