CH122536A - Process for the preparation of a pyridine substitution product. - Google Patents
Process for the preparation of a pyridine substitution product.Info
- Publication number
- CH122536A CH122536A CH122536DA CH122536A CH 122536 A CH122536 A CH 122536A CH 122536D A CH122536D A CH 122536DA CH 122536 A CH122536 A CH 122536A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- oxy
- substitution product
- pyridine substitution
- pyridine
- Prior art date
Links
Landscapes
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Description
Verfahren zur Darstellung eines Pyridinsubstitutionsproduktes. Durch das Hauptpatent ist ein Verfahren zur Herstellung von 2-Oxy-5-jodpyridin ge schützt, welches dadurch gekennzeichnet ist, dass 2-Oxy-5-aminopyridin dianotiert und hier auf jodiert wird. Nach dem Verfahren gemäss der vorliegenden Erfindung wird die Jodie- rung dadurch ausgeführt, dass 2-Oxy-5-amino- pyridin in Gegenwart von jodliefernden Stoffen, z.
B. Alkalijodiden, Kupferjodür, Nickeljodür und dergleichen in saurer Lösung mit Alkali nitrit versetzt wird. Das Verfahren kann in Gegenwart von Katalysatoren, zum Bei spiel von Kupfer durchgeführt werden.
Beispiel: 100 gr salzsaures 2-Oxy-5-aminopyridin werden in 200 gr konzentrierter Salzsäure gelöst und die Lösung mit 300 cm' Wasser verdünnt. Hierauf werden 350 gr Kalium jodid in 350 cm' Wasser gelöst zugesetzt. In das erhaltene Gemisch lässt man alsdann eine Lösung von 47 gr Natriumnitrit in 200 cm3 Wasser einfliessen, wobei sowohl in der Kälte, wie auch in der Wärme gearbeitet werden kann.
Nach Beendigung der Reaktion erwärmt man noch einige Zeit auf dem Wasser bad, worauf man das Reaktionsprodukt meh- rere Stunden stehen lässt. Das pulverförmig abgeschiedene 2-Oxy-5-jodpyridin wird alsdann zweckmässig über das Natriumsalz gereinigt, zum Beispiel derart, dass es durch Behandeln mit Natronlauge in das Natriumsalz überge führt und das letztere durch Umkristallisieren in Wasser in reiner Form gewonnen wird. Durch Behandeln des gereinigten Salzes mit Säuren, zum Beispiel durch Einleiten von Kohlensäure in die wässerige Lösung erhält man das freie 2-Oxy-5-jodpyridin in reiner Form. Schmelzpunkt 191-192
Process for the preparation of a pyridine substitution product. The main patent protects a process for the production of 2-oxy-5-iodopyridine, which is characterized in that 2-oxy-5-aminopyridine is dianotized and is iodized here. According to the process according to the present invention, the iodination is carried out in that 2-oxy-5-aminopyridine in the presence of iodine-supplying substances, e.g.
B. alkali iodides, copper iodine, nickel iodine and the like in acidic solution with alkali nitrite. The process can be carried out in the presence of catalysts, for example copper.
Example: 100 grams of hydrochloric acid 2-oxy-5-aminopyridine are dissolved in 200 grams of concentrated hydrochloric acid and the solution is diluted with 300 cm of water. Then 350 grams of potassium iodide dissolved in 350 cm of water are added. A solution of 47 grams of sodium nitrite in 200 cm3 of water is then allowed to flow into the mixture obtained, it being possible to work both in the cold and in the warm.
After the reaction has ended, the mixture is heated on the water bath for some time, after which the reaction product is left to stand for several hours. The 2-oxy-5-iodopyridine deposited in powder form is then conveniently purified using the sodium salt, for example in such a way that it is converted into the sodium salt by treatment with sodium hydroxide solution and the latter is obtained in pure form by recrystallization in water. By treating the purified salt with acids, for example by introducing carbonic acid into the aqueous solution, the free 2-oxy-5-iodopyridine is obtained in pure form. Mp 191-192
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE122536X | 1925-05-28 | ||
| CH117895T | 1925-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH122536A true CH122536A (en) | 1927-09-16 |
Family
ID=25708899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH122536D CH122536A (en) | 1925-05-28 | 1926-05-11 | Process for the preparation of a pyridine substitution product. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH122536A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2459360A (en) * | 1945-04-03 | 1949-01-18 | Wyeth Corp | Lactone derivatives of 2-pyridone compounds |
-
1926
- 1926-05-11 CH CH122536D patent/CH122536A/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2459360A (en) * | 1945-04-03 | 1949-01-18 | Wyeth Corp | Lactone derivatives of 2-pyridone compounds |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE477386C (en) | Generation of calcium hypochlorite | |
| CH122536A (en) | Process for the preparation of a pyridine substitution product. | |
| AT119474B (en) | Process for the preparation of substitution products of ß-iodopyridine. | |
| AT165079B (en) | Process for the production of trimethyl (beta-iodoethyl) ammonium iodide | |
| DE337939C (en) | Process for the production of a betaine of hexamethylenetetramine | |
| DE622308C (en) | Process for the preparation of o-aminonaphthalenecarboxylic acids | |
| AT117475B (en) | Process for the preparation of substitution products of ß-iodopyridine. | |
| DE413380C (en) | Process for the preparation of pure 1-nitro-2-methylanthraquinone | |
| DE555085C (en) | Process for the preparation of 2-amino-3-oxynaphthalene | |
| DE920668C (en) | Process for the manufacture of a herbicide in a stable, highly concentrated form | |
| DE627481C (en) | Process for the production of glyoxylic acid | |
| AT103630B (en) | Process for the production of double carbonates of sodium with magnesium. | |
| AT131132B (en) | Process for the preparation of 2-oxyacetic acid benzimidazolar acids. | |
| AT151014B (en) | Process for the production of phthalic acid bis [diethylamide]. | |
| AT91239B (en) | Method for the representation of fights from Bornychloride. | |
| DE631570C (en) | Process for the production of selenium-containing organic compounds | |
| DE239953C (en) | ||
| AT112127B (en) | Process for the preparation of halogenated pyridine derivatives. | |
| CH129173A (en) | Process for the preparation of 2-amino-5-iodopyridine. | |
| CH163784A (en) | Process for the preparation of a neutrally soluble metal complex salt. | |
| CH155447A (en) | Process for the preparation of 4-oxypyridine. | |
| CH165722A (en) | Process for the preparation of a neutrally soluble metal complex salt. | |
| CH207304A (en) | Process for the production of a stable, water-soluble substance suitable as a cleaning, emulsifying and wetting agent. | |
| CH161753A (en) | Process for the preparation of 2-amino-3-oxy-4-methoxybenzene-1-arsic acid. | |
| CH155449A (en) | Process for the preparation of 2-oxyacetic acid benzimidazole-5-arsic acid. |