CA3241026A1 - Polyribonucleotides circulaires codant pour des polypeptides antifusogenes - Google Patents

Polyribonucleotides circulaires codant pour des polypeptides antifusogenes Download PDF

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Publication number
CA3241026A1
CA3241026A1 CA3241026A CA3241026A CA3241026A1 CA 3241026 A1 CA3241026 A1 CA 3241026A1 CA 3241026 A CA3241026 A CA 3241026A CA 3241026 A CA3241026 A CA 3241026A CA 3241026 A1 CA3241026 A1 CA 3241026A1
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Prior art keywords
polyribonucleotide
days
sequence
polypeptide
antifusogenic
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CA3241026A
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Gines Diego MIRALLES
Jesper Gromada
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Flagship Pioneering Innovations VI Inc
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Flagship Pioneering Innovations VI Inc
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    • A—HUMAN NECESSITIES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16045—Special targeting system for viral vectors
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
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  • Physics & Mathematics (AREA)
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  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Communicable Diseases (AREA)
  • Oncology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne, de manière générale, des compositions et des procédés de production, de purification et d'utilisation d'ARN circulaire codant pour un polypeptide antifusogène.
CA3241026A 2021-12-23 2022-12-23 Polyribonucleotides circulaires codant pour des polypeptides antifusogenes Pending CA3241026A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163293495P 2021-12-23 2021-12-23
US63/293,495 2021-12-23
PCT/US2022/082345 WO2023122789A1 (fr) 2021-12-23 2022-12-23 Polyribonucléotides circulaires codant pour des polypeptides antifusogènes

Publications (1)

Publication Number Publication Date
CA3241026A1 true CA3241026A1 (fr) 2023-06-29

Family

ID=85321278

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3241026A Pending CA3241026A1 (fr) 2021-12-23 2022-12-23 Polyribonucleotides circulaires codant pour des polypeptides antifusogenes

Country Status (6)

Country Link
KR (1) KR20240118881A (fr)
AU (1) AU2022420620A1 (fr)
CA (1) CA3241026A1 (fr)
IL (1) IL313714A (fr)
TW (1) TW202342064A (fr)
WO (1) WO2023122789A1 (fr)

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