CH168364A - Process for preparing an asymmetric arsenobenzene compound. - Google Patents
Process for preparing an asymmetric arsenobenzene compound.Info
- Publication number
- CH168364A CH168364A CH168364DA CH168364A CH 168364 A CH168364 A CH 168364A CH 168364D A CH168364D A CH 168364DA CH 168364 A CH168364 A CH 168364A
- Authority
- CH
- Switzerland
- Prior art keywords
- acid
- arsenobenzene
- asymmetric
- compound
- preparing
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Darstellung einer asymmetrischen Arsenobenzolverbindung. Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Darstellung einer<I>asym-</I> metrischen Arsenobenzolverbindung, welches dadurch gekennzeichnet ist, dass man 4#Ace- tylainino-2-phenoxyessigsäure-l-arsinsäure zu sammen mit 2-Pyridon-5-arsinsäure reduziert.
Das neue Verfahrensprodukt ist ein gelbes, in Wasser klar und mit neutraler Reaktion lösliches Pulver. Die Lösung hat den Vorzug, haltbar und sowohl bei intravenöser, als auch bei subkutaner, bezw. intramuskulärer In jektion gut wirksam und sehr gut verträg lich zu sein.
<I>Beispiel:</I> 16,7 gr 4-Acetylamino-2-phenogyessigsäu- re-1-arsinsäure und 11 gr 2-Pyridon-5-arsin- säure werden in 800 cm' Wasser heiss ge löst. Zu der<B>65'</B> warmen Lösung gibt man 30 ems 50 % ige unterphosphorige Säure und lcms Jodwasserstoffsäure (Dichte 1,7).
Man hält '/E Stunde auf 60-700, kühlt, saugt den gelben, in Natriumbicarbonat klar lös lichen Niederschlag ab und wäscht mit Wasser aus. Die nutschenfeuchte Substanz wird mit 100 cm3 60 % igem Methylalkohol und etwa 12 em3 3-n-Sodalösung in Lösung gebracht, mit Essigsäure schwach lackmus- sauer gestellt, filtriert und in die 10fache Menge Alkohol und Äther eingerührt. Der Niederschlag wird abgesaugt und mit Alko hol und Äther gewaschen.
Die Substanz ist ein gelbes, in Wasser leicht und klar lös liches Pulver, das beim Erhitzen verkohlt, ohne zu schmelzen. Ausbeute 20 gr.
Process for preparing an asymmetric arsenobenzene compound. The present invention relates to a method for the preparation of an <I> asymmetric </I> metric arsenobenzene compound, which is characterized in that 4 # acetylino-2-phenoxyacetic acid-1-arsic acid is added together with 2-pyridone-5 -arsinic acid reduced.
The new product is a yellow powder that is clear in water and soluble with a neutral reaction. The solution has the advantage of being durable and both intravenous and subcutaneous, respectively. intramuscular injection to be effective and very well tolerated.
<I> Example: </I> 16.7 g of 4-acetylamino-2-phenogyacetic acid-1-arsic acid and 11 g of 2-pyridone-5-arsic acid are dissolved in 800 cm of hot water. 30 ems 50% hypophosphorous acid and 1 cms hydriodic acid (density 1.7) are added to the <B> 65 '</B> warm solution.
The mixture is kept at 60-700 for an hour, cooled, the yellow precipitate which is clear in sodium bicarbonate is filtered off with suction and washed out with water. The moist substance is brought into solution with 100 cm3 of 60% methyl alcohol and about 12 cubic meters of 3N soda solution, made slightly litmus acid with acetic acid, filtered and stirred into 10 times the amount of alcohol and ether. The precipitate is filtered off and washed with alcohol and ether.
The substance is a yellow powder that is easily and clearly soluble in water, which carbonizes when heated without melting. Yield 20 gr.
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE168364X | 1931-12-12 | ||
CH156268T | 1932-12-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH168364A true CH168364A (en) | 1934-03-31 |
Family
ID=25716742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH168364D CH168364A (en) | 1931-12-12 | 1932-12-10 | Process for preparing an asymmetric arsenobenzene compound. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH168364A (en) |
-
1932
- 1932-12-10 CH CH168364D patent/CH168364A/en unknown
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