CH158122A - Process for the preparation of 1-methyl-2-oxyacetic acid benzimidazole-5-arsic acid. - Google Patents

Process for the preparation of 1-methyl-2-oxyacetic acid benzimidazole-5-arsic acid.

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Publication number
CH158122A
CH158122A CH158122DA CH158122A CH 158122 A CH158122 A CH 158122A CH 158122D A CH158122D A CH 158122DA CH 158122 A CH158122 A CH 158122A
Authority
CH
Switzerland
Prior art keywords
acid
methyl
arsic
preparation
benzimidazole
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH158122A publication Critical patent/CH158122A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Description

  

      Verfahren    zur     Darstellung    von     1-Methyl-2-ogyessigsäurebenzimidazol-66-arsinsäure.       Gegenstand der vorliegenden Erfindung  ist ein Verfahren zur Darstellung von     1-          Methyl-2-oxyessigsäurebenzimidazol-    5 -     arsin-          säure,    welches dadurch gekennzeichnet ist,  dass man     1-Methylbenzimidazolon-5-arsin-          säure    mit Halogenessigsäure umsetzt.  



  Das neue Verfahrensprodukt ist aus Was  ser     umkristallisierbar    und hat den Schmelz  punkt<B>308'</B> unter Zersetzung. Es findet als  Heilmittel oder als     Zwischenprodukt    für die  Herstellung von Heilmitteln Verwendung.  



  <I>Beispiel:</I>  90     gr        1-Methyl-benzimidazolon-5-arsin-          säure    werden in 200 cm' Wasser und 83     cm3          Natronlauge    (40       B6)    gelöst und zur Lösung  32     gr    Chloressigsäure gegeben.

   Nach andert  halbstündigem Kochen am     Rüekflusskühler     setzt man     nochmals    32     gr    Chloressigsäure  und 58     cm3    Natronlauge (40       B6)    zu und  kocht eine weitere     Stunde.    Dann wird ab-    gekühlt, mit konzentrierter Salzsäure auf  schwach     eureuma-alkalisch    abgestumpft und  filtriert. Aus dem Filtrat wird mit konzen  trierter Salzsäure die     1-Methyl-2-oxyessig-          säurebenzimidazol-5-arsinsäure    abgeschieden.  Die Säure wird aus Wasser (1 :6) um  kristallisiert.

   Ausbeute an umkristallisierter  Säure: 80     gr        Fp.    308   C unter Zersetzung.



      Process for the preparation of 1-methyl-2-ogyacetic acid benzimidazole-66-arsic acid. The present invention relates to a process for the preparation of 1-methyl-2-oxyacetic acid benzimidazole-5-arsic acid, which is characterized in that 1-methylbenzimidazolone-5-arsic acid is reacted with haloacetic acid.



  The new process product can be recrystallized from water and has a melting point <B> 308 '</B> with decomposition. It is used as a remedy or as an intermediate in the manufacture of medicines.



  <I> Example: </I> 90 g of 1-methylbenzimidazolone-5-arsic acid are dissolved in 200 cm 'of water and 83 cm3 of sodium hydroxide solution (40 B6) and 32 g of chloroacetic acid are added to the solution.

   After boiling for one and half hours on the reflux condenser, another 32 grams of chloroacetic acid and 58 cm3 of sodium hydroxide solution (40 B6) are added and the mixture is boiled for another hour. Then it is cooled, blunted with concentrated hydrochloric acid to weakly eureuma-alkaline and filtered. 1-methyl-2-oxyacetic acid benzimidazole-5-arsic acid is separated off from the filtrate with concentrated hydrochloric acid. The acid is crystallized from water (1: 6).

   Yield of recrystallized acid: 80 g. Mp. 308 C with decomposition.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung von 1-Methyl- 2-oxyessigsäurebenzimidazol-5-arsinsäure, da durch gekennzeichnet, dass man 1-Methyl- benzimidazolon-5-arsinsäure mit Halogen essigsäure umsetzt. Das neue Verfahrensprodukt ist aus Was ser umkristallisierbar und hat den Schmelz punkt 308 unter Zersetzung. Es findet als Heilmittel oder als Zwischenprodukt für die Herstellung von Heilmitteln Verwendung. UNTERANSPRÜCHE: 1. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man die Umsetzung in wässeriger Lösung unter Erhitzen aus führt. PATENT CLAIM: Process for the preparation of 1-methyl-2-oxyacetic acid benzimidazole-5-arsic acid, characterized in that 1-methyl-benzimidazolone-5-arsic acid is reacted with haloacetic acid. The new process product can be recrystallized from water and has a melting point of 308 with decomposition. It is used as a remedy or as an intermediate in the manufacture of medicines. SUBClaims: 1. The method according to claim, characterized in that the reaction is carried out in an aqueous solution with heating. Verfahren nach Patentanspruch, dadurch g e 'kennzeichnet, dass man zur Umsetzung Chloressigsäure verwendet. Process according to patent claim, characterized in that chloroacetic acid is used for the reaction.
CH158122D 1930-07-22 1931-07-14 Process for the preparation of 1-methyl-2-oxyacetic acid benzimidazole-5-arsic acid. CH158122A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE158122X 1930-07-22
CH155449T 1931-07-14

Publications (1)

Publication Number Publication Date
CH158122A true CH158122A (en) 1932-10-31

Family

ID=25716577

Family Applications (1)

Application Number Title Priority Date Filing Date
CH158122D CH158122A (en) 1930-07-22 1931-07-14 Process for the preparation of 1-methyl-2-oxyacetic acid benzimidazole-5-arsic acid.

Country Status (1)

Country Link
CH (1) CH158122A (en)

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