CA3260163A1 - Method of purifying albumin-fusion proteins - Google Patents
Method of purifying albumin-fusion proteinsInfo
- Publication number
- CA3260163A1 CA3260163A1 CA3260163A CA3260163A CA3260163A1 CA 3260163 A1 CA3260163 A1 CA 3260163A1 CA 3260163 A CA3260163 A CA 3260163A CA 3260163 A CA3260163 A CA 3260163A CA 3260163 A1 CA3260163 A1 CA 3260163A1
- Authority
- CA
- Canada
- Prior art keywords
- fusion proteins
- purifying albumin
- albumin
- purifying
- fusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562132198P | 2015-03-12 | 2015-03-12 | |
| US62/132,198 | 2015-03-12 | ||
| CA2977675A CA2977675A1 (en) | 2015-03-12 | 2016-03-11 | Method of purifying albumin-fusion proteins |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2977675A Division CA2977675A1 (en) | 2015-03-12 | 2016-03-11 | Method of purifying albumin-fusion proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3260163A1 true CA3260163A1 (en) | 2026-03-02 |
Family
ID=56878920
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3260163A Pending CA3260163A1 (en) | 2015-03-12 | 2016-03-11 | Method of purifying albumin-fusion proteins |
| CA2977675A Pending CA2977675A1 (en) | 2015-03-12 | 2016-03-11 | Method of purifying albumin-fusion proteins |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2977675A Pending CA2977675A1 (en) | 2015-03-12 | 2016-03-11 | Method of purifying albumin-fusion proteins |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10683340B2 (https=) |
| EP (2) | EP3268389B1 (https=) |
| JP (3) | JP6862348B2 (https=) |
| KR (2) | KR20170124592A (https=) |
| CN (1) | CN107428817B (https=) |
| AU (4) | AU2016228806B2 (https=) |
| CA (2) | CA3260163A1 (https=) |
| ES (1) | ES2839211T3 (https=) |
| IL (1) | IL253971B (https=) |
| WO (1) | WO2016145307A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3753567A1 (en) | 2011-10-11 | 2020-12-23 | Viela Bio, Inc. | Cd40l-specific tn3-derived scaffolds and methods of use thereof |
| ES2991988T3 (es) | 2017-10-30 | 2024-12-05 | Takeda Pharmaceuticals Co | Detergentes compatibles con el medio ambiente para la inactivación de virus con envoltura lipídica |
| EA202092778A1 (ru) | 2018-05-16 | 2021-05-27 | ЛИБ ТЕРАПЬЮТИКС, ЭлЭлСи | Композиции, содержащие pcsk9-связывающие молекулы, и способы применения |
| CN113286806A (zh) * | 2018-11-09 | 2021-08-20 | 尼欧派普制药有限两合公司 | 治疗压力、免疫反应和中风综合征的多肽 |
| EP3711772A1 (en) | 2019-03-20 | 2020-09-23 | Oslo Universitetssykehus HF | Recombinant proteins and fusion proteins |
| CN110295152A (zh) * | 2019-07-29 | 2019-10-01 | 北京泓恩生物科技有限公司 | 一种重组产朊假丝酵母尿酸酶的纯化方法 |
| SG11202110968VA (en) | 2019-12-06 | 2021-10-28 | Regeneron Pharma | Anti-vegf protein compositions and methods for producing the same |
| AU2021268026A1 (en) | 2020-05-08 | 2023-01-19 | Regeneron Pharmaceuticals, Inc. | VEGF traps and mini-traps and methods for treating ocular disorders and cancer |
| JP2023532544A (ja) * | 2020-07-01 | 2023-07-28 | メディミューン，エルエルシー | 生物学的製剤を精製するための洗浄剤及び方法 |
| CN112062833A (zh) * | 2020-10-09 | 2020-12-11 | 国药集团武汉血液制品有限公司 | 一种从血浆组分ⅳ沉淀中提取人血白蛋白的方法 |
| CN115677848A (zh) * | 2022-10-24 | 2023-02-03 | 通化安睿特生物制药股份有限公司 | 一种制备高纯度高稳定性蛋白质的方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| CA2079802C (en) | 1990-04-05 | 2001-09-18 | Roberto Crea | Walk-through mutagenesis |
| US7063943B1 (en) | 1990-07-10 | 2006-06-20 | Cambridge Antibody Technology | Methods for producing members of specific binding pairs |
| US5843701A (en) | 1990-08-02 | 1998-12-01 | Nexstar Pharmaceticals, Inc. | Systematic polypeptide evolution by reverse translation |
| US5866344A (en) | 1991-11-15 | 1999-02-02 | Board Of Regents, The University Of Texas System | Antibody selection methods using cell surface expressed libraries |
| FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| US5440018A (en) * | 1992-05-20 | 1995-08-08 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
| US5922545A (en) | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US6699658B1 (en) | 1996-05-31 | 2004-03-02 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| EP1958962A3 (en) | 1997-06-12 | 2013-05-01 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| NZ511699A (en) | 1998-12-02 | 2003-02-28 | Phylos Inc | DNA-protein fusions and uses thereof |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| DK1196637T3 (da) | 1999-07-27 | 2007-07-30 | Adnexus Therapeutics Inc | Peptidacceptor-ligeringsmetoder |
| US7022479B2 (en) | 2000-01-24 | 2006-04-04 | Compound Therapeutics, Inc. | Sensitive, multiplexed diagnostic assays for protein analysis |
| AU2002310502A1 (en) | 2001-06-21 | 2003-01-08 | Phylos, Inc. | In vitro protein interaction detection systems |
| KR100524872B1 (ko) * | 2003-12-04 | 2005-11-01 | 씨제이 주식회사 | 인터페론 베타의 정제방법 |
| CA2572917C (en) | 2004-07-06 | 2012-04-03 | Bioren Inc. | Look-through mutagenesis for developing altered polypeptides with enhanced properties |
| CN101384623B (zh) | 2005-12-22 | 2013-07-24 | 常山凯捷健生物药物研发（河北）有限公司 | 白蛋白与治疗剂的预成型偶联物的制备方法 |
| KR101610791B1 (ko) | 2007-07-03 | 2016-04-11 | 다누타 크루셰프스카 | 알파케토글루타레이트의 의약 용도 |
| WO2009023184A2 (en) | 2007-08-10 | 2009-02-19 | Protelix, Inc. | Universal fibronectin type iii binding-domain libraries |
| US8633297B2 (en) | 2007-10-31 | 2014-01-21 | Medimmune, Llc | Protein scaffolds |
| ES2705714T3 (es) | 2008-10-31 | 2019-03-26 | Janssen Biotech Inc | Métodos y usos de dominio de Fibronectina tipo III basado en estructuras de composiciones |
| BRPI1008532B1 (pt) | 2009-02-12 | 2021-12-14 | Janssen Biotech, Inc | Arcabouço de proteína isolada, método para construção de uma biblioteca de arcabouço de proteína isolada, molécula de ácido nucleico isolada, vetor de ácido nucleico isolado, célula hospedeira de bactéria ou fungo, composição, dispositivo médico e artigo de manufatura para uso farmacêutico ou de diagnóstico em seres humanos |
| DK2427486T3 (en) | 2009-05-07 | 2015-05-26 | Novozymes Biopharma Dk As | A process for purifying albumin |
| EP2493921B1 (en) | 2009-10-30 | 2018-09-26 | Albumedix Ltd | Albumin variants |
| KR20130020765A (ko) | 2010-02-16 | 2013-02-28 | 메디뮨 엘엘씨 | Ｈｓａ-관련 조성물 및 사용방법 |
| WO2011130324A1 (en) | 2010-04-13 | 2011-10-20 | Medimmune, Llc | Fibronectin type iii domain-based multimeric scaffolds |
| CN103379915A (zh) | 2011-02-15 | 2013-10-30 | 米迪缪尼有限公司 | Hsa相关组合物及使用方法 |
| EP3753567A1 (en) | 2011-10-11 | 2020-12-23 | Viela Bio, Inc. | Cd40l-specific tn3-derived scaffolds and methods of use thereof |
| MX2015005363A (es) * | 2012-11-08 | 2015-11-06 | Novozymes Biopharma Dk As | Variantes de albumina. |
-
2016
- 2016-03-11 AU AU2016228806A patent/AU2016228806B2/en active Active
- 2016-03-11 EP EP16762595.3A patent/EP3268389B1/en active Active
- 2016-03-11 KR KR1020177028780A patent/KR20170124592A/ko not_active Ceased
- 2016-03-11 CA CA3260163A patent/CA3260163A1/en active Pending
- 2016-03-11 ES ES16762595T patent/ES2839211T3/es active Active
- 2016-03-11 KR KR1020247016329A patent/KR20240093725A/ko active Pending
- 2016-03-11 CA CA2977675A patent/CA2977675A1/en active Pending
- 2016-03-11 CN CN201680014597.2A patent/CN107428817B/zh active Active
- 2016-03-11 WO PCT/US2016/022003 patent/WO2016145307A1/en not_active Ceased
- 2016-03-11 US US15/557,358 patent/US10683340B2/en active Active
- 2016-03-11 EP EP20198757.5A patent/EP3842451A1/en active Pending
- 2016-03-11 JP JP2017548053A patent/JP6862348B2/ja active Active
-
2017
- 2017-08-14 IL IL253971A patent/IL253971B/en unknown
-
2020
- 2020-06-15 US US16/901,812 patent/US11548933B2/en active Active
-
2021
- 2021-01-22 AU AU2021200423A patent/AU2021200423B2/en active Active
- 2021-03-31 JP JP2021061713A patent/JP7320550B2/ja active Active
-
2023
- 2023-01-06 US US18/150,983 patent/US20230340074A1/en active Pending
- 2023-05-16 JP JP2023080507A patent/JP7826243B2/ja active Active
- 2023-07-03 AU AU2023204271A patent/AU2023204271B2/en active Active
-
2026
- 2026-03-13 AU AU2026201911A patent/AU2026201911A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2023204271B2 (en) | 2026-04-02 |
| AU2016228806A1 (en) | 2017-08-31 |
| WO2016145307A1 (en) | 2016-09-15 |
| JP2018513124A (ja) | 2018-05-24 |
| CN107428817A (zh) | 2017-12-01 |
| IL253971A0 (en) | 2017-10-31 |
| EP3268389A1 (en) | 2018-01-17 |
| EP3268389A4 (en) | 2018-08-08 |
| US10683340B2 (en) | 2020-06-16 |
| JP6862348B2 (ja) | 2021-04-21 |
| AU2023204271A1 (en) | 2023-07-27 |
| JP7826243B2 (ja) | 2026-03-09 |
| US11548933B2 (en) | 2023-01-10 |
| AU2021200423A1 (en) | 2021-02-25 |
| AU2026201911A1 (en) | 2026-04-02 |
| AU2016228806B2 (en) | 2020-10-22 |
| KR20170124592A (ko) | 2017-11-10 |
| US20180105575A1 (en) | 2018-04-19 |
| US20230340074A1 (en) | 2023-10-26 |
| EP3842451A1 (en) | 2021-06-30 |
| ES2839211T3 (es) | 2021-07-05 |
| IL253971B (en) | 2021-10-31 |
| JP2023103368A (ja) | 2023-07-26 |
| EP3268389B1 (en) | 2020-09-30 |
| AU2021200423B2 (en) | 2023-04-06 |
| JP7320550B2 (ja) | 2023-08-03 |
| KR20240093725A (ko) | 2024-06-24 |
| JP2021105025A (ja) | 2021-07-26 |
| BR112017019401A2 (pt) | 2018-05-02 |
| CA2977675A1 (en) | 2016-09-15 |
| CN107428817B (zh) | 2022-07-12 |
| US20200407423A1 (en) | 2020-12-31 |
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