CH131960A - Process for the preparation of 1-amino-3-dimethylamino-2-propanol. - Google Patents

Process for the preparation of 1-amino-3-dimethylamino-2-propanol.

Info

Publication number
CH131960A
CH131960A CH131960DA CH131960A CH 131960 A CH131960 A CH 131960A CH 131960D A CH131960D A CH 131960DA CH 131960 A CH131960 A CH 131960A
Authority
CH
Switzerland
Prior art keywords
amino
propanol
dimethylamino
preparation
dimethylamine
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH131960A publication Critical patent/CH131960A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

       

      Yerfahreu    zur     Darstellung    von     1-Amino-3-dimethslamino-2-propanol.       Es wurde gefunden, dass man das bisher  nicht bekannte     1-Amino-3-dimethylamino-2-          propanol    gewinnen kann, wenn man auf       3-Halogen        -2-oxypi-opylplitalimid        Dimethyl-          amin    einwirken lässt und aus dem erhaltenen  Produkt den     Phtalsäurerest    abspaltet.  



       Beispiel:     130     gr        3-Chlor-2-ogypropylpbtalimid        wer-          den        mit        175        gr        einer        30        %igen        alkoholischen          Dimethylaminlösung    4 Stunden lang in der  Dampfbombe erhitzt.

   Der Bombeninhalt wird  darauf eingedampft,     derzurückbleibende        Syrup     4     Stunden        mit        750        cm'        20%iger        Salzsäure     gekocht, die Lösung nach dem Erkalten von  der     Phtalsäure    getrennt und im Vakuum bis  zur     Syrupdicke    eingeengt. Der     Syrup    wird  mit konzentrierter Natronlauge und darauf  mit Pottasche bis zur Bildung eines dicken  Breis versetzt, der wiederholt mit Benzol     di-          geriert    wird.

   Die     Benzolauszüge    werden nach  dem Trocknen mit     Kaliumkarbonat    vom Ben-         zol    befreit und der     Rückstand    im Vakuum  destilliert.  



  Die neue Base siedet unter 28 mm Druck  bei 103 0. Sie bildet ein basisch riechendes,  farbloses Öl und gibt ein festes, jedoch äusserst  hygroskopisches Chlorhydrat.



      Yerfahreu for the preparation of 1-amino-3-dimethslamino-2-propanol. It has been found that the previously unknown 1-amino-3-dimethylamino-2-propanol can be obtained if dimethylamine is allowed to act on 3-halo -2-oxypi-opylplitalimide and the phthalic acid residue is split off from the product obtained.



       Example: 130 grams of 3-chloro-2-ogypropyl pbtalimide are heated in a steam bomb for 4 hours with 175 grams of a 30% alcoholic dimethylamine solution.

   The contents of the bomb are then evaporated, the remaining syrup is boiled for 4 hours with 750 cm 'of 20% hydrochloric acid, the solution is separated from the phthalic acid after cooling and concentrated in vacuo to the syrup thickness. Concentrated sodium hydroxide solution and then potash are added to the syrup until a thick paste forms, which is repeatedly digested with benzene.

   After drying with potassium carbonate, the benzene extracts are freed from benzene and the residue is distilled in vacuo.



  The new base boils at 103 0 under 28 mm pressure. It forms a colorless oil with a basic odor and gives a solid, but extremely hygroscopic hydrochloride.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung von 1-Amino- 3-dimethylamino-2-propanol dadurch gekenn zeichnet, dass man 3-Halogen-2-oxypropyl- phtalimid mit Dimethylamin umsetzt und den Phtalsäurerest abspaltet. Das 1-Amino-3-dimethylamino-2-propanol ist ein basisch riechendes farbloses Öl vom Siedepunkt 103 0 bei 28 mm Druck und gibt ein festes hygroskopisches Chlorhydrat. PATENT CLAIM: Process for the preparation of 1-amino-3-dimethylamino-2-propanol characterized in that 3-halo-2-oxypropyl-phthalimide is reacted with dimethylamine and the phthalic acid residue is split off. 1-Amino-3-dimethylamino-2-propanol is a basic-smelling colorless oil with a boiling point of 103 ° at 28 mm pressure and gives a solid, hygroscopic chlorohydrate.
CH131960D 1926-08-13 1927-08-11 Process for the preparation of 1-amino-3-dimethylamino-2-propanol. CH131960A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE131960X 1926-08-13
CH130697T 1927-08-11

Publications (1)

Publication Number Publication Date
CH131960A true CH131960A (en) 1929-03-15

Family

ID=25711486

Family Applications (1)

Application Number Title Priority Date Filing Date
CH131960D CH131960A (en) 1926-08-13 1927-08-11 Process for the preparation of 1-amino-3-dimethylamino-2-propanol.

Country Status (1)

Country Link
CH (1) CH131960A (en)

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