CA945161A - 2,5-disubstituted imidazoles and methods of preparing same - Google Patents

2,5-disubstituted imidazoles and methods of preparing same

Info

Publication number
CA945161A
CA945161A CA099,661A CA99661A CA945161A CA 945161 A CA945161 A CA 945161A CA 99661 A CA99661 A CA 99661A CA 945161 A CA945161 A CA 945161A
Authority
CA
Canada
Prior art keywords
methods
preparing same
disubstituted imidazoles
imidazoles
disubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA099,661A
Other languages
English (en)
Other versions
CA99661S (en
Inventor
John J. Baldwin
Frederick C. Novello
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of CA945161A publication Critical patent/CA945161A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/93—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by halogen atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/95—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by nitrogen atoms, attached to other ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA099,661A 1969-12-15 1970-12-02 2,5-disubstituted imidazoles and methods of preparing same Expired CA945161A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US88536269A 1969-12-15 1969-12-15
US26501572A 1972-06-21 1972-06-21
US00265016A US3818014A (en) 1969-12-15 1972-06-21 2-quinolyl-4(5)-trifluoromethylimidazoles
US45610274A 1974-03-29 1974-03-29
US61090375A 1975-09-05 1975-09-05
US05/610,904 US4032522A (en) 1969-12-15 1975-09-05 2-pyrazinyl-trifluoromethylimidazoles and a method for their preparation

Publications (1)

Publication Number Publication Date
CA945161A true CA945161A (en) 1974-04-09

Family

ID=27559450

Family Applications (1)

Application Number Title Priority Date Filing Date
CA099,661A Expired CA945161A (en) 1969-12-15 1970-12-02 2,5-disubstituted imidazoles and methods of preparing same

Country Status (10)

Country Link
US (4) US3786061A (de)
AT (1) AT300788B (de)
BE (1) BE760289A (de)
CA (1) CA945161A (de)
CH (1) CH566994A5 (de)
DE (2) DE2061515A1 (de)
FR (1) FR2081360B1 (de)
GB (1) GB1301754A (de)
NL (1) NL7017486A (de)
SE (1) SE388855B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7017486A (de) * 1969-12-15 1971-06-17
US3707475A (en) * 1970-11-16 1972-12-26 Pfizer Antiinflammatory imidazoles
GB1481512A (en) * 1973-07-12 1977-08-03 Lucas Electrical Ltd Radiation-sensitive switching circuits
US4058614A (en) * 1973-12-04 1977-11-15 Merck & Co., Inc. Substituted imidazole compounds and therapeutic compositions therewith
DE2414280C2 (de) * 1974-03-25 1981-12-17 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von 1-Methyl-5-nitroimidazolen
US4134983A (en) * 1975-03-03 1979-01-16 Merck & Co., Inc. 3-amino-2-or-propoxyaryl substituted imidazoles
US4853383A (en) * 1975-03-03 1989-08-01 Merck & Co., Inc. β-blocking substituted imidazoles
US4199580A (en) * 1975-03-03 1980-04-22 Merck & Co., Inc. 3-Amino-2-or-propoxy-tetrahydronaphthyl or indanyl-substituted imidazoles and use
US4179512A (en) * 1977-03-01 1979-12-18 Merck & Co., Inc. 4-Substituted-2-arylimidazoles
US4314844A (en) * 1979-01-11 1982-02-09 Rohm And Haas Company Herbicidal substituted imidazoles
US4281005A (en) * 1979-03-05 1981-07-28 Merck & Co., Inc. Novel 2-pyridylimidazole compounds
IL62794A0 (en) * 1980-06-02 1981-07-31 American Cyanamid Co Substituted nicotinic acid esters and salts thereof and their use as herbicidal agents
DE3121736C2 (de) * 1980-06-02 1994-04-07 American Cyanamid Co 2-(2-Imidazolin-2-yl)-pyridine und -chinoline, Verfahren und Zwischenstufen zur Herstellung derselben und Verwendung derselben als herbizide Wirkstoffe
US4315021A (en) * 1980-12-03 1982-02-09 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles
US4499097A (en) * 1983-03-10 1985-02-12 American Cyanamid Company 2-(Pyridyl)imidazolyl ketones
US4602093A (en) * 1984-02-08 1986-07-22 Merck & Co., Inc. Novel substituted imidazoles, their preparation and use
FR2576308B1 (fr) * 1985-01-18 1987-02-20 Synthelabo Derives de tetrahydroquinoleine, leur preparation et leur application en therapeutique
GB8705183D0 (en) * 1987-03-05 1987-04-08 May & Baker Ltd Compositions of matter
US4914207A (en) * 1989-05-09 1990-04-03 Pfizer Inc. Arylthiazolylimidazoles
FR2649999B1 (fr) * 1989-07-21 1991-09-20 Payen Cie L Procede et machine pour la fabrication en continu d'un fil elastique a base d'elasthane
US5189053A (en) * 1989-08-10 1993-02-23 Schering Agrochemicals Limited Imidazol(in)e substituted haloarylpyrazole pesticides
YU47834B (sr) * 1989-08-10 1996-01-09 Schering Agrochemical Limited Azolni pesticid
JP3393891B2 (ja) * 1992-08-18 2003-04-07 塩野義製薬株式会社 イミダゾール類の製造方法
WO1995033730A1 (fr) * 1994-06-09 1995-12-14 Nippon Soda Co., Ltd. Derive d'imidazole, procede de production et herbicide
GB2344588B (en) * 1997-07-25 2001-11-14 Black James Foundation 1H-4(5)-substituted imidazole derivatives their preparation and their use as histamine H 3 receptor ligands
GB9715814D0 (en) 1997-07-25 1997-10-01 Black James Foundation Histamine H3 receptor ligands
AU1520699A (en) 1997-11-07 1999-05-31 Johns Hopkins University, The Methods for treatment of disorders of cardiac contractility
WO2000018763A2 (en) * 1998-09-29 2000-04-06 Neurogen Corporation 2-(2,3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands
US6288230B1 (en) 1998-09-29 2001-09-11 Neurogen Corporation 2-(2, 3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands
US6284759B1 (en) 1998-09-30 2001-09-04 Neurogen Corporation 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands
AU2001268734A1 (en) * 2000-06-28 2002-01-08 Merck & Co., Inc. Use of agents capable of reducing uric acid levels for the treatment of cardiovascular disease
ATE529110T1 (de) * 2002-03-05 2011-11-15 Transtech Pharma Inc Mono- und bicyclische azolderivate die die interaktion von liganden mit rage hemmen
MXPA05012350A (es) * 2003-05-20 2006-05-25 Transtech Pharma Inc Antagonistas rage como agentes para la amiloidosis inversa y enfermedades asociadas con la misma.
KR20080066938A (ko) * 2005-10-07 2008-07-17 깃세이 야쿠힌 고교 가부시키가이샤 질소 함유 복소환 화합물 및 그것을 함유하는 의약 조성물
US8580833B2 (en) 2009-09-30 2013-11-12 Transtech Pharma, Inc. Substituted imidazole derivatives and methods of use thereof
HU1000676D0 (en) * 2010-12-17 2011-02-28 Pharmahungary 2000 Kft Inhibitors of matrix metalloproteinase, pharmaceutical compositions thereof and use of them for preventing and treating diseases where the activation of mmp is involved
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3202674A (en) * 1960-03-05 1965-08-24 American Home Prod Phenethylamine derivatives
US3399211A (en) * 1964-03-10 1968-08-27 Merck & Co Inc Production of 2-aryl-4(5)-nitroimidazoles
NL6816241A (de) * 1967-12-01 1969-06-03
US3652579A (en) * 1969-06-26 1972-03-28 Hoffmann La Roche 1-methyl-2-substituted 5-nitroimidazoles
NL7017486A (de) * 1969-12-15 1971-06-17
US3691178A (en) * 1970-03-16 1972-09-12 Merck & Co Inc Substituted imidazoles

Also Published As

Publication number Publication date
BE760289A (fr) 1971-06-14
DE2061489A1 (de) 1971-07-29
US3818014A (en) 1974-06-18
FR2081360A1 (de) 1971-12-03
US3786061A (en) 1974-01-15
AT300788B (de) 1972-08-10
CH566994A5 (de) 1975-09-30
DE2061515A1 (de) 1971-06-24
DE2061489C2 (de) 1982-04-01
SE388855B (sv) 1976-10-18
US4032522A (en) 1977-06-28
NL7017486A (de) 1971-06-17
GB1301754A (de) 1973-01-04
FR2081360B1 (de) 1974-08-23
US4125530A (en) 1978-11-14

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