CA999578A - 14-hydroxymorphinan derivatives - Google Patents

14-hydroxymorphinan derivatives

Info

Publication number
CA999578A
CA999578A CA150,036A CA150036A CA999578A CA 999578 A CA999578 A CA 999578A CA 150036 A CA150036 A CA 150036A CA 999578 A CA999578 A CA 999578A
Authority
CA
Canada
Prior art keywords
hydroxymorphinan derivatives
hydroxymorphinan
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA150,036A
Other languages
English (en)
Other versions
CA150036S (en
Inventor
Irwin J. Pachter
Bernard R. Belleau
Ivo Monkovic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Canada Inc
Original Assignee
Bristol Myers Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Canada Ltd filed Critical Bristol Myers Canada Ltd
Application granted granted Critical
Publication of CA999578A publication Critical patent/CA999578A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA150,036A 1971-09-08 1972-08-23 14-hydroxymorphinan derivatives Expired CA999578A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17883771A 1971-09-08 1971-09-08
US00217633A US3819635A (en) 1971-09-08 1972-01-13 14-hydroxymorphinan derivatives

Publications (1)

Publication Number Publication Date
CA999578A true CA999578A (en) 1976-11-09

Family

ID=26874723

Family Applications (1)

Application Number Title Priority Date Filing Date
CA150,036A Expired CA999578A (en) 1971-09-08 1972-08-23 14-hydroxymorphinan derivatives

Country Status (19)

Country Link
US (1) US3819635A (pl)
JP (1) JPS5310596B2 (pl)
AU (1) AU470102B2 (pl)
BE (1) BE788478A (pl)
CA (1) CA999578A (pl)
CH (1) CH590845A5 (pl)
CY (1) CY980A (pl)
DD (1) DD100255A5 (pl)
DE (3) DE2265255C2 (pl)
DK (1) DK141624B (pl)
FR (1) FR2154481B1 (pl)
GB (2) GB1412129A (pl)
HK (1) HK2679A (pl)
IE (2) IE36687B1 (pl)
KE (1) KE2911A (pl)
MY (1) MY7900027A (pl)
NL (1) NL162072C (pl)
SE (2) SE398877B (pl)
YU (1) YU45099B (pl)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910920A (en) * 1973-11-07 1975-10-07 Bristol Myers Co 3,14,17-Substituted-6,7-tetramethylenemorphinans
US3980641A (en) * 1975-07-31 1976-09-14 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinans
US4017497A (en) * 1975-11-18 1977-04-12 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
US4139534A (en) * 1977-02-17 1979-02-13 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
US4058531A (en) * 1976-03-23 1977-11-15 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
US4052389A (en) * 1976-03-23 1977-10-04 Bristol-Myers Company Derivatives of 9,10-dihydroxy-1-(p-alkoxybenzyl)-perhydroisoquinoline oxazine-3-one
JPS52136176A (en) * 1976-03-23 1977-11-14 Bristol Myers Co Method of improving 144hydroxymorphinan derivatives
GB1593191A (en) * 1977-03-23 1981-07-15 Reckitt & Colmann Prod Ltd Derivatives of morphine
GB1587831A (en) * 1977-03-23 1981-04-08 Reckitt & Colmann Prod Ltd Morphine derivatives
US4115389A (en) * 1977-05-02 1978-09-19 Bristol-Myers Company Process of N-demethylating (-)-1-(p-methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline
US4338320A (en) * 1978-11-15 1982-07-06 The Board Of Regents Of The University Of Nebraska Esters of 6'-hydroxycinchonine, and a method of treating arrythmia with them
US4228285A (en) * 1979-02-28 1980-10-14 Bristol-Myers Company 14-Hydroxy-6-oxamorphinans and 14-hydroxy-6-oxaisomorphinans
US4272540A (en) * 1979-04-24 1981-06-09 Sisa, Incorporated 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
US4322427A (en) * 1981-04-16 1982-03-30 Bristol-Myers Company Analgetic compositions and methods of use
DE69414085T2 (de) * 1993-07-19 1999-03-18 Toray Industries, Inc., Tokio/Tokyo Wirkstoff zum schutze von gehirnzellen
WO1995003308A1 (en) * 1993-07-23 1995-02-02 Toray Industries, Inc. Morphinan derivative and medicinal use
CZ281174B6 (cs) * 1993-08-13 1996-07-17 Galena, A.S. Způsob přípravy 3,14ß-dihydroxy-17-normorfinanu
CA2321924A1 (en) 1998-02-25 1999-09-02 Abbott Laboratories Butorphanol sustained release formulations
US20040167164A1 (en) * 1998-05-05 2004-08-26 Jose Pozuelo Compositions and methods for treating particular chemical addictions and mental illnesses
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7501433B2 (en) * 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
EP1506174B1 (en) 2002-05-17 2015-09-30 Taiwanj Pharmaceuticals Co., Ltd. Use of naltrexone for treating kidney and liver damage
US8017622B2 (en) * 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
CN103073496B (zh) * 2013-02-18 2015-08-26 苏州立新制药有限公司 右美沙芬的制备方法
JP6464181B2 (ja) 2014-10-14 2019-02-06 久光製薬株式会社 貼付剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3166559A (en) * 1965-01-19 J-lower alkoxy-x-phenyloxy-ix-hydroxy-
GB1028407A (en) * 1962-04-06 1966-05-04 Shionogi & Co Improvements in or relating to morphinan derivatives and their preparation
FR1362540A (fr) * 1963-04-05 1964-06-05 Shionogi & Co Dérivés n substitués du morphinane et leur production

Also Published As

Publication number Publication date
DD100255A5 (pl) 1973-09-12
JPS4834864A (pl) 1973-05-22
SE403286B (sv) 1978-08-07
IE36688B1 (en) 1977-02-02
DE2265255A1 (de) 1977-01-27
DE2243961A1 (de) 1973-04-05
IE36687B1 (en) 1977-02-02
GB1412130A (en) 1975-10-29
JPS5310596B2 (pl) 1978-04-14
IE36687L (en) 1973-03-08
DE2265255C2 (de) 1986-06-05
YU45099B (sh) 1992-07-20
MY7900027A (en) 1979-12-31
AU470102B2 (en) 1976-03-04
FR2154481A1 (pl) 1973-05-11
CH590845A5 (pl) 1977-08-31
CY980A (en) 1979-03-23
GB1412129A (en) 1975-10-29
NL162072C (nl) 1980-04-15
DE2243961C2 (pl) 1988-07-21
DE2265256A1 (de) 1977-01-27
NL7212176A (pl) 1973-03-12
SE398877B (sv) 1978-01-23
BE788478A (fr) 1973-03-06
KE2911A (en) 1979-01-26
DK141624B (da) 1980-05-12
DK141624C (pl) 1980-10-13
DE2265256C2 (de) 1985-10-24
NL162072B (nl) 1979-11-15
US3819635A (en) 1974-06-25
YU227772A (en) 1982-02-28
SE7506292L (sv) 1975-06-02
FR2154481B1 (pl) 1976-04-23
AU4622872A (en) 1974-03-07
HK2679A (en) 1979-01-19

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