CH261829A - Process for the preparation of a substituted 2,4-diamino-1,3,5-triazine. - Google Patents
Process for the preparation of a substituted 2,4-diamino-1,3,5-triazine.Info
- Publication number
- CH261829A CH261829A CH261829DA CH261829A CH 261829 A CH261829 A CH 261829A CH 261829D A CH261829D A CH 261829DA CH 261829 A CH261829 A CH 261829A
- Authority
- CH
- Switzerland
- Prior art keywords
- triazine
- diamino
- substituted
- preparation
- biguanide
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung eines substituierten 2,4-Diamino-1,3,5-triazins. Gegenstand vorliegenden Patentes bildet ein Verfahren zur Herstellung eines substi tuierten 2,4-Diamino-1,3,5-triazins. Das Ver fahren ist dadurch gekennzeichnet, dass man 1-n-Propyl-biguanid mit einer zur Triazin- ringbildung geeigneten, den Rest HC= ab gebenden Verbindung, wie z.
B. mit Ameisen säureester, Formamid, Formamidin, Chloro form, Orthoameisensäureester, zum 2-Amino- 4-n-propylamino-1,3,5-triazin umsetzt. Die er haltene neue Base schmilzt bei 1680 und soll als Heilmittel oder Zwischenprodukt für die Herstellung von Heilmitteln verwendet wer den.
Beispiel: 24,1 Teile saures 1-n-Propyl-biguanidsul- fat werden fein gepulvert und in 80 Teilen Äthylalkohol suspendiert. Unter Rühren und Überleiten von Stickstoff lässt man eine noch warme Lösung von 4,6 Teilen Natrium in 60 Teilen Äthy lalkohol zufliessen, rührt eine halbe Stunde bei 40 bis 600, kühlt auf 200 ab und gibt auf einmal 8 Teile Äthylformiat zu;
die Temperatur steigt auf etwa 30 . Nach Ab klingen der Reaktion wird noch eine Stunde bei 60 bis 700 gerührt, erkalten gelassen und abgenutscht. Das Nutschgut wird in 150 Vol.- Teilen kochendem Wasser unter Zugabe eini- ger Tropfen Natronlauge kurz aufgekocht, gekühlt, abgesaugt und das Nutschgut aus kochend heissem Methylalkohol umkristalli siert; das erhaltene 2-Amino-4-n-propylamino- 1,3,5-triazin schmilzt bei 16811.
Zu der gleichen Verbindung gelangt man durch Umsetzung von 1-n-Propyl-biguanid mit Formamid.
Process for the preparation of a substituted 2,4-diamino-1,3,5-triazine. The subject of the present patent forms a process for the preparation of a substituted 2,4-diamino-1,3,5-triazine. The Ver drive is characterized in that 1-n-propyl biguanide with a suitable for triazine ring formation, the remainder HC = from giving compound such.
B. with formic acid ester, formamide, formamidine, chloro form, orthoformic acid ester, to the 2-amino-4-n-propylamino-1,3,5-triazine. The new base he received melts in 1680 and is said to be used as a remedy or intermediate in the manufacture of remedies.
Example: 24.1 parts of acidic 1-n-propyl biguanide sulfate are finely powdered and suspended in 80 parts of ethyl alcohol. While stirring and passing nitrogen over it, a still warm solution of 4.6 parts of sodium in 60 parts of ethyl alcohol is allowed to flow in, the mixture is stirred for half an hour at 40 to 600, cooled to 200 and 8 parts of ethyl formate are added at once;
the temperature rises to about 30. After the reaction has subsided, the mixture is stirred for a further hour at 60 to 700, allowed to cool and suction filtered. The filter material is briefly boiled in 150 parts by volume of boiling water with the addition of a few drops of sodium hydroxide solution, cooled, suctioned off and the filter material is recrystallized from boiling hot methyl alcohol; the 2-amino-4-n-propylamino-1,3,5-triazine obtained melts at 16811.
The same compound is obtained by reacting 1-n-propyl biguanide with formamide.
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH261829T | 1946-08-16 | ||
CH254538T | 1946-08-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH261829A true CH261829A (en) | 1949-05-31 |
Family
ID=25729840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH261829D CH261829A (en) | 1946-08-16 | 1946-08-16 | Process for the preparation of a substituted 2,4-diamino-1,3,5-triazine. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH261829A (en) |
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1946
- 1946-08-16 CH CH261829D patent/CH261829A/en unknown
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