CH161749A - Process for the preparation of 2-dicyclohexylaminoethylaminopyridine. - Google Patents

Process for the preparation of 2-dicyclohexylaminoethylaminopyridine.

Info

Publication number
CH161749A
CH161749A CH161749DA CH161749A CH 161749 A CH161749 A CH 161749A CH 161749D A CH161749D A CH 161749DA CH 161749 A CH161749 A CH 161749A
Authority
CH
Switzerland
Prior art keywords
preparation
dicyclohexylaminoethylaminopyridine
dibromohydrate
aminopyridine
melting point
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH161749A publication Critical patent/CH161749A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Description

  

  Verfahren zur Darstellung von     2-Dieyeloheaylaminoäthylaminopyridin.       Gegenstand der vorliegenden Erfindung  ist ein Verfahren zur Darstellung von     2-Di-          cyelohexylaminoäthylaminopyridin,    welches  darin besteht, dass man     Chloräthyldicyclo-          hexylamin    mit der     Natriumverbindung    des       2-Aminopyridins    umsetzt.  



  Die neue Verbindung ist als Heilmittel  verwendbar und siedet unter 2 mm Druck  bei     190-r95     ; sie bildet ein     Dibromhydrat     vom Schmelzpunkt 198   C.  



  <I>Beispiel:</I>  20 Gewichtsteile     2-Aminopyridin,    200 Ge  wichtsteile     Toluol    und 8 Gewichtsteile     Na-          triumamid    werden unter Rühren     11/2    Stunden  auf dem Dampfbad erwärmt. Danach gibt  man 36 Gewichtsteile     Ohloräthyldicyclohexyl-          amin    hinzu und erhitzt weiter eine Stunde  auf dem Dampfbad. Nach dem Erkalten ver  setzt man mit Wasser, trennt das     Toluol    ab  und reinigt die neue Base:  
EMI0001.0018     
    nach dem Trocknen und     Abdestillieren    des       Toluols    im Vakuum.

   Sie siedet bei 2 mm  Druck bei 190-195   und liefert ein     Dibrom-          hydrat    vom Schmelzpunkt<B>1980</B> C.



  Process for the preparation of 2-Dieyeloheaylaminoäthylaminopyridin. The present invention relates to a process for the preparation of 2-dicyelohexylaminoethylaminopyridine, which consists in reacting chloroethyldicyclohexylamine with the sodium compound of 2-aminopyridine.



  The new compound is useful as a remedy and boils under 2mm pressure at 190-r95; it forms a dibromohydrate with a melting point of 198 C.



  <I> Example: </I> 20 parts by weight of 2-aminopyridine, 200 parts by weight of toluene and 8 parts by weight of sodium amide are heated for 11/2 hours on the steam bath while stirring. Then 36 parts by weight of chloroethyldicyclohexylamine are added and the mixture is heated on the steam bath for a further hour. After cooling down, water is added, the toluene is separated off and the new base is purified:
EMI0001.0018
    after drying and distilling off the toluene in vacuo.

   It boils at 190-195 at 2 mm pressure and yields a dibromohydrate with a melting point of <B> 1980 </B> C.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung von 2-Dicyclo- hexylaminoäthylaminopyridin, dadurch ge kennzeichnet, dass man Ohloräthyldicyolo- hexylamin mit der Natriumverbindung des 2-Aminopyridins umsetzt. Die neue Verbindung ist als Heilmittel verwendbar und siedet unter 2 mm Druck bei 190-195" C; sie bildet ein Dibrom- hydrat vom Schmelzpunkt<B>1980</B> C. PATENT CLAIM: Process for the preparation of 2-dicyclohexylaminoethylaminopyridine, characterized in that Ohloräthyldicyolo- hexylamine is reacted with the sodium compound of 2-aminopyridine. The new compound can be used as a remedy and boils under 2 mm pressure at 190-195 "C; it forms a dibromohydrate with a melting point of <B> 1980 </B> C. UNTERANSPRUCI3 Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man die Umsetzung durch Erwärmen auf dem Dampfbad aus führt. SUBSTITUTE SHEET A method according to claim, characterized in that the reaction is carried out by heating on the steam bath.
CH161749D 1932-07-15 1932-07-15 Process for the preparation of 2-dicyclohexylaminoethylaminopyridine. CH161749A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH158827T 1932-07-15
CH161749T 1932-07-15

Publications (1)

Publication Number Publication Date
CH161749A true CH161749A (en) 1933-05-15

Family

ID=25717152

Family Applications (1)

Application Number Title Priority Date Filing Date
CH161749D CH161749A (en) 1932-07-15 1932-07-15 Process for the preparation of 2-dicyclohexylaminoethylaminopyridine.

Country Status (1)

Country Link
CH (1) CH161749A (en)

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