CA921904A - Process of preparing 1-glycosyl-5-azacytosines - Google Patents

Process of preparing 1-glycosyl-5-azacytosines

Info

Publication number
CA921904A
CA921904A CA050902A CA50902A CA921904A CA 921904 A CA921904 A CA 921904A CA 050902 A CA050902 A CA 050902A CA 50902 A CA50902 A CA 50902A CA 921904 A CA921904 A CA 921904A
Authority
CA
Canada
Prior art keywords
azacytosines
glycosyl
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA050902A
Other languages
English (en)
Other versions
CA50902S (en
Inventor
Piskala Alois
Sorm Frantisek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Czech Academy of Sciences CAS
Original Assignee
Czech Academy of Sciences CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Czech Academy of Sciences CAS filed Critical Czech Academy of Sciences CAS
Application granted granted Critical
Publication of CA921904A publication Critical patent/CA921904A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA050902A 1968-05-08 1969-05-08 Process of preparing 1-glycosyl-5-azacytosines Expired CA921904A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS339968 1968-05-08

Publications (1)

Publication Number Publication Date
CA921904A true CA921904A (en) 1973-02-27

Family

ID=5373920

Family Applications (1)

Application Number Title Priority Date Filing Date
CA050902A Expired CA921904A (en) 1968-05-08 1969-05-08 Process of preparing 1-glycosyl-5-azacytosines

Country Status (12)

Country Link
JP (1) JPS4916435B1 (ja)
AT (1) AT306930B (ja)
BE (1) BE732268A (ja)
BR (1) BR6908600D0 (ja)
CA (1) CA921904A (ja)
CH (1) CH527207A (ja)
DE (1) DE1922702A1 (ja)
ES (1) ES366910A1 (ja)
FR (1) FR2008048A1 (ja)
GB (1) GB1227691A (ja)
IT (1) IT1037009B (ja)
NL (1) NL6906909A (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2012888C3 (de) * 1970-03-14 1981-04-02 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden
US6905669B2 (en) 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
US6982253B2 (en) 2002-06-05 2006-01-03 Supergen, Inc. Liquid formulation of decitabine and use of the same
US6887855B2 (en) * 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US6943249B2 (en) 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
US7038038B2 (en) 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
US20060014949A1 (en) * 2004-07-13 2006-01-19 Supergen Inc. Compositions and formulations of decitabine polymorphs and methods of use thereof
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
ES2969144T3 (es) 2008-05-15 2024-05-16 Celgene Corp Formulaciones orales de análogos de citidina y métodos de uso de los mismos
WO2010017547A1 (en) 2008-08-08 2010-02-11 Scinopharm Taiwan Ldt. Process for making 5-azacytosine nucleosides and their derivatives
JP6289361B2 (ja) 2011-03-31 2018-03-07 セルジーン インターナショナル サルル ５−アザシチジンの合成
EP2750768B1 (en) 2011-08-30 2018-10-03 Astex Pharmaceuticals, Inc. Decitabine derivative formulations
JP6768722B2 (ja) 2015-07-02 2020-10-14 大塚製薬株式会社 凍結乾燥医薬組成物
WO2017090264A1 (ja) 2015-11-27 2017-06-01 大原薬品工業株式会社 ５－アザシチジン又は其の２'－デオキシ体の５'位ジベンジル燐酸エステル
JP6162349B1 (ja) 2016-04-21 2017-07-12 大原薬品工業株式会社 ５−アザシチジン類の糖部シリルエーテル誘導体
WO2017183215A1 (ja) 2016-04-21 2017-10-26 大原薬品工業株式会社 ５－アザシチジン類の糖部シリルエーテル誘導体
US10227374B2 (en) 2016-04-21 2019-03-12 Ohara Pharmaceutical Co., Ltd. Silyl etherified derivatives of 5-azacytidines in carbohydrate moiety
AU2018310857A1 (en) 2017-08-03 2020-02-13 Otsuka Pharmaceutical Co., Ltd. Drug compound and purification methods thereof

Also Published As

Publication number Publication date
GB1227691A (ja) 1971-04-07
NL6906909A (ja) 1969-11-11
FR2008048A1 (ja) 1970-01-16
BR6908600D0 (pt) 1973-02-22
JPS4916435B1 (ja) 1974-04-22
BE732268A (ja) 1969-10-01
AT306930B (de) 1973-04-25
CH527207A (de) 1972-08-31
DE1922702A1 (de) 1969-11-20
IT1037009B (it) 1979-11-10
ES366910A1 (es) 1971-03-16

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