ES247189A1 - Procedimiento para la obtencion de psilobicina y psilocina - Google Patents
Procedimiento para la obtencion de psilobicina y psilocinaInfo
- Publication number
- ES247189A1 ES247189A1 ES0247189A ES247189A ES247189A1 ES 247189 A1 ES247189 A1 ES 247189A1 ES 0247189 A ES0247189 A ES 0247189A ES 247189 A ES247189 A ES 247189A ES 247189 A1 ES247189 A1 ES 247189A1
- Authority
- ES
- Spain
- Prior art keywords
- psilocin
- psilocybin
- fungi
- obtaining
- natural
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000463 material Substances 0.000 title abstract 3
- SPCIYGNTAMCTRO-UHFFFAOYSA-N Psilocine Natural products C1=CC(O)=C2C(CCN(C)C)=CNC2=C1 SPCIYGNTAMCTRO-UHFFFAOYSA-N 0.000 title abstract 2
- QVDSEJDULKLHCG-UHFFFAOYSA-N Psilocybine Natural products C1=CC(OP(O)(O)=O)=C2C(CCN(C)C)=CNC2=C1 QVDSEJDULKLHCG-UHFFFAOYSA-N 0.000 title abstract 2
- ZBWSBXGHYDWMAK-UHFFFAOYSA-N psilocin Chemical compound C1=CC=C(O)[C]2C(CCN(C)C)=CN=C21 ZBWSBXGHYDWMAK-UHFFFAOYSA-N 0.000 title abstract 2
- QKTAAWLCLHMUTJ-UHFFFAOYSA-N psilocybin Chemical compound C1C=CC(OP(O)(O)=O)=C2C(CCN(C)C)=CN=C21 QKTAAWLCLHMUTJ-UHFFFAOYSA-N 0.000 title abstract 2
- 230000002538 fungal effect Effects 0.000 title 1
- 241000233866 Fungi Species 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 235000010633 broth Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000011534 incubation Methods 0.000 abstract 1
- 238000011081 inoculation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 230000000506 psychotropic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/803—Physical recovery methods, e.g. chromatography, grinding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Procedimiento para la obtención de psilocibina y psilocinade efecto psicotrópicoen estado purocompuestos hasta ahora desconocidosde ciertas clases de hongoscaracterizado porque de material funginoso de origen natural de los géneros psilocybestrophatiapanaeolusconocybeamanita o Russulao de material funginoso cultivado artificialmenteobtenido de cultivos de las distintas clases de estos hongos a sus variantes biológicas o mutaciones mediante inoculación de caldos naturales o artificiales e incubación de estos cultivos a la luz del día o a la oscuridad con una temperatura constante entre 18º y 27ºse extraen las materias activas según métodos conocidosse limpianse separan entre sí yen caso dado se liberan del halógeno.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH5614358A CH393637A (fr) | 1958-02-21 | 1958-02-21 | Procédé de préparation de la psilocybine et de la psilocine |
Publications (1)
Publication Number | Publication Date |
---|---|
ES247189A1 true ES247189A1 (es) | 1959-10-16 |
Family
ID=4520325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES0247189A Expired ES247189A1 (es) | 1958-02-21 | 1959-02-12 | Procedimiento para la obtencion de psilobicina y psilocina |
Country Status (4)
Country | Link |
---|---|
US (1) | US3183172A (es) |
CH (1) | CH393637A (es) |
ES (1) | ES247189A1 (es) |
LU (1) | LU36879A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
CN113993523A (zh) | 2019-04-17 | 2022-01-28 | 指南针探路者有限公司 | 用赛洛西宾治疗抑郁症和其他各种病症 |
EP4038192A4 (en) | 2019-10-01 | 2023-11-01 | Empyrean Neuroscience, Inc. | GENETIC MANIPULATION OF MUSHROOMS TO MODULATE TRYPTAMINE EXPRESSION |
WO2021188870A1 (en) * | 2020-03-20 | 2021-09-23 | Orthogonal Thinker, Inc. | Psilocybin and psilocin containing compositions and methods of using and making the same |
US11510952B2 (en) | 2020-06-17 | 2022-11-29 | Psilo Scientific Ltd. | Ethanol extraction of psychoactive compounds from psilocybin fungus |
US11382942B2 (en) | 2020-06-17 | 2022-07-12 | Psilo Scientific Ltd. | Extraction of psychoactive compounds from psilocybin fungus |
CA3173030C (en) | 2020-06-17 | 2024-05-14 | Psilo Scientific Ltd. | Predominantly phosphorylated psychoactive alkaloid extraction using alkali |
CA3123908C (en) | 2020-06-17 | 2022-03-22 | Psilo Scientific Ltd. | Ethanol extraction of psychoactive compounds from psilocybin fungus |
IL299450A (en) | 2020-06-17 | 2023-02-01 | Psilo Scient Ltd | Dephosphorylation-controlled extraction of phosphorylatable psychoactive alkaloids |
AU2021311493A1 (en) * | 2020-07-24 | 2023-03-16 | Mindset Pharma Inc. | Scalable synthetic route for psilocin and psilocybin |
CA3197443A1 (en) | 2020-12-28 | 2022-06-28 | Psilo Scientific Ltd. | Processes for extracting psychoactive alkaloids and preparation thereof into transmucosal forms |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1632312A (en) * | 1924-01-25 | 1927-06-14 | Frederick C Raeth | Process of converting chemical fertilizers to yeast and other organic substances |
US2422230A (en) * | 1943-09-11 | 1947-06-17 | Merck & Co Inc | Production of streptothricin |
US2825734A (en) * | 1955-04-11 | 1958-03-04 | Upjohn Co | Reduction of carbonylic radicals in indolyl-3 compounds |
US2850520A (en) * | 1956-07-18 | 1958-09-02 | Sandoz Ag | New water-insoluble styryl dyestuffs |
US2850518A (en) * | 1956-07-30 | 1958-09-02 | Monsanto Chemicals | Amino acid derivatives |
US2955073A (en) * | 1958-06-02 | 1960-10-04 | Burroughs Wellcome Co | Method of treating febrile convulsions |
US2997422A (en) * | 1959-01-09 | 1961-08-22 | Smith Kline French Lab | Monoamine oxidase inhibition |
-
0
- LU LU36879D patent/LU36879A1/xx unknown
-
1958
- 1958-02-21 CH CH5614358A patent/CH393637A/fr unknown
-
1959
- 1959-02-12 ES ES0247189A patent/ES247189A1/es not_active Expired
- 1959-02-16 US US793234A patent/US3183172A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CH393637A (fr) | 1965-06-15 |
US3183172A (en) | 1965-05-11 |
LU36879A1 (es) |
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