CH658455A5 - Peptidderivate, verfahren zu deren herstellung und diese enthaltende arzneimittel. - Google Patents
Peptidderivate, verfahren zu deren herstellung und diese enthaltende arzneimittel. Download PDFInfo
- Publication number
- CH658455A5 CH658455A5 CH1691/82A CH169182A CH658455A5 CH 658455 A5 CH658455 A5 CH 658455A5 CH 1691/82 A CH1691/82 A CH 1691/82A CH 169182 A CH169182 A CH 169182A CH 658455 A5 CH658455 A5 CH 658455A5
- Authority
- CH
- Switzerland
- Prior art keywords
- carboxylic acid
- tetrahydroisoquinoline
- alanyl
- carboethoxy
- mmol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24540781A | 1981-03-19 | 1981-03-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH658455A5 true CH658455A5 (de) | 1986-11-14 |
Family
ID=22926526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1691/82A CH658455A5 (de) | 1981-03-19 | 1982-03-18 | Peptidderivate, verfahren zu deren herstellung und diese enthaltende arzneimittel. |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS57165355A (es) |
| KR (1) | KR890001146B1 (es) |
| AU (1) | AU558451B2 (es) |
| BE (1) | BE892552A (es) |
| CH (1) | CH658455A5 (es) |
| DE (1) | DE3209708A1 (es) |
| DK (1) | DK120982A (es) |
| ES (3) | ES510498A0 (es) |
| FI (1) | FI820974L (es) |
| FR (1) | FR2502149A1 (es) |
| GB (1) | GB2095252B (es) |
| IE (1) | IE53076B1 (es) |
| IL (1) | IL65247A (es) |
| IN (1) | IN156096B (es) |
| IT (1) | IT1150697B (es) |
| NL (1) | NL8201066A (es) |
| NO (1) | NO820903L (es) |
| NZ (1) | NZ200047A (es) |
| PH (1) | PH18657A (es) |
| SE (1) | SE8201654L (es) |
| ZA (1) | ZA821833B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3242599A1 (de) * | 1982-11-18 | 1984-05-24 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel |
| US4410520A (en) * | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| US4555502A (en) * | 1982-09-30 | 1985-11-26 | Merck & Co., Inc. | Aminoacyl-containing dipeptide derivatives useful as antihypertensives |
| US4410807A (en) * | 1982-03-26 | 1983-10-18 | Kay Industries, Inc. | Regulating device for polyphase electrical circuits |
| US4473575A (en) * | 1982-07-19 | 1984-09-25 | Ciba-Geigy Corporation | 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids |
| US4520025A (en) * | 1982-07-21 | 1985-05-28 | William H. Rorer, Inc. | Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses |
| DE3302125A1 (de) * | 1983-01-22 | 1984-07-26 | Boehringer Ingelheim KG, 6507 Ingelheim | Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung |
| DK156484A (da) * | 1983-03-16 | 1984-09-17 | Usv Pharma Corp | Aminosyrederivater |
| DE3333454A1 (de) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern |
| DE3622297A1 (de) * | 1986-07-03 | 1988-01-07 | Basf Ag | Disazothiophenfarbstoffe |
| US5246943A (en) * | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
| ES2122941B1 (es) * | 1997-05-29 | 1999-07-01 | Esteve Quimica Sa | Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato. |
| SI1333026T1 (sl) | 2002-01-30 | 2007-10-31 | Servier Lab | Postopek priprave perindoprila visoke äśistoäśe in intermediatov uporabnih v sintezi |
| US7482361B2 (en) | 2002-12-16 | 2009-01-27 | Lupin Limited | Crystalline form for quinapril hydrochloride and process for preparing the same |
| DK1603558T3 (da) * | 2003-02-28 | 2008-09-01 | Servier S A Lab | Fremgangsmåde til fremstilling af perindopril og salte deraf |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2503155A2 (fr) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| EP0046953B1 (de) * | 1980-08-30 | 1989-12-06 | Hoechst Aktiengesellschaft | Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung |
| US4344949A (en) * | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
| GB2086390B (en) * | 1980-11-03 | 1984-06-06 | Ciba Geigy Ag | 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application |
-
1982
- 1982-03-08 IN IN265/CAL/82A patent/IN156096B/en unknown
- 1982-03-15 NL NL8201066A patent/NL8201066A/nl not_active Application Discontinuation
- 1982-03-15 PH PH26998A patent/PH18657A/en unknown
- 1982-03-15 IL IL65247A patent/IL65247A/xx unknown
- 1982-03-16 AU AU81584/82A patent/AU558451B2/en not_active Ceased
- 1982-03-16 SE SE8201654A patent/SE8201654L/xx not_active Application Discontinuation
- 1982-03-17 GB GB8207770A patent/GB2095252B/en not_active Expired
- 1982-03-17 DE DE19823209708 patent/DE3209708A1/de not_active Withdrawn
- 1982-03-17 ES ES510498A patent/ES510498A0/es active Granted
- 1982-03-18 DK DK120982A patent/DK120982A/da not_active Application Discontinuation
- 1982-03-18 CH CH1691/82A patent/CH658455A5/de not_active IP Right Cessation
- 1982-03-18 BE BE0/207610A patent/BE892552A/fr not_active IP Right Cessation
- 1982-03-18 IT IT20259/82A patent/IT1150697B/it active
- 1982-03-18 ZA ZA821833A patent/ZA821833B/xx unknown
- 1982-03-18 NZ NZ200047A patent/NZ200047A/en unknown
- 1982-03-18 KR KR8201157A patent/KR890001146B1/ko active
- 1982-03-18 NO NO820903A patent/NO820903L/no unknown
- 1982-03-18 JP JP57041801A patent/JPS57165355A/ja active Pending
- 1982-03-19 FI FI820974A patent/FI820974L/fi not_active Application Discontinuation
- 1982-03-19 FR FR8204738A patent/FR2502149A1/fr active Granted
- 1982-03-19 IE IE635/82A patent/IE53076B1/en unknown
-
1983
- 1983-03-16 ES ES521030A patent/ES521030A0/es active Granted
- 1983-03-16 ES ES521031A patent/ES521031A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| PH18657A (en) | 1985-08-29 |
| ES8404317A1 (es) | 1984-05-16 |
| NL8201066A (nl) | 1982-10-18 |
| KR890001146B1 (ko) | 1989-04-25 |
| IT8220259A0 (it) | 1982-03-18 |
| IE53076B1 (en) | 1988-06-08 |
| IE820635L (en) | 1982-09-19 |
| FI820974L (fi) | 1982-09-20 |
| DK120982A (da) | 1982-09-20 |
| IL65247A (en) | 1987-07-31 |
| NZ200047A (en) | 1985-07-12 |
| ES521030A0 (es) | 1984-05-16 |
| BE892552A (fr) | 1982-09-20 |
| IL65247A0 (en) | 1982-05-31 |
| GB2095252B (en) | 1985-04-17 |
| AU558451B2 (en) | 1987-01-29 |
| IN156096B (es) | 1985-05-11 |
| NO820903L (no) | 1982-09-20 |
| KR830009065A (ko) | 1983-12-17 |
| ES8501363A1 (es) | 1984-12-01 |
| FR2502149A1 (fr) | 1982-09-24 |
| FR2502149B1 (es) | 1985-01-18 |
| DE3209708A1 (de) | 1982-10-21 |
| IT1150697B (it) | 1986-12-17 |
| JPS57165355A (en) | 1982-10-12 |
| ES8307718A1 (es) | 1983-08-01 |
| ES510498A0 (es) | 1983-08-01 |
| AU8158482A (en) | 1982-09-23 |
| GB2095252A (en) | 1982-09-29 |
| ES521031A0 (es) | 1984-12-01 |
| SE8201654L (sv) | 1982-09-20 |
| ZA821833B (en) | 1983-01-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4128653A (en) | Reduction of blood pressure with carboxyalkylacyl-pipecolic acid derivatives | |
| KR890000662B1 (ko) | 1-카복시 알카노일 인돌린-2-카복실산 유도체의 제조방법 | |
| EP0119954B1 (de) | Gewisse 3-Amino-1-benzazepin-2-on-1-alkansäuren, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen, sowie ihre therapeutische Verwendung | |
| DE69310475T2 (de) | Benzokondensierte Lactame | |
| KR100504449B1 (ko) | 세포 유착 억제제 | |
| EP0236872B1 (de) | Hydroxylaminderivate, deren Herstellung und Verwendung für Heilmittel | |
| EP0100200B1 (en) | 2-substituted 4-amino-6,7-dimethoxyquinolines | |
| DE69416629T2 (de) | 2-Piperazinon-Verbindungen und deren Verwendung | |
| EP0119161B1 (de) | Gewisse Benzazocinon- und Benzazoninon-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen, sowie ihre therapeutische Verwendung | |
| EP0072352A1 (de) | Benzazepin-2-one, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese Verbindungen enthalten, sowie die Verbindungen zur therapeutischen Verwendung | |
| CH658455A5 (de) | Peptidderivate, verfahren zu deren herstellung und diese enthaltende arzneimittel. | |
| JPH09500109A (ja) | ファルネシル蛋白質トランスフェラーゼの阻害剤 | |
| DD201782A5 (de) | Verfahren zur herstellung von octahydro-1-(omega-mercaptoalkanoyl)-1h-indol 2-carbonsaeure-verbindungen | |
| CA2198726A1 (en) | Inhibitors of farnesyl-protein transferase | |
| DE69606632T2 (de) | Antithrombotische amidinotetrahydropyridylanin-derivate | |
| US4154937A (en) | Hydroxycarbamoylalkylacylpipecolic acid compounds | |
| DE69715886T2 (de) | Acylaminoalkenylen-amid-derivate als nk1 und nk2 antagonisten | |
| DE4443390A1 (de) | Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten | |
| EP0847994B1 (de) | Verfahren zur Herstellung gemischter Anhydride | |
| DE3787042T2 (de) | Tripeptid-Derivate. | |
| EP0230242A2 (de) | Substituierte 4-Amino-3-hydroxy-buttersäure-Derivate, Verfahren zu deren Herstellung, diese enthaltende Mittel und ihre Verwendung | |
| CZ322092A3 (en) | N-(alpha-substituted pyridinyl)carbonyl dipeptides, process of their preparation and pharmaceutical compositions based thereon | |
| EP0093805A1 (en) | Octahydro-2-(omega-mercaptoalkanoyl)3-oxo-1H-isoindole-1-carboxylic acids and esters | |
| EP0403828A1 (de) | Renininhibitorische Peptide, Verfahren zur ihrer Herstellung und ihre Verwendung in Arzneimitteln | |
| DE3507575A1 (de) | Antihypertensive cyclische spiro-verbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |