GB1463520A
(en)
*
|
1974-09-06 |
1977-02-02 |
Pfizer Ltd |
Process for the production of imidazolines
|
JPS5373571A
(en)
*
|
1976-12-10 |
1978-06-30 |
Otsuka Pharmaceut Co Ltd |
Carbostyril derivatives
|
US4188393A
(en)
|
1977-04-22 |
1980-02-12 |
Sandoz Ltd. |
Treating spastic conditions or relaxing muscles
|
JPS542338A
(en)
|
1977-04-22 |
1979-01-09 |
Sandoz Ag |
Pharmaceutical composition
|
FR2449087A2
(fr)
*
|
1979-02-16 |
1980-09-12 |
Rhone Poulenc Ind |
Nouveaux derives de l'isoquinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent
|
US4486432A
(en)
*
|
1982-09-30 |
1984-12-04 |
Eli Lilly And Company |
Quinoxalinedione leukotriene release inhibitors
|
FR2541680B1
(fr)
*
|
1983-02-24 |
1985-06-14 |
Rhone Poulenc Sante |
Nouveaux derives de l'amino-5 dithiole-1,2 one-3, leur preparation et les compositions medicinales qui les contiennent
|
JPS6118950U
(ja)
*
|
1984-07-10 |
1986-02-03 |
財団法人鉄道総合技術研究所 |
トロリ線の給油装置
|
GB8827820D0
(en)
*
|
1988-11-29 |
1988-12-29 |
Janssen Pharmaceutica Nv |
(1h-azol-1-ylmethyl)substituted quinoline derivatives
|
US5180721A
(en)
*
|
1989-05-22 |
1993-01-19 |
Allergan, Inc. |
Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
|
US5281591A
(en)
*
|
1989-05-22 |
1994-01-25 |
Allergan, Inc. |
Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
|
US5077292A
(en)
*
|
1989-10-12 |
1991-12-31 |
Allergan, Inc. |
(2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same
|
US5204347A
(en)
*
|
1989-10-12 |
1993-04-20 |
Allergan, Inc. |
Methods for using (2-imidazolin-2-ylamino) tetrahydroquinoxalines
|
US5112822A
(en)
*
|
1989-10-12 |
1992-05-12 |
Allergan, Inc. |
(2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same
|
US5326763A
(en)
*
|
1989-10-12 |
1994-07-05 |
Allergan, Inc. |
Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
|
US5231096A
(en)
*
|
1989-10-12 |
1993-07-27 |
Allergan, Inc. |
Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
|
US5198442A
(en)
*
|
1989-10-12 |
1993-03-30 |
Allergan, Inc. |
(2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same
|
US5021416A
(en)
*
|
1989-10-31 |
1991-06-04 |
Allergan, Inc. |
Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure
|
US5215991A
(en)
*
|
1990-01-26 |
1993-06-01 |
Allergan, Inc. |
Combination of selective alpha-adrenergic agonists and Na+ /H+ ex
|
US5237072A
(en)
*
|
1990-02-06 |
1993-08-17 |
Allergan, Inc. |
Method for producing amino-2-imidazoline derivatives
|
US5130441A
(en)
*
|
1990-02-06 |
1992-07-14 |
Allergan, Inc. |
Method for producing amino-2-imidazoline derivatives
|
US5252595A
(en)
*
|
1990-02-28 |
1993-10-12 |
Allergan, Inc. |
Method for reducing or maintaining intraocular pressure in the mammalian eye by administering pharmaceutical compositions containing 2-(2-alkylphenylamino)-oxazolines, 2-(2-alkylphenylamino)-thiazolines and 2-(2-alkylphenylamino)-imidazolines
|
US5091528A
(en)
*
|
1990-09-12 |
1992-02-25 |
Allergan, Inc. |
6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
|
US6323204B1
(en)
*
|
1993-10-13 |
2001-11-27 |
Allergan |
Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
|
AU688380B2
(en)
*
|
1993-10-13 |
1998-03-12 |
Allergan, Inc. |
Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
|
US5580892A
(en)
*
|
1993-10-22 |
1996-12-03 |
Allergan |
Method for using 2-(2-alkylphenylamino)-oxazolines as adrenergic agents
|
SG44628A1
(en)
*
|
1993-12-17 |
1997-12-19 |
Procter & Gamble |
6-(2-imidazolinylamino) Quinoxaline compounds useful as alpha-2 adrenoceptor agonists
|
PL180392B1
(pl)
*
|
1993-12-17 |
2001-01-31 |
Procter & Gamble |
Zwiazki 6-(2-imidazolinyloamino)chinolinoweprzydatne jako agonisci a-2-adrenoceptorów i kompozycje farmaceutyczne je zawierajace PL PL PL PL PL PL PL PL
|
US5478858A
(en)
*
|
1993-12-17 |
1995-12-26 |
The Procter & Gamble Company |
5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
|
US5576437A
(en)
*
|
1993-12-17 |
1996-11-19 |
The Procter & Gamble Company |
7-(2-imidazolnylamino) quinoline compounds useful as alpha-2 adrenoceptor agonists
|
US5578607A
(en)
*
|
1993-12-17 |
1996-11-26 |
The Procter & Gamble Company |
6-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists
|
AU677513B2
(en)
*
|
1994-02-08 |
1997-04-24 |
Alcon Laboratories, Inc. |
Novel process for preparation of clonidine derivatives
|
AU704972B2
(en)
*
|
1994-08-04 |
1999-05-13 |
H. Lundbeck A/S |
Novel benzimidazole derivatives
|
US6294563B1
(en)
|
1994-10-27 |
2001-09-25 |
Allergan Sales, Inc. |
Combinations of prostaglandins and brimonidine or derivatives thereof
|
US6194415B1
(en)
|
1995-06-28 |
2001-02-27 |
Allergan Sales, Inc. |
Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury
|
US5916900A
(en)
|
1995-06-29 |
1999-06-29 |
The Procter & Gamble Company |
7-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists
|
CN1104422C
(zh)
|
1996-11-25 |
2003-04-02 |
普罗克特和甘保尔公司 |
用作α-2肾上腺素能受体兴奋剂的胍基杂环化合物
|
HUP0002966A3
(en)
*
|
1996-11-25 |
2001-10-29 |
Procter & Gamble |
2-imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists
|
US6306877B1
(en)
|
1999-08-09 |
2001-10-23 |
The Procter & Gamble Co. |
Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
|
SK68399A3
(en)
*
|
1996-11-25 |
2000-07-11 |
Procter & Gamble |
2-imidazolinylaminoindole compound, pharmaceutical composition containing the same and use thereof
|
AU5433898A
(en)
*
|
1996-11-25 |
1998-06-22 |
Procter & Gamble Company, The |
2-imidazolinylaminobenzothiazole compounds useful as alpha-2 adrenoceptor agonists
|
US6172095B1
(en)
|
1996-11-25 |
2001-01-09 |
The Procter & Gamble Company |
Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
|
US6495583B1
(en)
|
1997-03-25 |
2002-12-17 |
Synaptic Pharmaceutical Corporation |
Benzimidazole derivatives
|
DE69825075T2
(de)
|
1997-11-24 |
2005-08-25 |
The Procter & Gamble Company, Cincinnati |
5-(2-imidazolinylamino)-benzimidazol derivate, deren herstellung und deren verwendung als .alpha.-adrenoceptor agonisten mit verbesserter metabolischer stabilität
|
US6242442B1
(en)
|
1998-12-17 |
2001-06-05 |
Alcon Laboratories, Inc. |
Brinzolamide and brimonidine for treating ocular conditions
|
US20050026924A1
(en)
*
|
2000-07-14 |
2005-02-03 |
Allergan, Inc. |
Compositions containing alpha-2-adrenergic agonist components
|
RU2311928C2
(ru)
|
2000-07-14 |
2007-12-10 |
Аллерган Инк. |
Композиции, содержащие альфа-2-адренергические агонисты
|
US20040214829A1
(en)
*
|
2000-07-14 |
2004-10-28 |
Allergan, Inc. |
Compositions containing alpha-2-adrenergic agonist components
|
PL361027A1
(en)
*
|
2000-07-14 |
2004-09-20 |
Allergan,Inc. |
Compositions containing therapeutically active components having enhanced solubility
|
US8858961B2
(en)
|
2000-07-14 |
2014-10-14 |
Allergan, Inc. |
Compositions containing alpha-2-adrenergic agonist components
|
DE10161767A1
(de)
*
|
2001-12-15 |
2003-06-26 |
Merck Patent Gmbh |
2-Guanidino-4-heterocyclyl-chinazoline
|
US7030149B2
(en)
|
2002-04-19 |
2006-04-18 |
Allergan, Inc. |
Combination of brimonidine timolol for topical ophthalmic use
|
US7642258B2
(en)
*
|
2002-04-19 |
2010-01-05 |
Allergan, Inc. |
Combination of brimonidine and timolol for topical ophthalmic use
|
RU2330649C2
(ru)
*
|
2002-10-08 |
2008-08-10 |
Аллерган, Инк. |
Агонисты альфа-2в или 2в/2с адренорецепторов для лечения нейродегенеративных заболеваний
|
RU2332218C2
(ru)
*
|
2002-10-08 |
2008-08-27 |
Аллерган, Инк. |
Применение (2-имидазолин-2-иламино) хиноксалинов для лечения деменции и болезни паркинсона
|
US20040191332A1
(en)
*
|
2003-03-27 |
2004-09-30 |
Allergan, Inc. |
Preserved ophthalmic compositions
|
US8410102B2
(en)
|
2003-05-27 |
2013-04-02 |
Galderma Laboratories Inc. |
Methods and compositions for treating or preventing erythema
|
US7439241B2
(en)
|
2003-05-27 |
2008-10-21 |
Galderma Laboratories, Inc. |
Compounds, formulations, and methods for treating or preventing rosacea
|
AU2004263149B2
(en)
|
2003-08-07 |
2010-08-19 |
Allergan, Inc. |
Compositions for delivery of therapeutics into the eyes and methods for making and using same
|
US7501427B2
(en)
|
2003-08-14 |
2009-03-10 |
Array Biopharma, Inc. |
Quinazoline analogs as receptor tyrosine kinase inhibitors
|
CN103664802B
(zh)
*
|
2003-08-14 |
2015-08-05 |
阿雷生物药品公司 |
作为受体酪氨酸激酶抑制剂的喹唑啉类似物
|
US20070042951A1
(en)
*
|
2003-10-08 |
2007-02-22 |
Allergan, Inc. |
Pharmaceutical compositions comprising alpha-2-adrenergics and trefoil factor family peptides
|
PT1761266E
(pt)
|
2004-05-25 |
2013-06-04 |
Galderma Pharma Sa |
Compostos, formulações, e métodos para tratamento ou prevenção de distúrbios inflamatórios da pele
|
US7534795B2
(en)
*
|
2005-10-25 |
2009-05-19 |
Allergan, Inc. |
Compounds and their use related to compositions for treating disease
|
TWI435729B
(zh)
|
2005-11-09 |
2014-05-01 |
Combinatorx Inc |
治療病症之方法,組合物及套組
|
EP1971601B1
(en)
|
2005-11-15 |
2009-10-21 |
Array Biopharma Inc. |
N4-phenyl-quinazoline-4 -amine derivatives and related compounds as erbb type i receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases
|
WO2008074068A1
(en)
*
|
2006-12-20 |
2008-06-26 |
Prana Biotechnology Limited |
Substituted quinoline derivatives as antiamyloidogeneic agents
|
WO2008144399A1
(en)
*
|
2007-05-18 |
2008-11-27 |
Bausch & Lomb Incorporated |
COMPLEXES COMPRISING α2-ADRENERGIC RECEPTOR AGONISTS AND COMPOSITIONS
|
US9192571B2
(en)
*
|
2008-03-03 |
2015-11-24 |
Allergan, Inc. |
Ketorolac tromethamine compositions for treating or preventing ocular pain
|
US7842714B2
(en)
*
|
2008-03-03 |
2010-11-30 |
Allergan, Inc. |
Ketorolac tromethamine compositions for treating ocular pain
|
CA2777223C
(en)
|
2009-10-06 |
2017-10-24 |
Allergan, Inc. |
2h-pyrrol-5-amine derivatives as alpha adrenergic receptor modulators
|
EP2329849B1
(en)
|
2009-11-18 |
2015-04-29 |
Galderma Research & Development |
Combination of alpha-2 adrenergic receptor agonist and non-steroidal anti-inflammatory agent for treating or preventing an inflammatory skin disorder
|
US8394800B2
(en)
|
2009-11-19 |
2013-03-12 |
Galderma Laboratories, L.P. |
Method for treating psoriasis
|
US9522153B2
(en)
|
2009-12-22 |
2016-12-20 |
Allergan, Inc. |
Compositions and methods for lowering intraocular pressure
|
CA2792649A1
(en)
|
2010-03-26 |
2011-09-29 |
Michael Graeber |
Improved methods and compositions for safe and effective treatment of telangiectasia
|
PT2552449T
(pt)
|
2010-03-26 |
2017-06-12 |
Galderma Res & Dev |
Composições que compreendem brimonidina para o tratamento de eritema
|
CA2796045A1
(en)
|
2010-04-07 |
2011-10-13 |
Allergan, Inc. |
Combinations of preservatives for ophthalmic compositions
|
CA2796041A1
(en)
|
2010-04-07 |
2011-10-13 |
Allergan, Inc. |
Combinations of preservative compositions for ophthalmic formulations
|
EP2598119B1
(en)
|
2010-07-29 |
2018-09-19 |
Allergan, Inc. |
Preservative free brimonidine and timolol solutions
|
US8053427B1
(en)
|
2010-10-21 |
2011-11-08 |
Galderma R&D SNC |
Brimonidine gel composition
|
US20130261126A1
(en)
|
2010-10-21 |
2013-10-03 |
Galderma S.A. |
Brimonidiine gel compositions and methods of use
|
BR112014001938A2
(pt)
*
|
2011-07-25 |
2017-02-21 |
Allergan Inc |
derivados de n-(imidazolidin-2-ilideno) quinolina como moduladores dos receptores alfa 2 adrenérgicos
|
GR1009419B
(el)
|
2017-11-07 |
2018-12-14 |
Φαρματεν Αβεε |
Οφθαλμικο φαρμακευτικο σκευασμα που περιεχει εναν συνδυασμο βρινζολαμιδης και βριμονιδινης και μεθοδος για την παρασκευη αυτου
|