CH626917A5 - - Google Patents

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Publication number
CH626917A5
CH626917A5 CH1049376A CH1049376A CH626917A5 CH 626917 A5 CH626917 A5 CH 626917A5 CH 1049376 A CH1049376 A CH 1049376A CH 1049376 A CH1049376 A CH 1049376A CH 626917 A5 CH626917 A5 CH 626917A5
Authority
CH
Switzerland
Prior art keywords
heparin
enzyme
insolubilized
thrombin
buffer
Prior art date
Application number
CH1049376A
Other languages
German (de)
English (en)
Inventor
Kurt F Stocker
Original Assignee
Pentapharm Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pentapharm Ag filed Critical Pentapharm Ag
Priority to CH1049376A priority Critical patent/CH626917A5/de
Priority to US05/819,473 priority patent/US4137127A/en
Priority to IL52607A priority patent/IL52607A/xx
Priority to DE2734427A priority patent/DE2734427C3/de
Priority to NLAANVRAGE7708515,A priority patent/NL186018C/xx
Priority to AU27633/77A priority patent/AU507161B2/en
Priority to IT26662/77A priority patent/IT1083927B/it
Priority to ES461549A priority patent/ES461549A1/es
Priority to LU77957A priority patent/LU77957A1/xx
Priority to SU772510853A priority patent/SU946389A3/ru
Priority to NO772862A priority patent/NO147526C/no
Priority to SE7709241A priority patent/SE433619B/xx
Priority to FR7725075A priority patent/FR2362155A1/fr
Priority to DK364077A priority patent/DK147408C/da
Priority to CA284,759A priority patent/CA1078732A/en
Priority to AT590477A priority patent/AT361616B/de
Priority to BE180247A priority patent/BE857876A/xx
Priority to GB34491/77A priority patent/GB1591333A/en
Priority to JP9860577A priority patent/JPS5324095A/ja
Publication of CH626917A5 publication Critical patent/CH626917A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6418—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals from snakes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Drying Of Solid Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
CH1049376A 1976-08-17 1976-08-17 CH626917A5 (cs)

Priority Applications (19)

Application Number Priority Date Filing Date Title
CH1049376A CH626917A5 (cs) 1976-08-17 1976-08-17
US05/819,473 US4137127A (en) 1976-08-17 1977-07-27 Process for the preparation of thrombin-like enzymes from snake venoms
IL52607A IL52607A (en) 1976-08-17 1977-07-27 Process for the preparation of thrombin like enzymes from snake venoms
DE2734427A DE2734427C3 (de) 1976-08-17 1977-07-29 Verfahren zur Gewinnung von thrombinartigen Enzymen aus Schlangengiften
NLAANVRAGE7708515,A NL186018C (nl) 1976-08-17 1977-08-02 Werkwijze voor het winnen van thrombine-achtige enzymen uit slangegiffen, alsmede werkwijze ter bereiding van een farmaceutisch preparaat.
AU27633/77A AU507161B2 (en) 1976-08-17 1977-08-04 Purification of thrombin-like enzymes from snake venom
IT26662/77A IT1083927B (it) 1976-08-17 1977-08-11 Procedimento per l'estrazione di enzimi trombino-simili da veleni di serpenti
ES461549A ES461549A1 (es) 1976-08-17 1977-08-11 Procedimiento para la obtencion de encinas proteoliticos ti-po trombina.
LU77957A LU77957A1 (cs) 1976-08-17 1977-08-12
SU772510853A SU946389A3 (ru) 1976-08-17 1977-08-15 Способ получени тромбиноподобных ферментов
NO772862A NO147526C (no) 1976-08-17 1977-08-16 Fremgangsmaate ved fremstilling av trombinliknende enzymer fra slangegifter.
SE7709241A SE433619B (sv) 1976-08-17 1977-08-16 Forfarande for utvinning av trombinartade proteolytiska enzymer ur ormgifter
FR7725075A FR2362155A1 (fr) 1976-08-17 1977-08-16 Procede pour l'obtention d'enzymes semblables a la thrombine a partir de venins de serpents
DK364077A DK147408C (da) 1976-08-17 1977-08-16 Fremgangsmaade til udvinding af thrombinagtige enzymer fra slangegifte eller slangegiftfraktioner
CA284,759A CA1078732A (en) 1976-08-17 1977-08-16 Process for the preparation of thrombinlike enzymes from snake venoms
AT590477A AT361616B (de) 1976-08-17 1977-08-16 Verfahren zur gewinnung von thrombinartigen proteolytischen enzymen aus schlangengiften bzw. schlangengiftfraktionen
BE180247A BE857876A (fr) 1976-08-17 1977-08-17 Procede pour l'obtention d'enzymes semblables a la thrombine a partir de venins de serpents
GB34491/77A GB1591333A (en) 1976-08-17 1977-08-17 Process for the preparation of thrombin-like enzymes from snake venoms
JP9860577A JPS5324095A (en) 1976-08-17 1977-08-17 Production of thronbin like enzyme from snake venom

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1049376A CH626917A5 (cs) 1976-08-17 1976-08-17

Publications (1)

Publication Number Publication Date
CH626917A5 true CH626917A5 (cs) 1981-12-15

Family

ID=4363807

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1049376A CH626917A5 (cs) 1976-08-17 1976-08-17

Country Status (19)

Country Link
US (1) US4137127A (cs)
JP (1) JPS5324095A (cs)
AT (1) AT361616B (cs)
AU (1) AU507161B2 (cs)
BE (1) BE857876A (cs)
CA (1) CA1078732A (cs)
CH (1) CH626917A5 (cs)
DE (1) DE2734427C3 (cs)
DK (1) DK147408C (cs)
ES (1) ES461549A1 (cs)
FR (1) FR2362155A1 (cs)
GB (1) GB1591333A (cs)
IL (1) IL52607A (cs)
IT (1) IT1083927B (cs)
LU (1) LU77957A1 (cs)
NL (1) NL186018C (cs)
NO (1) NO147526C (cs)
SE (1) SE433619B (cs)
SU (1) SU946389A3 (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3512910A1 (de) * 1985-04-11 1986-10-16 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung von plasminogenaktivatoren
US4849403A (en) * 1985-05-29 1989-07-18 Pentapharm Ag Protein C activator, methods of preparation and use thereof
US5100668A (en) * 1988-06-14 1992-03-31 Massachusetts Institute Of Technology Controlled release systems containing heparin and growth factors
US5196193A (en) * 1989-10-31 1993-03-23 Ophidian Pharmaceuticals, Inc. Antivenoms and methods for making antivenoms
ES2131504T3 (es) * 1990-02-20 1999-08-01 Baxter Int Trombina humana purificada viricamente segura.
EP0585504A1 (en) * 1992-09-04 1994-03-09 Pentapharm A.G. Phospholipid dependant prothrombin activator and its use in lupus anticoagulant testing
DE19607210A1 (de) 1996-02-26 1997-08-28 Knoll Ag Verfahren zur Reinigung von thrombinähnlichen Proteasen aus Schlangengiften
JP2001508447A (ja) * 1997-01-08 2001-06-26 ブリストル−マイヤーズ スクイブ カンパニー 温度制御手段を備えた遠心分離装置
US6132598A (en) * 1997-01-08 2000-10-17 Bristol-Myers Squibb Company Centrifuge apparatus with temperature control means
WO2001048486A1 (fr) * 1999-12-24 2001-07-05 International Reagents Corporation Moyen de stabilisation de compositions et reactifs
EP1774976B1 (en) * 2004-06-24 2012-06-13 Tobishi Pharmaceutical Co., Ltd. Malignant tumor local infiltration inhibitor containing batroxobin
US20100034803A1 (en) * 2005-09-30 2010-02-11 Tobishi Pharmaceutical Co., Ltd. Activating agent of stem cells and/or progenitor cells
RU2469740C2 (ru) * 2007-12-14 2012-12-20 Тобиси Фармасьютикал Ко., Лтд. Средство для снижения побочного эффекта противоракового лекарственного средства
TWI482629B (zh) * 2008-07-01 2015-05-01 Tobishi Pharmaceutical Co 下泌尿道疾病治療劑及下泌尿道症狀改善劑
WO2019068940A1 (en) * 2018-01-25 2019-04-11 Dsm Ip Assets B.V. FIBRINOGEN TEST

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH586233A5 (cs) * 1971-01-18 1977-03-31 Pentapharm Ag
SE420321B (sv) * 1973-09-03 1981-09-28 Fargal Pharmasint Lab Biochim Kromatografisk extraktion och isolering av enzymatisk komponent fran ormgift

Also Published As

Publication number Publication date
IL52607A0 (en) 1977-10-31
JPS5324095A (en) 1978-03-06
NL186018B (nl) 1990-04-02
CA1078732A (en) 1980-06-03
SE7709241L (sv) 1978-02-18
IT1083927B (it) 1985-05-25
FR2362155B1 (cs) 1980-06-06
DK364077A (da) 1978-02-18
DK147408B (da) 1984-07-23
ES461549A1 (es) 1978-06-01
AU507161B2 (en) 1980-02-07
NL7708515A (nl) 1978-02-21
NO147526C (no) 1983-04-27
AU2763377A (en) 1979-02-08
FR2362155A1 (fr) 1978-03-17
NL186018C (nl) 1990-09-03
SU946389A3 (ru) 1982-07-23
SE433619B (sv) 1984-06-04
DK147408C (da) 1985-02-04
LU77957A1 (cs) 1977-12-14
GB1591333A (en) 1981-06-17
JPS5710718B2 (cs) 1982-02-27
BE857876A (fr) 1977-12-16
US4137127A (en) 1979-01-30
NO772862L (no) 1978-02-20
DE2734427A1 (de) 1978-02-23
DE2734427C3 (de) 1980-04-17
ATA590477A (de) 1980-08-15
AT361616B (de) 1981-03-25
NO147526B (no) 1983-01-17
IL52607A (en) 1980-02-29
DE2734427B2 (de) 1979-08-09

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Date Code Title Description
PL Patent ceased