CH242950A - Process for the preparation of an N-substituted imino-di-fatty acid amide. - Google Patents

Process for the preparation of an N-substituted imino-di-fatty acid amide.

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Publication number
CH242950A
CH242950A CH242950DA CH242950A CH 242950 A CH242950 A CH 242950A CH 242950D A CH242950D A CH 242950DA CH 242950 A CH242950 A CH 242950A
Authority
CH
Switzerland
Prior art keywords
sep
imino
fatty acid
acid amide
preparation
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH242950A publication Critical patent/CH242950A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Herstellung eines     N-substituierten        lmino-cli-fettsäureamides.       Gegenstand vorliegenden Patentes ist ein  Verfahren zur     Herstellung    eines     N-substi-          tuierten        Imino-di-fettsäureamides..    Das Ver  fahren ist dadurch gekennzeichnet, dass man  ein N-     (n-But@=1)        -imino-a,a'-dipropionsäure-          amid,    das in den     Amidgruppen    noch ersetz  baren Wasserstoff enthält, mit einem     Methv-          lierungsmittel    zum     N-(n-Butyl)-imino-a,

  ai        -          dipropionsäure-bis-dimethylamicl    umsetzt.  



  Die neue Verbindung soll als Arzneimit  tel Verwendung finden.  



  <I>Beispiel:</I>  26 Teile     N-(n-Butyl)-imino-a,ä        -dipropion-          s@iure-methvlamid-dimethvlamid    werden in       Yy        lol    gelöst, 4 Teile     Natriumamid    eingetra  gen und einige Zeit auf dem     'Wasserbad    er  wärmt, bis kein Ammoniak mehr     entweicht.     Dann wird die     Natriumverbindung    im Auto  klaven mit 15 Teilen     Kaliummethylsulfatauf          180=---190'    erhitzt.

   Nach Abtrennen des  
EMI0001.0027     
  
    Natriumkaliumsulfates <SEP> wird <SEP> vom <SEP> Lösungs-       Der Siedepunkt des neuen, in Wasser und or  ganischen Lösungsmitteln löslichen Stoffes  liegt unter 0,09     min    Druck bei     132-135 .  



  Process for the preparation of an N-substituted imino-cli-fatty acid amide. The present patent relates to a process for the preparation of an N-substituted imino-di-fatty acid amide. The process is characterized in that an N- (n-But @ = 1) -imino-a, a'-dipropionic acid is used - amide, which still contains replaceable hydrogen in the amide groups, with a methylating agent to form N- (n-butyl) -imino-a,

  ai - dipropionic acid bis-dimethylamicl converts.



  The new compound is to be used as a drug.



  <I> Example: </I> 26 parts of N- (n-butyl) -imino-a, ä -dipropion- s @ iure-methvlamid-dimethvlamid are dissolved in yylene, 4 parts of sodium amide are entered and for some time on the 'The water bath warms up until no more ammonia escapes. The sodium compound is then heated in the car with 15 parts of potassium methyl sulfate to 180 = --- 190 '.

   After removing the
EMI0001.0027
  
    Sodium potassium sulfate <SEP> becomes <SEP> from the <SEP> solution. The boiling point of the new substance, which is soluble in water and organic solvents, is 132-135 under 0.09 min pressure.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines N-.sub- stituierten Imino-di-fettsäurea.mides, dadurch gekennzeichnet, dass man ein N-(n-Blity1)- imino-a,ä -dipropionsäureamid, das in den Amidgruppen noch ersetzbaren Wasserstoff cnthält, mit einem 1Hethylierungsmittel zum N-(n-Butyl)-imino-a.ä - dipropionsäure-bis-di- methylamid umsetzt. PATENT CLAIM: A process for the production of an N-substituted imino-di-fatty acid a.mide, characterized in that an N- (n-Blity1) -imino-α, α-dipropionic acid amide which still contains replaceable hydrogen in the amide groups , with a 1-ethylating agent to form N- (n-butyl) -imino-a.ä - dipropionic acid-bis-dimethylamide. Die neue Verbindung bildet ein fast farb loses<B>01</B> vom Siedepunkt 132-135 unter einem Druelz von 0,09 mrri Hg. Sie ist in -9rasser und organischen Lösiiiigsrriitteln lös lich und bildet mit Säuren wasserlösliche Salze. UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch EMI0001.0052 Y;(@lcennzeiclinet, <SEP> dass <SEP> man <SEP> in <SEP> Gegenwart <SEP> eines The new compound forms an almost colorless 01 with a boiling point of 132-135 under a pressure of 0.09 millimolar mercury. It is soluble in water and organic solvents and forms water-soluble salts with acids. SUBClaim: Method according to claim, thereby EMI0001.0052 Y; (@ lcennzeiclinet, <SEP> that <SEP> man <SEP> in <SEP> present <SEP> one
CH242950D 1943-05-13 1943-05-13 Process for the preparation of an N-substituted imino-di-fatty acid amide. CH242950A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH242950T 1943-05-13

Publications (1)

Publication Number Publication Date
CH242950A true CH242950A (en) 1946-06-15

Family

ID=4463273

Family Applications (1)

Application Number Title Priority Date Filing Date
CH242950D CH242950A (en) 1943-05-13 1943-05-13 Process for the preparation of an N-substituted imino-di-fatty acid amide.

Country Status (1)

Country Link
CH (1) CH242950A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3048620A (en) * 1959-08-03 1962-08-07 Geigy Chem Corp Tertiary amino alkylated amides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3048620A (en) * 1959-08-03 1962-08-07 Geigy Chem Corp Tertiary amino alkylated amides

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