CA3217021A1 - Combination of imetelstat and abt-199 for use in treating hematological cancers - Google Patents
Combination of imetelstat and abt-199 for use in treating hematological cancersInfo
- Publication number
- CA3217021A1 CA3217021A1 CA3217021A CA3217021A CA3217021A1 CA 3217021 A1 CA3217021 A1 CA 3217021A1 CA 3217021 A CA3217021 A CA 3217021A CA 3217021 A CA3217021 A CA 3217021A CA 3217021 A1 CA3217021 A1 CA 3217021A1
- Authority
- CA
- Canada
- Prior art keywords
- abt
- imetelstat
- leukemia
- lymphoma
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 229960001183 venetoclax Drugs 0.000 title claims abstract description 272
- LVZYXEALRXBLJZ-ISQYCPACSA-N f60ne4xb53 Chemical compound N1([C@@H]2O[C@@H]([C@H](C2)NP(O)(=S)OC[C@@H]2[C@H](C[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)NP(S)(=O)OC[C@@H]2[C@H](C[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)N)COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)N[C@H]2C[C@@H](O[C@@H]2COP(O)(=S)OCC(O)CNC(=O)CCCCCCCCCCCCCCC)N2C(NC(=O)C(C)=C2)=O)N2C3=NC=NC(N)=C3N=C2)N2C3=C(C(NC(N)=N3)=O)N=C2)N2C3=C(C(NC(N)=N3)=O)N=C2)N2C3=C(C(NC(N)=N3)=O)N=C2)N2C(NC(=O)C(C)=C2)=O)N2C(NC(=O)C(C)=C2)=O)N2C3=NC=NC(N)=C3N=C2)N2C3=C(C(NC(N)=N3)=O)N=C2)N2C3=NC=NC(N)=C3N=C2)C=CC(N)=NC1=O LVZYXEALRXBLJZ-ISQYCPACSA-N 0.000 title claims abstract description 100
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- IEVORMRANFJJFR-NMZIRJKDSA-A imetelstat sodium Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].N1([C@@H]2O[C@@H]([C@H](C2)NP([O-])(=S)OC[C@@H]2[C@H](C[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)NP([S-])(=O)OC[C@@H]2[C@H](C[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)N)COP([O-])(=S)N[C@H]2C[C@@H](O[C@@H]2COP([O-])(=S)N[C@H]2C[C@@H](O[C@@H]2COP([O-])(=S)N[C@H]2C[C@@H](O[C@@H]2COP([O-])(=S)N[C@H]2C[C@@H](O[C@@H]2COP([O-])(=S)N[C@H]2C[C@@H](O[C@@H]2COP([O-])(=S)N[C@H]2C[C@@H](O[C@@H]2COP([O-])(=S)N[C@H]2C[C@@H](O[C@@H]2COP([O-])(=S)N[C@H]2C[C@@H](O[C@@H]2COP([O-])(=S)N[C@H]2C[C@@H](O[C@@H]2COP([O-])(=S)N[C@H]2C[C@@H](O[C@@H]2COP([O-])(=S)OCC(O)CNC(=O)CCCCCCCCCCCCCCC)N2C(NC(=O)C(C)=C2)=O)N2C3=NC=NC(N)=C3N=C2)N2C3=C(C(NC(N)=N3)=O)N=C2)N2C3=C(C(NC(N)=N3)=O)N=C2)N2C3=C(C(NC(N)=N3)=O)N=C2)N2C(NC(=O)C(C)=C2)=O)N2C(NC(=O)C(C)=C2)=O)N2C3=NC=NC(N)=C3N=C2)N2C3=C(C(NC(N)=N3)=O)N=C2)N2C3=NC=NC(N)=C3N=C2)C=CC(N)=NC1=O IEVORMRANFJJFR-NMZIRJKDSA-A 0.000 claims abstract description 218
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Oncology (AREA)
- Hematology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Control Of Indicators Other Than Cathode Ray Tubes (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Peptides Or Proteins (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Developing Agents For Electrophotography (AREA)
- Glass Compositions (AREA)
- Photoreceptors In Electrophotography (AREA)
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EP16197293.0A EP3318276A1 (en) | 2016-11-04 | 2016-11-04 | Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers |
US201662422738P | 2016-11-16 | 2016-11-16 | |
US62/422,738 | 2016-11-16 | ||
CA3032118A CA3032118C (en) | 2016-08-02 | 2017-07-28 | Combination of imetelstat and abt-199 for use in treating hematological cancers |
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CA3032118A Division CA3032118C (en) | 2016-08-02 | 2017-07-28 | Combination of imetelstat and abt-199 for use in treating hematological cancers |
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CA3217021A Pending CA3217021A1 (en) | 2016-08-02 | 2017-07-28 | Combination of imetelstat and abt-199 for use in treating hematological cancers |
CA3032118A Active CA3032118C (en) | 2016-08-02 | 2017-07-28 | Combination of imetelstat and abt-199 for use in treating hematological cancers |
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EP (3) | EP3318276A1 (hr) |
JP (2) | JP7016856B2 (hr) |
KR (2) | KR102515378B1 (hr) |
CN (2) | CN109641002B (hr) |
AU (2) | AU2017305950B2 (hr) |
BR (1) | BR112019002025A2 (hr) |
CA (2) | CA3217021A1 (hr) |
CL (1) | CL2019000228A1 (hr) |
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ES (1) | ES2941462T3 (hr) |
FI (1) | FI3493812T3 (hr) |
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MD (1) | MD3493812T2 (hr) |
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RS (1) | RS64074B1 (hr) |
SG (1) | SG11201900883UA (hr) |
SI (1) | SI3493812T1 (hr) |
WO (1) | WO2018026646A1 (hr) |
ZA (1) | ZA201900939B (hr) |
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CN111801320A (zh) | 2018-01-10 | 2020-10-20 | 里科瑞尔姆Ip控股有限责任公司 | 苯甲酰胺化合物 |
JP2022533009A (ja) * | 2019-04-29 | 2022-07-21 | イミュノジェン, インコーポレイテッド | 抗cd123免疫複合体を含む治療的組み合わせ |
JP2024504367A (ja) * | 2021-01-22 | 2024-01-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | がんを治療及び改善するための方法 |
CN114949230A (zh) * | 2022-06-13 | 2022-08-30 | 厦门大学附属第一医院 | 一种预防和/或治疗急性髓系白血病的联合用药物组合物及其应用 |
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US5958680A (en) | 1994-07-07 | 1999-09-28 | Geron Corporation | Mammalian telomerase |
US5583016A (en) | 1994-07-07 | 1996-12-10 | Geron Corporation | Mammalian telomerase |
US5776679A (en) | 1994-07-07 | 1998-07-07 | Geron Corporation | Assays for the DNA component of human telomerase |
DK1210357T3 (da) | 1999-09-10 | 2008-07-21 | Geron Corp | Oligonukleotid-N3' -P5' -thiophosphoramidater: syntese og anvendelse deraf |
DK3342425T3 (da) | 2003-09-09 | 2020-03-16 | Geron Corp | Modificerede oligonukleotider til inhibering af telomerase |
EP1876893B1 (en) | 2005-04-15 | 2012-04-11 | Geron Corporation | Cancer treatment by combined inhibition of proteasome and telomerase activities |
WO2006113426A2 (en) | 2005-04-15 | 2006-10-26 | Geron Corporation | Cancer treatment by combined inhibition of telomerase and tubulin activities |
WO2006124904A2 (en) | 2005-05-16 | 2006-11-23 | Geron Corporation | Cancer treatment by combined inhibition of telomerase and hsp90 activities |
PT2101789E (pt) | 2006-10-30 | 2015-03-24 | Geron Corp | Inibidor de telomerase combinado e gencitabina para o tratamento de cancro |
WO2008094640A2 (en) | 2007-01-30 | 2008-08-07 | Geron Corporation | Compounds having anti-adhesive effects on cancer cells |
US9155753B2 (en) | 2007-03-09 | 2015-10-13 | Geron Corporation | Treatment of carcinomas with a combination of EGF-pathway and telomerase inhibitors |
US8877723B2 (en) | 2008-10-17 | 2014-11-04 | Geron Corporation | Method for identification of sensitivity of a patient to telomerase inhibition therapy |
WO2011017096A2 (en) * | 2009-08-04 | 2011-02-10 | Mayo Foundation For Medical Education And Research | Methods of treating hematologic cancers |
CA2890111A1 (en) | 2012-11-02 | 2014-05-08 | Pharmacyclics, Inc. | Tec family kinase inhibitor adjuvant therapy |
US9200327B2 (en) | 2012-11-30 | 2015-12-01 | Geron Corporation | Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors |
CA2892445C (en) | 2012-11-30 | 2022-06-28 | Geron Corporation | Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors |
US9375485B2 (en) | 2012-12-07 | 2016-06-28 | Geron Corporation | Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms |
DK3646876T3 (da) * | 2012-12-07 | 2024-05-06 | Geron Corp | Telomeraseinhibitoren imetelstat til behandling af myeloproliferative lidelser og myeloproliferative neoplasmer |
US9657057B2 (en) | 2013-03-14 | 2017-05-23 | Onyx Therapeutics, Inc. | Dipeptide and tripeptide epoxy ketone protease inhibitors |
WO2014160071A1 (en) * | 2013-03-14 | 2014-10-02 | St. Jude Children's Research Hospital | Methods and compositions for the treatment of glutamine-addicted cancers |
WO2015069758A1 (en) | 2013-11-06 | 2015-05-14 | Ayalew Tefferi | Methods and materials for treating hematological malignancies |
US11034757B2 (en) | 2014-06-09 | 2021-06-15 | Biomed Valley Discoveries, Inc. | Combination therapies using agents that target tumor-associated stroma or tumor cells and tumor vasculature |
US9635050B2 (en) | 2014-07-23 | 2017-04-25 | Cisco Technology, Inc. | Distributed supervised architecture for traffic segregation under attack |
AU2015323725B2 (en) | 2014-09-24 | 2022-03-03 | Exscientia Gmbh | Monolayer of PBMCs or bone-marrow cells and uses thereof |
JP7316261B2 (ja) | 2017-07-28 | 2023-07-27 | ジェロン・コーポレーション | 骨髄異形成症候群の治療方法 |
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2016
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2017
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