CH261826A - Process for the preparation of a substituted 2,4-diamino-1,3,5-triazine. - Google Patents
Process for the preparation of a substituted 2,4-diamino-1,3,5-triazine.Info
- Publication number
- CH261826A CH261826A CH261826DA CH261826A CH 261826 A CH261826 A CH 261826A CH 261826D A CH261826D A CH 261826DA CH 261826 A CH261826 A CH 261826A
- Authority
- CH
- Switzerland
- Prior art keywords
- triazine
- ethyl
- benzyl
- diamino
- substituted
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
<B>Verfahren zur Herstellung eines substituierten</B> 2,4-Diamino-1,3,5.triazins. Gegenstand vorliegenden Patentes bildet ein Verfahren zur Herstellung eines substi tuierten 2,4-Diamino-1,3,5-triazins. Das Ver fahren ist dadurch gekennzeichnet, dass man 1-Äthyl-l-benzyl-biguanid mit einer zur Tri- azinringbildung geeigneten, den Rest HC=ab- gebenden Verbindung, wie z.
B. mit Ameisen säureester, Formamid, Formamidin, Chloro form, Orthoameisensäureester, zum 2-Amino- 4-N-äthyl-N-benzyl-amino-1,3,5-triazin um setzt. Die erhaltene neue Base stellt ein weisses, kristallines Pulver dar, das bei 86 bis 86,50 schmilzt. Sie soll als Heilmittel oder Zwischen produkt für die Herstellung von Heilmitteln verwendet werden.
<I>Beispiel:</I> 26,3 Teile neutrales 1-Äthyl-l-benzyl-bigua- nid-sulfat werden mit 2,3 Teilen Natrium und 8 Teilen Ä thylformiat umgesetzt. Das Reak tionsgemisch wird nach Abkühlen abgesaugt und das alkoholische Filtrat eingedampft; das zurückbleibende Öl wird mit heissem Wasser verrührt und mit Natronlauge alkalisch ge stellt; nach einigen Stunden erstarrt das Öl zu einer harten Kristallmasse; diese wird aus verdünntem Methylalkohol (2 Teile Methyl- alkohol und 1 Teil Wasser) unter Verwen dung von Tierkohle heiss umkristallisiert.
Zur Herstellung der gleichen Verbindung kann man auch 1-Äthyl-l-benzyl-biguanid mit Formamid reagieren lassen.
<B> Process for the preparation of a substituted </B> 2,4-diamino-1,3,5-triazine. The subject of the present patent forms a process for the preparation of a substituted 2,4-diamino-1,3,5-triazine. The process is characterized in that 1-ethyl-1-benzyl-biguanide is mixed with a compound which is suitable for triazine ring formation and which gives off the remainder of HC, such as.
B. with formic acid esters, formamide, formamidine, chloro form, orthoformic acid esters, for 2-amino-4-N-ethyl-N-benzyl-amino-1,3,5-triazine. The new base obtained is a white, crystalline powder that melts at 86 to 86.50. It is intended to be used as a remedy or an intermediate in the manufacture of medicines.
<I> Example: </I> 26.3 parts of neutral 1-ethyl-1-benzyl-biguanide sulfate are reacted with 2.3 parts of sodium and 8 parts of ethyl formate. The reaction mixture is filtered off with suction after cooling and the alcoholic filtrate is evaporated; the remaining oil is stirred with hot water and made alkaline with sodium hydroxide solution; after a few hours the oil solidifies to a hard crystal mass; this is recrystallized from dilute methyl alcohol (2 parts methyl alcohol and 1 part water) using animal charcoal.
To produce the same compound, 1-ethyl-1-benzyl-biguanide can also be reacted with formamide.
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH261826T | 1946-08-16 | ||
CH254538T | 1946-08-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH261826A true CH261826A (en) | 1949-05-31 |
Family
ID=25729837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH261826D CH261826A (en) | 1946-08-16 | 1946-08-16 | Process for the preparation of a substituted 2,4-diamino-1,3,5-triazine. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH261826A (en) |
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1946
- 1946-08-16 CH CH261826D patent/CH261826A/en unknown
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