CH680188A5 - - Google Patents
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- Publication number
- CH680188A5 CH680188A5 CH2294/90A CH229490A CH680188A5 CH 680188 A5 CH680188 A5 CH 680188A5 CH 2294/90 A CH2294/90 A CH 2294/90A CH 229490 A CH229490 A CH 229490A CH 680188 A5 CH680188 A5 CH 680188A5
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation according
- active ingredient
- film
- nonoxynol
- weight
- Prior art date
Links
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 9
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 8
- 201000010099 disease Diseases 0.000 claims abstract description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract description 4
- 239000002270 dispersing agent Substances 0.000 claims abstract description 3
- 239000004094 surface-active agent Substances 0.000 claims abstract description 3
- 239000000080 wetting agent Substances 0.000 claims abstract description 3
- 239000004480 active ingredient Substances 0.000 claims description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 17
- 238000002360 preparation method Methods 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 229920000847 nonoxynol Polymers 0.000 claims description 9
- 235000011187 glycerol Nutrition 0.000 claims description 7
- FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 claims description 5
- KUXGUCNZFCVULO-UHFFFAOYSA-N 2-(4-nonylphenoxy)ethanol Chemical class CCCCCCCCCC1=CC=C(OCCO)C=C1 KUXGUCNZFCVULO-UHFFFAOYSA-N 0.000 claims description 4
- 229920004918 nonoxynol-9 Polymers 0.000 claims description 4
- 229940087419 nonoxynol-9 Drugs 0.000 claims description 4
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 claims description 3
- 208000035143 Bacterial infection Diseases 0.000 claims description 3
- 241000233866 Fungi Species 0.000 claims description 3
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 3
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 3
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 3
- 229960003913 econazole Drugs 0.000 claims description 3
- 229960000282 metronidazole Drugs 0.000 claims description 3
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims description 3
- SODWJACROGQSMM-UHFFFAOYSA-N 5,6,7,8-tetrahydronaphthalen-1-amine Chemical compound C1CCCC2=C1C=CC=C2N SODWJACROGQSMM-UHFFFAOYSA-N 0.000 claims description 2
- SBKRTALNRRAOJP-BWSIXKJUSA-N N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methylheptanamide (6S)-N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide sulfuric acid Polymers OS(O)(=O)=O.CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O.CC[C@H](C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O SBKRTALNRRAOJP-BWSIXKJUSA-N 0.000 claims description 2
- 229930193140 Neomycin Natural products 0.000 claims description 2
- 108010093965 Polymyxin B Proteins 0.000 claims description 2
- 108010040201 Polymyxins Proteins 0.000 claims description 2
- 241001502500 Trichomonadida Species 0.000 claims description 2
- 208000036142 Viral infection Diseases 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 229960003645 econazole nitrate Drugs 0.000 claims description 2
- 238000004049 embossing Methods 0.000 claims description 2
- PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 claims description 2
- 229960002829 neomycin b sulfate Drugs 0.000 claims description 2
- 229940073555 nonoxynol-10 Drugs 0.000 claims description 2
- 210000002826 placenta Anatomy 0.000 claims description 2
- 229960003548 polymyxin b sulfate Drugs 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 230000009385 viral infection Effects 0.000 claims description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- -1 neomycin B sulfate Natural products 0.000 claims 2
- 206010065764 Mucosal infection Diseases 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 229960004927 neomycin Drugs 0.000 claims 1
- 239000002304 perfume Substances 0.000 claims 1
- 239000004014 plasticizer Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 150000005846 sugar alcohols Polymers 0.000 claims 1
- 239000013543 active substance Substances 0.000 abstract description 3
- 208000013464 vaginal disease Diseases 0.000 abstract description 2
- OMOVVBIIQSXZSZ-UHFFFAOYSA-N [6-(4-acetyloxy-5,9a-dimethyl-2,7-dioxo-4,5a,6,9-tetrahydro-3h-pyrano[3,4-b]oxepin-5-yl)-5-formyloxy-3-(furan-3-yl)-3a-methyl-7-methylidene-1a,2,3,4,5,6-hexahydroindeno[1,7a-b]oxiren-4-yl] 2-hydroxy-3-methylpentanoate Chemical compound CC12C(OC(=O)C(O)C(C)CC)C(OC=O)C(C3(C)C(CC(=O)OC4(C)COC(=O)CC43)OC(C)=O)C(=C)C32OC3CC1C=1C=COC=1 OMOVVBIIQSXZSZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000007970 homogeneous dispersion Substances 0.000 abstract 1
- 238000005266 casting Methods 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 238000003756 stirring Methods 0.000 description 7
- 238000001035 drying Methods 0.000 description 5
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 4
- 239000003960 organic solvent Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 210000001215 vagina Anatomy 0.000 description 2
- 229910000669 Chrome steel Inorganic materials 0.000 description 1
- 241000224526 Trichomonas Species 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000004526 pharmaceutical effect Effects 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 229940041153 polymyxins Drugs 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000000003 vaginal tablet Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH2294/90A CH680188A5 (en:Method) | 1990-07-10 | 1990-07-10 | |
| AT91111400T ATE110264T1 (de) | 1990-07-10 | 1991-07-09 | Pharmazeutisches, vaginal zu applizierendes präparat. |
| PT98256A PT98256B (pt) | 1990-07-10 | 1991-07-09 | Processo para a obtencao de um preparado farmaceutico, para aplicacao vaginal, contendo um alcool polivinilico |
| EP91111400A EP0466092B1 (de) | 1990-07-10 | 1991-07-09 | Pharmazeutisches, vaginal zu applizierendes Präparat |
| IE239291A IE66119B1 (en) | 1990-07-10 | 1991-07-09 | Pharmaceutical vaginal applicable preparation |
| DE59102616T DE59102616D1 (de) | 1990-07-10 | 1991-07-09 | Pharmazeutisches, vaginal zu applizierendes Präparat. |
| US08/110,758 US5380529A (en) | 1990-07-10 | 1993-08-23 | Pharmaceutical, vaginal applicable preparation and a process for its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH2294/90A CH680188A5 (en:Method) | 1990-07-10 | 1990-07-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH680188A5 true CH680188A5 (en:Method) | 1992-07-15 |
Family
ID=4230413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH2294/90A CH680188A5 (en:Method) | 1990-07-10 | 1990-07-10 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0466092B1 (en:Method) |
| AT (1) | ATE110264T1 (en:Method) |
| CH (1) | CH680188A5 (en:Method) |
| DE (1) | DE59102616D1 (en:Method) |
| IE (1) | IE66119B1 (en:Method) |
| PT (1) | PT98256B (en:Method) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001341145A (ja) * | 1999-12-23 | 2001-12-11 | Johnson & Johnson Consumer Co Inc | 水溶性フィルムの製造方法 |
| US6432108B1 (en) | 2000-01-24 | 2002-08-13 | Depuy Orthopaedics, Inc. | Transverse connector |
| US7628799B2 (en) | 2005-08-23 | 2009-12-08 | Aesculap Ag & Co. Kg | Rod to rod connector |
| US7744632B2 (en) | 2006-12-20 | 2010-06-29 | Aesculap Implant Systems, Inc. | Rod to rod connector |
| HU3864U (en) | 2010-03-12 | 2010-12-28 | Gynopatch Kft | Impregnated plaster for female hygiene |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1196678A (en) * | 1967-04-24 | 1970-07-01 | Chemolimpex | Improvements in Contraceptive Devices |
-
1990
- 1990-07-10 CH CH2294/90A patent/CH680188A5/de not_active IP Right Cessation
-
1991
- 1991-07-09 PT PT98256A patent/PT98256B/pt not_active IP Right Cessation
- 1991-07-09 EP EP91111400A patent/EP0466092B1/de not_active Expired - Lifetime
- 1991-07-09 IE IE239291A patent/IE66119B1/en not_active IP Right Cessation
- 1991-07-09 AT AT91111400T patent/ATE110264T1/de not_active IP Right Cessation
- 1991-07-09 DE DE59102616T patent/DE59102616D1/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE110264T1 (de) | 1994-09-15 |
| DE59102616D1 (de) | 1994-09-29 |
| EP0466092A1 (de) | 1992-01-15 |
| EP0466092B1 (de) | 1994-08-24 |
| PT98256B (pt) | 1998-12-31 |
| PT98256A (pt) | 1992-04-30 |
| IE912392A1 (en) | 1992-01-15 |
| IE66119B1 (en) | 1995-12-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |