CH284262A - Process for the preparation of 4-chloro-2-amino-6-methylpyrimidine-1-metho-p-toluenesulfonate. - Google Patents

Process for the preparation of 4-chloro-2-amino-6-methylpyrimidine-1-metho-p-toluenesulfonate.

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Publication number
CH284262A
CH284262A CH284262DA CH284262A CH 284262 A CH284262 A CH 284262A CH 284262D A CH284262D A CH 284262DA CH 284262 A CH284262 A CH 284262A
Authority
CH
Switzerland
Prior art keywords
chloro
amino
methylpyrimidine
metho
toluenesulfonate
Prior art date
Application number
Other languages
German (de)
Inventor
Limited Imperial Ch Industries
Original Assignee
Ici Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Ltd filed Critical Ici Ltd
Publication of CH284262A publication Critical patent/CH284262A/en

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Description

  

  <B>Verfahren zur Herstellung von</B>     4-Chlor-2-amino-6-methylpyrimidin-l-metho-p-          toluolsulfonat.       Gegenstand der vorliegenden Erfindung  ist ein Verfahren zur Herstellung von       4-Chlor-2-amino-6-methylpyrimidin-l-metho-p-          toluolsulfonat,    welches dadurch gekennzeich  net ist, dass     4-Chlor-2-amino-6-methylpyrimi-          din    mit     Methyl-p-toluolsulfonat    zur Reaktion  gebracht wird.  



  Die Reaktion kann durch Erhitzen der ver  einigten Reaktionsteilnehmer, zweckmässiger  weise in Gegenwart eines Lösungsmittels, wie  z. B.     fl-Äthozyäthanol,    Äthanol, Nitrobenzol,       Nitroäthan    oder     Äthylessigester,    ausgeführt  werden.  



  Das neue     quaternäre    Salz eignet sich für  die Herstellung von Chemotherapeutika und  insbesondere von neuen     trypanoziden    Mitteln.  Es kann, wenn gewünscht, nach einfachen  Verfahren der doppelten Umsetzung in     qua-          ternäre    Salze mit einem andern Anion über  geführt werden.  



  Im folgenden Beispiel sollen unter  Teile        Gewichtsteile    verstanden werden.  



  <I>Beispiel:</I>  Man vermischt 15 Teile     4-Chlor-2-amino-6-          methyl-pyrimidin,    72 Teile Nitrobenzol und 22  Teile     Methyl-p-toluolsulfonat    und rührt und  erhitzt das     Gxemisch    während 4,5 Stunden bei  93 bis 97  C. Das Gemisch wird hierauf abge-    kühlt und filtriert, worauf der feste Rück  stand mit Aceton gewaschen und aus     n-Pro-          pylalkohol    zum Kristallisieren gebracht wird.

         4-Chlor-2-amino-6-methyl-pyrimidin    -     I.    -     metho-          p-toluolsulfonat    wird in Form nahezu farb  loser Nadeln vom     Smp.    200 bis 201  C erhalten.



  <B> Process for the preparation of </B> 4-chloro-2-amino-6-methylpyrimidine-1-metho-p-toluenesulfonate. The present invention relates to a process for the preparation of 4-chloro-2-amino-6-methylpyrimidine-1-metho-p-toluenesulfonate, which is characterized in that 4-chloro-2-amino-6-methylpyrimidine is reacted with methyl p-toluenesulfonate.



  The reaction can be carried out by heating the united reactants ver, conveniently in the presence of a solvent, such as. B. fl-Ethozyäthanol, ethanol, nitrobenzene, nitroethane or ethyl acetate, are executed.



  The new quaternary salt is suitable for the production of chemotherapeutic agents and in particular of new trypanocidal agents. If desired, it can be converted into quaternary salts with a different anion by simple processes of double conversion.



  In the following example, parts are to be understood as parts by weight.



  <I> Example: </I> 15 parts of 4-chloro-2-amino-6-methyl-pyrimidine, 72 parts of nitrobenzene and 22 parts of methyl p-toluenesulfonate are mixed, and the mixture is stirred and heated for 4.5 hours 93 to 97 C. The mixture is then cooled and filtered, whereupon the solid residue is washed with acetone and crystallized from n-propyl alcohol.

         4-chloro-2-amino-6-methyl-pyrimidine - I. - metho- p-toluenesulphonate is obtained in the form of almost colorless needles with a melting point of 200 to 201.degree.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von 4-Chlor-2 amino-6-methyl-pyrimidin-l-metho-p-toluolsul- fonat, dadurch gekennzeichnet, dass 4-Chlor-2- amino-6-methylpyrimidin mit Methyl-p-toluol- sulfonat zur Umsetzung gebracht wird. 4-Chlor-2-amino-6 -methylpyrimidin -1-me- tho-p-toluolsulfonat ist ein nahezu farbloses, kristallisiertes, festes Produkt vom Smp. 200 bis 201 C. PATENT CLAIM: Process for the preparation of 4-chloro-2-amino-6-methyl-pyrimidine-1-metho-p-toluene sulfonate, characterized in that 4-chloro-2-amino-6-methylpyrimidine with methyl-p-toluene - sulfonate is brought to implementation. 4-chloro-2-amino-6-methylpyrimidine -1-metho-p-toluenesulfonate is an almost colorless, crystallized, solid product with a melting point of 200 to 201 C. Es kann durch doppelte Umsetzung in 4-Chlor-2-amino-6-methylpyrimidin-Salze mit andern Anionen übergeführt und als Zwi schenprodukt bei der Herstellung von Chemo- therapeutika, insbesondere von trypanoziden Mitteln, verwendet werden. UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass die Reaktion durch Er hitzen der vereinigten Reaktionsteilnehmer in einem Lösungsmittel ausgeführt wird. It can be converted into 4-chloro-2-amino-6-methylpyrimidine salts with other anions by double conversion and used as an intermediate in the manufacture of chemotherapeutic agents, in particular trypanocidal agents. SUBClaim: The method according to claim, characterized in that the reaction is carried out by heating the combined reactants in a solvent.
CH284262D 1947-08-22 1948-08-21 Process for the preparation of 4-chloro-2-amino-6-methylpyrimidine-1-metho-p-toluenesulfonate. CH284262A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB284262X 1947-08-22
CH270254T 1948-08-21

Publications (1)

Publication Number Publication Date
CH284262A true CH284262A (en) 1952-07-15

Family

ID=25731154

Family Applications (1)

Application Number Title Priority Date Filing Date
CH284262D CH284262A (en) 1947-08-22 1948-08-21 Process for the preparation of 4-chloro-2-amino-6-methylpyrimidine-1-metho-p-toluenesulfonate.

Country Status (1)

Country Link
CH (1) CH284262A (en)

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