CH210792A - Process for the preparation of a benzene sulfamide derivative. - Google Patents
Process for the preparation of a benzene sulfamide derivative.Info
- Publication number
- CH210792A CH210792A CH210792DA CH210792A CH 210792 A CH210792 A CH 210792A CH 210792D A CH210792D A CH 210792DA CH 210792 A CH210792 A CH 210792A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- sulfamide derivative
- benzene sulfamide
- benzene
- derivative
- Prior art date
Links
Landscapes
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Darstellung eines Benzolsulfamidderivates. Gegenstand des vorliegenden Patentes bildet ein Verfahren zur Darstellung des im Patent Nr. 210781 beschriebenen Benzolsulf- amidderivates,welches dadurch gekennzeich net ist, dass man ein Acylsulfanilsäureamid mit einem 2-Halogen-4,5-dihydro-thiazol um setzt und die erhaltene Verbindung mit hydroli@sierenden Mitteln behandelt.
Die Reaktion wird in An- oder Abwesen heit von indifferenten Lösungsmitteln und zweckmässig in Gegenwart eines Katalysators und/oder säurebindenden Mittels: wie z. B. Kupferpulver, basischen Mitteln z. B. Alka lien wie Pottasche und dergl. vorgenommen.
Beispiel: Eine Mischung von 22 Teilen p-Acet- aminobenzo-Isulfamid, 14 Teilen trockenem Kaliumcarbonat, 17 Teilen 2-Brom-4,5-:di- hydrothiazol und 0,5 Teilen Kupferpulver werden im Ölbad innert 1 Stunde von<B>150'</B> auf 200' erhitzt. Nach dem Erkalten wird die Schmelze in Wasser gelöst, filtriert und durch Zusatz von Säure das 2-(p-Acetamino- benzo-1s.ulfamido)-4,5-dihydro-thiazol gefällt.
Das 2-(p-AminobenzoIsulfamido)-4,5-di- hydro-thiazol kann in üblicher Weise durch saure oder alkalische Verseifung gewonnen werden.
Process for the preparation of a benzenesulfamide derivative. The subject of the present patent is a process for the preparation of the benzenesulfamide derivative described in patent no. 210781, which is characterized in that an acylsulfanilic acid amide is reacted with a 2-halo-4,5-dihydro-thiazole and the compound obtained with treated with hydrolyzing agents.
The reaction is in the presence or absence of inert solvents and conveniently in the presence of a catalyst and / or acid-binding agent: such. B. copper powder, basic agents z. B. Alka lines such as potash and the like. Made.
Example: A mixture of 22 parts of p-acetaminobenzo-isulfamide, 14 parts of dry potassium carbonate, 17 parts of 2-bromo-4,5-: dihydrothiazole and 0.5 part of copper powder are removed from <B> in an oil bath within 1 hour 150 '</B> heated to 200'. After cooling, the melt is dissolved in water, filtered and the 2- (p-acetaminobenzo-1s.ulfamido) -4,5-dihydro-thiazole is precipitated by adding acid.
The 2- (p-aminobenzoisulfamido) -4,5-dihydro-thiazole can be obtained in the usual way by acidic or alkaline saponification.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH210429T | 1938-01-31 | ||
| CH210792T | 1938-01-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH210792A true CH210792A (en) | 1940-07-31 |
Family
ID=25724878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH210792D CH210792A (en) | 1938-01-31 | 1938-01-31 | Process for the preparation of a benzene sulfamide derivative. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH210792A (en) |
-
1938
- 1938-01-31 CH CH210792D patent/CH210792A/en unknown
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