CA3220753A1 - Salts of phenyl pyrrole aminoguanidine and polymorphs of phenyl pyrrole aminoguanidinium salts - Google Patents

Salts of phenyl pyrrole aminoguanidine and polymorphs of phenyl pyrrole aminoguanidinium salts Download PDF

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Publication number
CA3220753A1
CA3220753A1 CA3220753A CA3220753A CA3220753A1 CA 3220753 A1 CA3220753 A1 CA 3220753A1 CA 3220753 A CA3220753 A CA 3220753A CA 3220753 A CA3220753 A CA 3220753A CA 3220753 A1 CA3220753 A1 CA 3220753A1
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Canada
Prior art keywords
crystalline form
pyrrol
nitrophenyl
exhibiting
measured
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CA3220753A
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English (en)
French (fr)
Inventor
Thomas Boesen
Thomas Engelbrecht Nordkild Jonassen
Hayley Ann REECE
Natalie Louise KELK
Alice Jane TURNER
Ross MCLELLAN
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Synact Pharma ApS
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Synact Pharma ApS
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Publication of CA3220753A1 publication Critical patent/CA3220753A1/en
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
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CA3220753A 2021-06-21 2022-06-21 Salts of phenyl pyrrole aminoguanidine and polymorphs of phenyl pyrrole aminoguanidinium salts Pending CA3220753A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP21180708 2021-06-21
EP21180708.6 2021-06-21
EP21180702.9 2021-06-21
EP21180702 2021-06-21
EP21209855 2021-11-23
EP21209855.2 2021-11-23
PCT/EP2022/066884 WO2022268814A1 (en) 2021-06-21 2022-06-21 Salts of phenyl pyrrole aminoguanidine and polymorphs of phenyl pyrrole aminoguanidinium salts

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CA3220753A1 true CA3220753A1 (en) 2022-12-29

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CA3220753A Pending CA3220753A1 (en) 2021-06-21 2022-06-21 Salts of phenyl pyrrole aminoguanidine and polymorphs of phenyl pyrrole aminoguanidinium salts
CA3220756A Pending CA3220756A1 (en) 2021-06-21 2022-06-21 Phenyl pyrrole aminoguanidine salts and formulations

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US (3) US20230271922A9 (https=)
EP (3) EP4359076B1 (https=)
JP (2) JP2024523459A (https=)
KR (2) KR20240024818A (https=)
AU (2) AU2022296767A1 (https=)
BR (1) BR112023026909A2 (https=)
CA (2) CA3220753A1 (https=)
ES (1) ES3045575T3 (https=)
IL (2) IL309102A (https=)
MX (2) MX2023014174A (https=)
WO (2) WO2022268814A1 (https=)

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CN120617247A (zh) * 2020-03-31 2025-09-12 西奈克制药有限公司 症状性病毒性疾病的治疗
EP4359076B1 (en) * 2021-06-21 2025-08-06 SynAct Pharma ApS Phenyl pyrrole aminoguanidine salts and formulations
WO2023218048A1 (en) * 2022-05-12 2023-11-16 Synact Pharma Aps Resomelagon and its derivatives for the treatment of cardiovascular disease, hypertension and atherosclerosis
CN120584099A (zh) * 2022-12-21 2025-09-02 西奈克制药有限公司 苯基吡咯肼甲脒化合物的多晶型物
WO2025124760A1 (en) 2023-12-11 2025-06-19 Synact Pharma Aps Treatment of subpopulation of patients with rheumatoid arthritis

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SE9604348D0 (sv) 1996-11-26 1996-11-26 Wapharm Ab Användning av hydroxyguanidiner
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