CH393637A - Procédé de préparation de la psilocybine et de la psilocine - Google Patents

Procédé de préparation de la psilocybine et de la psilocine

Info

Publication number
CH393637A
CH393637A CH5614358A CH5614358A CH393637A CH 393637 A CH393637 A CH 393637A CH 5614358 A CH5614358 A CH 5614358A CH 5614358 A CH5614358 A CH 5614358A CH 393637 A CH393637 A CH 393637A
Authority
CH
Switzerland
Prior art keywords
sep
mycelium
water
psilocin
psilocybin
Prior art date
Application number
CH5614358A
Other languages
English (en)
French (fr)
Inventor
Hofmann Albert
Brack Arthur
Kobel Hans
Heim Roger
Cailleux Roger
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to LU36879D priority Critical patent/LU36879A1/xx
Priority to NL236150D priority patent/NL236150A/xx
Application filed by Sandoz Sa filed Critical Sandoz Sa
Priority to CH5614358A priority patent/CH393637A/fr
Priority to GB4841/59A priority patent/GB911946A/en
Priority to ES0247189A priority patent/ES247189A1/es
Priority to US793234A priority patent/US3183172A/en
Priority to FR787204A priority patent/FR1298308A/fr
Priority to GB912715D priority patent/GB912715A/en
Publication of CH393637A publication Critical patent/CH393637A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/078—Psilocybe
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/803—Physical recovery methods, e.g. chromatography, grinding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CH5614358A 1958-02-21 1958-02-21 Procédé de préparation de la psilocybine et de la psilocine CH393637A (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
LU36879D LU36879A1 (OSRAM) 1958-02-21
NL236150D NL236150A (OSRAM) 1958-02-21
CH5614358A CH393637A (fr) 1958-02-21 1958-02-21 Procédé de préparation de la psilocybine et de la psilocine
GB4841/59A GB911946A (en) 1958-02-21 1959-02-11 Psilocybin and psilocin and processes for their preparation
ES0247189A ES247189A1 (es) 1958-02-21 1959-02-12 Procedimiento para la obtencion de psilobicina y psilocina
US793234A US3183172A (en) 1958-02-21 1959-02-16 Obtaining psilocybin and psilocin from fungal material
FR787204A FR1298308A (fr) 1958-02-21 1959-02-19 Procédé d'obtention de la psilocybine et de la psilocine
GB912715D GB912715A (en) 1958-02-21 1959-08-24 4-hydroxytryptamines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH5614358A CH393637A (fr) 1958-02-21 1958-02-21 Procédé de préparation de la psilocybine et de la psilocine

Publications (1)

Publication Number Publication Date
CH393637A true CH393637A (fr) 1965-06-15

Family

ID=4520325

Family Applications (1)

Application Number Title Priority Date Filing Date
CH5614358A CH393637A (fr) 1958-02-21 1958-02-21 Procédé de préparation de la psilocybine et de la psilocine

Country Status (4)

Country Link
US (1) US3183172A (OSRAM)
CH (1) CH393637A (OSRAM)
ES (1) ES247189A1 (OSRAM)
LU (1) LU36879A1 (OSRAM)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
US12459965B2 (en) 2017-10-09 2025-11-04 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
WO2020212952A1 (en) 2019-04-17 2020-10-22 Compass Pathfinder Limited Treatment of depression and other various disorders with psilocybin
WO2021253116A1 (en) 2020-06-17 2021-12-23 Psilo Scientific Ltd Compositions comprising psychoactive compounds from psychoactive organisms
JP2022550463A (ja) 2019-10-01 2022-12-01 エンピリアン ニューロサイエンス， インコーポレイテッド トリプタミン発現を調整する真菌の遺伝子操作
WO2021188870A1 (en) * 2020-03-20 2021-09-23 Orthogonal Thinker, Inc. Psilocybin and psilocin containing compositions and methods of using and making the same
EP4161546A4 (en) 2020-06-17 2024-10-09 Psilo Scientific Ltd COMPOSITIONS COMPRISING PSYCHOACTIVE COMPOUNDS FROM PSYCHOACTIVE ORGANISMS
US12233355B2 (en) 2020-06-17 2025-02-25 Psilo Scientific Ltd. Methanol-based extraction of psychoactive alkaloids from fungus
US11382942B2 (en) 2020-06-17 2022-07-12 Psilo Scientific Ltd. Extraction of psychoactive compounds from psilocybin fungus
CA3124367C (en) 2020-06-17 2022-04-26 Psilo Scientific Ltd. Aqueous extraction of psychoactive compounds from psilocybin fungus
US11510952B2 (en) 2020-06-17 2022-11-29 Psilo Scientific Ltd. Ethanol extraction of psychoactive compounds from psilocybin fungus
US20230286916A1 (en) * 2020-07-24 2023-09-14 Mindset Pharma Inc. Scalable synthetic route for psilocin and psilocybin
CA3113240C (en) 2020-12-28 2023-09-05 Psilo Scientific Ltd. Transmucosal psychoactive alkaloid composition and preparation thereof
CA3133547C (en) 2021-10-07 2024-07-02 Psilo Scientific Ltd Liquid-liquid extraction of purified psychoactive alkaloid
WO2023130078A2 (en) 2021-12-31 2023-07-06 Empyrean Neuroscience, Inc. Genetically modified mycelium for producing psychotropic alkaloids
GB202313750D0 (en) * 2023-09-08 2023-10-25 Psyence Group Inc A process for obtaining a purified psychoactive alkaloid

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1632312A (en) * 1924-01-25 1927-06-14 Frederick C Raeth Process of converting chemical fertilizers to yeast and other organic substances
US2422230A (en) * 1943-09-11 1947-06-17 Merck & Co Inc Production of streptothricin
US2825734A (en) * 1955-04-11 1958-03-04 Upjohn Co Reduction of carbonylic radicals in indolyl-3 compounds
US2850520A (en) * 1956-07-18 1958-09-02 Sandoz Ag New water-insoluble styryl dyestuffs
US2850518A (en) * 1956-07-30 1958-09-02 Monsanto Chemicals Amino acid derivatives
US2955073A (en) * 1958-06-02 1960-10-04 Burroughs Wellcome Co Method of treating febrile convulsions
US2997422A (en) * 1959-01-09 1961-08-22 Smith Kline French Lab Monoamine oxidase inhibition

Also Published As

Publication number Publication date
US3183172A (en) 1965-05-11
LU36879A1 (OSRAM)
ES247189A1 (es) 1959-10-16

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