CH449643A - Verfahren zur Herstellung von neuen substituierten 6,7-Benzomorphanen - Google Patents
Verfahren zur Herstellung von neuen substituierten 6,7-BenzomorphanenInfo
- Publication number
- CH449643A CH449643A CH1619167A CH1619167A CH449643A CH 449643 A CH449643 A CH 449643A CH 1619167 A CH1619167 A CH 1619167A CH 1619167 A CH1619167 A CH 1619167A CH 449643 A CH449643 A CH 449643A
- Authority
- CH
- Switzerland
- Prior art keywords
- benzomorphans
- preparation
- new substituted
- substituted
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Discharge Lamp (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33229663A | 1963-12-20 | 1963-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH449643A true CH449643A (de) | 1968-01-15 |
Family
ID=23297612
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1538464A CH446371A (de) | 1963-12-20 | 1964-11-30 | Verfahren zur Herstellung von neuen substituierten 6,7-Benzomorphanen |
| CH1538364A CH448118A (de) | 1963-12-20 | 1964-11-30 | Verfahren zur Herstellung von neuen substituierten 6,7-Benzomorphanen |
| CH1618967A CH449641A (de) | 1963-12-20 | 1964-11-30 | Verfahren zur Herstellung von neuen substituierten 6,7-Benzomorphanen |
| CH1618767A CH449639A (de) | 1963-12-20 | 1964-11-30 | Verfahren zur Herstellung von neuen substituierten 6,7-Benzomorphanen |
| CH1618867A CH449640A (de) | 1963-12-20 | 1964-11-30 | Verfahren zur Herstellung von neuen substituierten 6,7-Benzomorphanen |
| CH1619067A CH449642A (de) | 1963-12-20 | 1964-11-30 | Verfahren zur Herstellung von neuen substituierten 6,7-Benzomorphanen |
| CH1619167A CH449643A (de) | 1963-12-20 | 1964-11-30 | Verfahren zur Herstellung von neuen substituierten 6,7-Benzomorphanen |
Family Applications Before (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1538464A CH446371A (de) | 1963-12-20 | 1964-11-30 | Verfahren zur Herstellung von neuen substituierten 6,7-Benzomorphanen |
| CH1538364A CH448118A (de) | 1963-12-20 | 1964-11-30 | Verfahren zur Herstellung von neuen substituierten 6,7-Benzomorphanen |
| CH1618967A CH449641A (de) | 1963-12-20 | 1964-11-30 | Verfahren zur Herstellung von neuen substituierten 6,7-Benzomorphanen |
| CH1618767A CH449639A (de) | 1963-12-20 | 1964-11-30 | Verfahren zur Herstellung von neuen substituierten 6,7-Benzomorphanen |
| CH1618867A CH449640A (de) | 1963-12-20 | 1964-11-30 | Verfahren zur Herstellung von neuen substituierten 6,7-Benzomorphanen |
| CH1619067A CH449642A (de) | 1963-12-20 | 1964-11-30 | Verfahren zur Herstellung von neuen substituierten 6,7-Benzomorphanen |
Country Status (12)
| Country | Link |
|---|---|
| AT (4) | AT249276B (de) |
| BE (2) | BE657406A (de) |
| CH (7) | CH446371A (de) |
| DE (2) | DE1445853A1 (de) |
| DK (4) | DK108497C (de) |
| ES (4) | ES307299A1 (de) |
| FR (2) | FR4345M (de) |
| GB (2) | GB1077711A (de) |
| IL (2) | IL22642A (de) |
| NL (3) | NL6414820A (de) |
| NO (2) | NO119273B (de) |
| SE (2) | SE322779B (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7501433B2 (en) | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US7923454B2 (en) | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| CN1653050B (zh) | 2002-05-17 | 2013-04-24 | 詹肯生物科学公司 | 阿片和阿片样化合物及其用途 |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| JP5486928B2 (ja) | 2007-02-26 | 2014-05-07 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックウレアおよびカルバメートインヒビター |
| JP5470557B2 (ja) | 2007-07-26 | 2014-04-16 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成 |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| CL2008003407A1 (es) | 2007-11-16 | 2010-01-11 | Boehringer Ingelheim Int | Compuestos derivados de aril- y heteroarilcarbonilo de heterobiciclo sustituido; composicion farmaceutica; procedimiento de preparacion; y su uso en el tratamiento y/o prevencion de trastornos metabolicos, mediado por la inhibicion de la enzima hsd-1. |
| JP5490014B2 (ja) | 2007-12-11 | 2014-05-14 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| US8592409B2 (en) | 2008-01-24 | 2013-11-26 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| EP2252598A2 (de) | 2008-02-11 | 2010-11-24 | Vitae Pharmaceuticals, Inc. | 1,3-oxazepan-2-on und 1,3-diazepan-2-on als inhibitoren von 11beta-hydroxysteroiddehydrogenase 1 |
| CA2711757C (en) * | 2008-02-12 | 2016-07-26 | Boehringer Ingelheim International Gmbh | Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| CA2715290A1 (en) | 2008-02-15 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2009134392A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8242111B2 (en) | 2008-05-01 | 2012-08-14 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| US8138178B2 (en) | 2008-05-01 | 2012-03-20 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CA2723034A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2288596B1 (de) | 2008-05-13 | 2016-11-30 | Boehringer Ingelheim International GmbH | Alizyklische carboxylsäurederivate von benzomorphanen, entsprechende gerüste, medikamente mit solchen verbindungen und ihre verwendung |
| TW201016691A (en) | 2008-07-25 | 2010-05-01 | Boehringer Ingelheim Int | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| KR20110050459A (ko) | 2008-07-25 | 2011-05-13 | 비타이 파마슈티컬즈, 인코포레이티드 | 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제 |
| US8829027B2 (en) | 2008-10-23 | 2014-09-09 | Boehringer Ingelheim International Gmbh | Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use |
| JP5679997B2 (ja) | 2009-02-04 | 2015-03-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| US8680093B2 (en) | 2009-04-30 | 2014-03-25 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| JP5670440B2 (ja) | 2009-06-02 | 2015-02-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| EP2440537A1 (de) | 2009-06-11 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Cyclische hemmer der 11beta-hydroxysteroiddehydrogenase 1 auf basis der 1,3 -oxazinan- 2 -on-struktur |
| US8883778B2 (en) | 2009-07-01 | 2014-11-11 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
| UY33001A (es) | 2009-11-06 | 2011-05-31 | Boehringer Ingelheim Int | Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina |
| EP2582698B1 (de) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituierte 5-,6- und 7-gliedrige heterocyclen, medikamente mit derartigen verbindungen und ihre verwendung |
| JP5813106B2 (ja) | 2010-06-25 | 2015-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン |
| EA201300522A1 (ru) | 2010-11-02 | 2013-11-29 | Бёрингер Ингельхайм Интернациональ Гмбх | Фармацевтические комбинации для лечения метаболических нарушений |
| TWI537258B (zh) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物 |
| US8735585B2 (en) | 2011-08-17 | 2014-05-27 | Boehringer Ingelheim International Gmbh | Indenopyridine derivatives |
-
0
- NL NL127995D patent/NL127995C/xx active
-
1964
- 1964-11-30 CH CH1538464A patent/CH446371A/de unknown
- 1964-11-30 CH CH1538364A patent/CH448118A/de unknown
- 1964-11-30 CH CH1618967A patent/CH449641A/de unknown
- 1964-11-30 CH CH1618767A patent/CH449639A/de unknown
- 1964-11-30 CH CH1618867A patent/CH449640A/de unknown
- 1964-11-30 CH CH1619067A patent/CH449642A/de unknown
- 1964-11-30 CH CH1619167A patent/CH449643A/de unknown
- 1964-12-18 IL IL2264264A patent/IL22642A/xx unknown
- 1964-12-18 DE DE19641445853 patent/DE1445853A1/de active Pending
- 1964-12-18 GB GB5149864A patent/GB1077711A/en not_active Expired
- 1964-12-18 NL NL6414820A patent/NL6414820A/xx unknown
- 1964-12-18 SE SE1536064A patent/SE322779B/xx unknown
- 1964-12-18 GB GB5150064A patent/GB1092394A/en not_active Expired
- 1964-12-18 AT AT392865A patent/AT249276B/de active
- 1964-12-18 IL IL2264364A patent/IL22643A/xx unknown
- 1964-12-18 AT AT392965A patent/AT249277B/de active
- 1964-12-18 AT AT1074364A patent/AT253687B/de active
- 1964-12-18 SE SE1536164A patent/SE305657B/xx unknown
- 1964-12-18 NL NL6414821A patent/NL6414821A/xx unknown
- 1964-12-18 DE DE19641445854 patent/DE1445854A1/de active Pending
- 1964-12-18 AT AT1074264A patent/AT261126B/de active
- 1964-12-19 DK DK429865A patent/DK108497C/da active
- 1964-12-19 DK DK626764A patent/DK108495C/da active
- 1964-12-19 NO NO15606264A patent/NO119273B/no unknown
- 1964-12-19 ES ES0307299A patent/ES307299A1/es not_active Expired
- 1964-12-19 DK DK429765A patent/DK108496C/da active
- 1964-12-19 NO NO15606364A patent/NO119274B/no unknown
- 1964-12-19 ES ES0307300A patent/ES307300A1/es not_active Expired
- 1964-12-19 DK DK626864A patent/DK106552C/da active
- 1964-12-19 ES ES0307301A patent/ES307301A1/es not_active Expired
- 1964-12-19 ES ES0307302A patent/ES307302A1/es not_active Expired
- 1964-12-21 BE BE657406D patent/BE657406A/xx unknown
- 1964-12-21 BE BE657405D patent/BE657405A/xx unknown
-
1965
- 1965-03-19 FR FR9865A patent/FR4345M/fr active Active
- 1965-03-19 FR FR9866A patent/FR4346M/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AT249276B (de) | 1966-09-12 |
| SE305657B (de) | 1968-11-04 |
| FR4346M (de) | 1966-08-16 |
| BE657405A (de) | 1965-06-21 |
| GB1092394A (en) | 1967-11-22 |
| AT261126B (de) | 1968-04-10 |
| DK106552C (da) | 1967-02-20 |
| GB1077711A (en) | 1967-08-02 |
| ES307299A1 (es) | 1965-05-16 |
| DK108495C (da) | 1967-12-27 |
| ES307300A1 (es) | 1965-05-01 |
| NO119274B (de) | 1970-04-27 |
| BE657406A (de) | 1965-06-21 |
| NL6414821A (de) | 1965-06-21 |
| IL22643A (en) | 1968-07-25 |
| CH448118A (de) | 1967-12-15 |
| AT253687B (de) | 1967-04-25 |
| FR4345M (de) | 1966-08-16 |
| CH446371A (de) | 1967-11-15 |
| NL127995C (de) | |
| CH449639A (de) | 1968-01-15 |
| DK108497C (da) | 1967-12-27 |
| ES307302A1 (es) | 1965-05-16 |
| CH449642A (de) | 1968-01-15 |
| DK108496C (da) | 1967-12-27 |
| NL6414820A (de) | 1965-06-21 |
| NO119273B (de) | 1970-04-27 |
| DE1445853A1 (de) | 1968-12-05 |
| AT249277B (de) | 1966-09-12 |
| IL22642A (en) | 1968-07-25 |
| SE322779B (de) | 1970-04-20 |
| ES307301A1 (es) | 1965-05-16 |
| CH449640A (de) | 1968-01-15 |
| CH449641A (de) | 1968-01-15 |
| DE1445854A1 (de) | 1968-12-05 |
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