CH624113A5 - - Google Patents

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Publication number
CH624113A5
CH624113A5 CH817179A CH817179A CH624113A5 CH 624113 A5 CH624113 A5 CH 624113A5 CH 817179 A CH817179 A CH 817179A CH 817179 A CH817179 A CH 817179A CH 624113 A5 CH624113 A5 CH 624113A5
Authority
CH
Switzerland
Prior art keywords
acid
alkyl
formula
hpi
oxo
Prior art date
Application number
CH817179A
Other languages
German (de)
English (en)
Inventor
Juergen Dr Seubert
Rolf Dr Pohlke
Herbert Dr Thomas
Peter Dr Andrews
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of CH624113A5 publication Critical patent/CH624113A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CH817179A 1974-08-28 1979-09-10 CH624113A5 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2441261A DE2441261A1 (de) 1974-08-28 1974-08-28 Ringsubstituierte pyrazino-isochinolin-derivat und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
CH624113A5 true CH624113A5 (zh) 1981-07-15

Family

ID=5924323

Family Applications (3)

Application Number Title Priority Date Filing Date
CH1110675A CH617934A5 (zh) 1974-08-28 1975-08-27
CH817079A CH623584A5 (zh) 1974-08-28 1979-09-10
CH817179A CH624113A5 (zh) 1974-08-28 1979-09-10

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CH1110675A CH617934A5 (zh) 1974-08-28 1975-08-27
CH817079A CH623584A5 (zh) 1974-08-28 1979-09-10

Country Status (22)

Country Link
US (1) US4051243A (zh)
JP (1) JPS5168595A (zh)
AT (1) AT350055B (zh)
BE (1) BE832735A (zh)
CH (3) CH617934A5 (zh)
DD (1) DD121789A5 (zh)
DE (1) DE2441261A1 (zh)
DK (1) DK386175A (zh)
EG (1) EG12384A (zh)
ES (1) ES440509A1 (zh)
FI (1) FI752411A (zh)
FR (1) FR2282891A1 (zh)
GB (1) GB1479235A (zh)
IE (1) IE42218B1 (zh)
IL (1) IL47975A (zh)
LU (1) LU73263A1 (zh)
NL (1) NL7510173A (zh)
NO (1) NO752939L (zh)
OA (1) OA05094A (zh)
PH (1) PH12677A (zh)
SE (1) SE7509473L (zh)
ZA (1) ZA755480B (zh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141978A (en) * 1973-12-17 1979-02-27 Merck Patent Gesellschaft Mit Beschrankter Haftung 2-Acyl-4-oxo-pyrazino-isoquinoline derivatives and process for the preparation thereof
US4196291A (en) * 1973-12-17 1980-04-01 Merck Patent Gesellschaft Mit Beschraenkter Haftung 2-Acyl-4-oxo-pyrazino-isoquinoline derivatives and process for the preparation thereof
US4120961A (en) * 1974-08-28 1978-10-17 E. Merck Ring substituted pyrazino-isoquinoline derivatives and their preparation
FR2520740A1 (fr) * 1982-01-29 1983-08-05 Sanofi Sa Procede pour la preparation d'acyl-2-hexahydro-1,3,4,6,7,11b-2h-pyrazino (2,1-a) isoquinoleinones-4 et intermediaires
US4517187A (en) * 1982-10-18 1985-05-14 Pennwalt Corporation 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
DE3472678D1 (de) * 1983-07-18 1988-08-18 Beecham Group Plc Benzazepine and benzoxazepine derivatives
US4772705A (en) * 1985-07-25 1988-09-20 Pennwalt Corporation Processes for the preparation of trans 1,3,4,6,7,11b-hexahydro-7-aryl-2H-pyrazinol[2,1-a]isoquinolines
US20040131560A1 (en) * 2002-10-04 2004-07-08 The Procter & Gamble Company Oral compositions and use thereof
UA95093C2 (uk) 2005-12-07 2011-07-11 Нікомед Фарма Ас Спосіб одержання кальцієвмісної сполуки
EP2170814B1 (en) * 2007-06-12 2016-08-17 Achaogen, Inc. Antibacterial agents
CN101691367B (zh) * 2009-08-31 2013-07-24 中国人民解放军第二军医大学 具有抗真菌活性的哌嗪并[2,1-a]异喹啉类化合物或其盐类
US20220227765A1 (en) * 2019-08-28 2022-07-21 Ferro Therapeutics, Inc. Pyrido-indole analogues as gpx4 inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2362539C2 (de) * 1973-12-17 1986-05-07 Merck Patent Gmbh, 6100 Darmstadt 2-Acyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isochinoline, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
CH617934A5 (zh) 1980-06-30
EG12384A (en) 1980-03-31
ES440509A1 (es) 1977-06-01
IE42218L (en) 1976-02-28
JPS5168595A (en) 1976-06-14
AT350055B (de) 1979-05-10
DK386175A (da) 1976-02-29
FR2282891A1 (fr) 1976-03-26
BE832735A (nl) 1976-02-25
LU73263A1 (zh) 1977-04-15
ZA755480B (en) 1976-07-28
OA05094A (fr) 1981-01-31
NO752939L (zh) 1976-03-02
FR2282891B1 (zh) 1980-03-28
SE7509473L (sv) 1976-03-01
IL47975A0 (en) 1975-11-25
FI752411A (zh) 1976-02-29
IL47975A (en) 1980-05-30
US4051243A (en) 1977-09-27
ATA663375A (de) 1978-10-15
NL7510173A (nl) 1976-03-02
AU8410675A (en) 1977-02-24
CH623584A5 (zh) 1981-06-15
GB1479235A (en) 1977-07-06
DE2441261A1 (de) 1976-03-18
IE42218B1 (en) 1980-07-02
DD121789A5 (zh) 1976-08-20
PH12677A (en) 1979-07-11

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PL Patent ceased