CH261826A - Process for the preparation of a substituted 2,4-diamino-1,3,5-triazine. - Google Patents

Process for the preparation of a substituted 2,4-diamino-1,3,5-triazine.

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Publication number
CH261826A
CH261826A CH261826DA CH261826A CH 261826 A CH261826 A CH 261826A CH 261826D A CH261826D A CH 261826DA CH 261826 A CH261826 A CH 261826A
Authority
CH
Switzerland
Prior art keywords
triazine
ethyl
benzyl
diamino
substituted
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH261826A publication Critical patent/CH261826A/en

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Description

  

  <B>Verfahren zur Herstellung eines substituierten</B>     2,4-Diamino-1,3,5.triazins.       Gegenstand vorliegenden Patentes bildet  ein Verfahren zur Herstellung eines substi  tuierten     2,4-Diamino-1,3,5-triazins.    Das Ver  fahren ist dadurch gekennzeichnet, dass man       1-Äthyl-l-benzyl-biguanid    mit einer zur     Tri-          azinringbildung    geeigneten, den Rest     HC=ab-          gebenden    Verbindung, wie z.

   B. mit Ameisen  säureester,     Formamid,        Formamidin,    Chloro  form,     Orthoameisensäureester,    zum     2-Amino-          4-N-äthyl-N-benzyl-amino-1,3,5-triazin    um  setzt. Die erhaltene neue Base stellt ein weisses,  kristallines Pulver dar, das bei 86 bis 86,50  schmilzt. Sie soll als Heilmittel oder Zwischen  produkt für die Herstellung von Heilmitteln       verwendet    werden.  



  <I>Beispiel:</I>  26,3 Teile neutrales     1-Äthyl-l-benzyl-bigua-          nid-sulfat    werden mit 2,3 Teilen Natrium und  8 Teilen Ä     thylformiat    umgesetzt. Das Reak  tionsgemisch wird nach Abkühlen abgesaugt  und das alkoholische Filtrat eingedampft; das  zurückbleibende Öl wird mit heissem Wasser  verrührt und mit Natronlauge alkalisch ge  stellt; nach einigen Stunden erstarrt das Öl  zu einer harten Kristallmasse; diese wird aus  verdünntem Methylalkohol (2 Teile Methyl-         alkohol    und 1 Teil Wasser) unter Verwen  dung von Tierkohle heiss umkristallisiert.  



  Zur Herstellung der gleichen     Verbindung     kann man auch     1-Äthyl-l-benzyl-biguanid    mit       Formamid    reagieren lassen.



  <B> Process for the preparation of a substituted </B> 2,4-diamino-1,3,5-triazine. The subject of the present patent forms a process for the preparation of a substituted 2,4-diamino-1,3,5-triazine. The process is characterized in that 1-ethyl-1-benzyl-biguanide is mixed with a compound which is suitable for triazine ring formation and which gives off the remainder of HC, such as.

   B. with formic acid esters, formamide, formamidine, chloro form, orthoformic acid esters, for 2-amino-4-N-ethyl-N-benzyl-amino-1,3,5-triazine. The new base obtained is a white, crystalline powder that melts at 86 to 86.50. It is intended to be used as a remedy or an intermediate in the manufacture of medicines.



  <I> Example: </I> 26.3 parts of neutral 1-ethyl-1-benzyl-biguanide sulfate are reacted with 2.3 parts of sodium and 8 parts of ethyl formate. The reaction mixture is filtered off with suction after cooling and the alcoholic filtrate is evaporated; the remaining oil is stirred with hot water and made alkaline with sodium hydroxide solution; after a few hours the oil solidifies to a hard crystal mass; this is recrystallized from dilute methyl alcohol (2 parts methyl alcohol and 1 part water) using animal charcoal.



  To produce the same compound, 1-ethyl-1-benzyl-biguanide can also be reacted with formamide.

 

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines substi tuierten 2,4-Diamino-1,3,5-triazins, dadurch gekennzeichnet, dass man 1-Äthyl-l-benzyl-bi- guanid mit einer zur Triazinringbildung ge eigneten, den Rest HC- abgebenden Verbin dung zum 2-Amino-4-N-äthyl-N-benzyl-amino- 1,3,5-triazin umsetzt. Die erhaltene neue Base stellt ein weisses, kristallines Pulver dar, das bei 86 bis 86,50 schmilzt. UNTERANSPRÜCHE: 1. PATENT CLAIM: A process for the production of a substituted 2,4-diamino-1,3,5-triazine, characterized in that 1-ethyl-1-benzyl-biguanide with a suitable for triazine ring formation, releases the remainder HC Connection to the 2-amino-4-N-ethyl-N-benzyl-amino-1,3,5-triazine implemented. The new base obtained is a white, crystalline powder that melts at 86 to 86.50. SUBCLAIMS: 1. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man 1-Äthyl-l- benzyl-biguanid mit einem Ameisensäureester umsetzt. 2. Verfahren nach Patentanspruch, da durch gekennzeichnet, dass man 1-Äthyl-l- benzyl-biguanid mit Formamid umsetzt. Process according to patent claim, characterized in that 1-ethyl-1-benzyl biguanide is reacted with a formic acid ester. 2. The method according to claim, characterized in that 1-ethyl-1-benzyl biguanide is reacted with formamide.
CH261826D 1946-08-16 1946-08-16 Process for the preparation of a substituted 2,4-diamino-1,3,5-triazine. CH261826A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH261826T 1946-08-16
CH254538T 1946-08-16

Publications (1)

Publication Number Publication Date
CH261826A true CH261826A (en) 1949-05-31

Family

ID=25729837

Family Applications (1)

Application Number Title Priority Date Filing Date
CH261826D CH261826A (en) 1946-08-16 1946-08-16 Process for the preparation of a substituted 2,4-diamino-1,3,5-triazine.

Country Status (1)

Country Link
CH (1) CH261826A (en)

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