CH624962A5 - Process for the preparation of novel amide derivatives of dimeric vinblastin alkaloids - Google Patents

Process for the preparation of novel amide derivatives of dimeric vinblastin alkaloids Download PDF

Info

Publication number
CH624962A5
CH624962A5 CH1684075A CH1684075A CH624962A5 CH 624962 A5 CH624962 A5 CH 624962A5 CH 1684075 A CH1684075 A CH 1684075A CH 1684075 A CH1684075 A CH 1684075A CH 624962 A5 CH624962 A5 CH 624962A5
Authority
CH
Switzerland
Prior art keywords
hydrogen
alkyl
formula
compounds
hydroxy
Prior art date
Application number
CH1684075A
Other languages
German (de)
English (en)
Inventor
George Joseph Cullinan
Koert Gerzon
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CH624962A5 publication Critical patent/CH624962A5/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CH1684075A 1975-01-09 1975-12-29 Process for the preparation of novel amide derivatives of dimeric vinblastin alkaloids CH624962A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53968175A 1975-01-09 1975-01-09

Publications (1)

Publication Number Publication Date
CH624962A5 true CH624962A5 (en) 1981-08-31

Family

ID=24152219

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1684075A CH624962A5 (en) 1975-01-09 1975-12-29 Process for the preparation of novel amide derivatives of dimeric vinblastin alkaloids

Country Status (13)

Country Link
JP (1) JPS5195100A (el)
BE (1) BE837390A (el)
CA (1) CA1067073A (el)
CH (1) CH624962A5 (el)
CS (1) CS199615B2 (el)
DE (1) DE2558027A1 (el)
FR (1) FR2297043A1 (el)
GB (1) GB1538921A (el)
HU (1) HU176226B (el)
IE (1) IE42385B1 (el)
IL (1) IL48685A (el)
NL (1) NL7515253A (el)
PH (1) PH17563A (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR69783B (el) * 1976-09-08 1982-07-07 Lilly Co Eli
USRE30561E (en) 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
GR68940B (el) * 1977-01-19 1982-03-29 Lilly Co Eli
US4191688A (en) 1977-08-08 1980-03-04 Eli Lilly And Company Amides of leurosine, leuroformine, desacetylleurosine and desacetylleuroformine
US4195022A (en) 1978-03-27 1980-03-25 Eli Lilly And Company 4-Desacetoxy-4α-hydroxyvinblastine and related compounds
US4166810A (en) * 1978-04-20 1979-09-04 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide
US4199504A (en) * 1978-05-15 1980-04-22 Eli Lilly And Company Bridged cathranthus alkaloid dimers
AR225153A1 (es) * 1978-10-10 1982-02-26 Lilly Co Eli Un procedimiento para la preparacion de sulfato de vindesina
US4357334A (en) 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
LU83822A1 (fr) * 1981-12-08 1983-09-01 Omnichem Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina

Also Published As

Publication number Publication date
IE42385B1 (en) 1980-07-30
IL48685A (en) 1980-03-31
CS199615B2 (en) 1980-07-31
GB1538921A (en) 1979-01-24
FR2297043B1 (el) 1978-08-11
NL7515253A (nl) 1976-07-13
CA1067073A (en) 1979-11-27
BE837390A (fr) 1976-07-08
FR2297043A1 (fr) 1976-08-06
JPS5195100A (el) 1976-08-20
IE42385L (en) 1976-07-09
HU176226B (en) 1981-01-28
PH17563A (en) 1984-10-01
IL48685A0 (en) 1976-02-29
DE2558027A1 (de) 1976-07-15

Similar Documents

Publication Publication Date Title
DE2415980C2 (el)
DE2558124C2 (el)
DE3122479A1 (de) N-(vinblastin-23-oyl)-aminosaeurederivate
DD143075A5 (de) Verfahren zur herstellung von 4-desacetyl-vincaleucoblastin-c tief 3-carbonsaeurehydraziden
CH625530A5 (el)
CH617196A5 (el)
CH624962A5 (en) Process for the preparation of novel amide derivatives of dimeric vinblastin alkaloids
DD153372A5 (de) Verfahren zur herstellung von neuen ergolinderivaten
DE1811518C3 (de) Daunonibicinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE2753791C2 (el)
AT390958B (de) Verfahren zur herstellung neuer bisindolalkaloidderivate
DE2335750C3 (de) D-6-Methylergolin-derivate, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
DE2739443C2 (el)
DE2632118B2 (de) Apovincaminolester und Verfahren zu deren Herstellung und Arzneimittel
DE1695298C3 (de) S-Acetamido-e-methyl-e-n-propyl-striazolo eckige Klammer auf 4,3-a eckige Klammer zu pyrazin und Verfahren zu seiner Herstellung und Arzneimittel
DE2618223C2 (el)
DE2813286A1 (de) In 3'-stellung oxygenierte derivate von 4'-desoxy-vincaleukoblastin a und b sowie verwandte 1-formylverbindungen
AT345996B (de) Verfahren zur herstellung neuer amidderivate von vinblastin, leurosidin und leurocristin und ihrer saeureadditionssalze
DD147543A5 (de) Verfahren zur herstellung von dimeren vincaalkaloiden
EP0046565B1 (de) Neues Sparteinderivat, Verfahren zu seiner Herstellung, das Derivat enthaltende Arzneimittel und Verfahren zur Herstellung der Arzneimittel
CH618983A5 (el)
AT377764B (de) Verfahren zur herstellung von neuen 4-desacetyl-vincaleucoblastin-c3carbons|urehydraziden
AT377765B (de) Verfahren zur herstellung von neuen 4-desacetyl-vincaleucoblastin-c3carbons|urehydraziden
DE2221939B2 (de) 2-(3-Pyridazinyl)-3-(4-methylpiperazino-carbonyloxy)-1-isoindolinonderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
AT257836B (de) Verfahren zur Herstellung neuer N-Polyalkylderivate von Antibiotica

Legal Events

Date Code Title Description
PL Patent ceased