PT3493812T - Combinações de imetelstat e venetoclax para o tratamento da leucemia mielóide aguda - Google Patents
Combinações de imetelstat e venetoclax para o tratamento da leucemia mielóide agudaInfo
- Publication number
- PT3493812T PT3493812T PT177486131T PT17748613T PT3493812T PT 3493812 T PT3493812 T PT 3493812T PT 177486131 T PT177486131 T PT 177486131T PT 17748613 T PT17748613 T PT 17748613T PT 3493812 T PT3493812 T PT 3493812T
- Authority
- PT
- Portugal
- Prior art keywords
- combination treatment
- hematological cancers
- hematological
- cancers
- treatment
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 238000011284 combination treatment Methods 0.000 title 1
- 230000002489 hematologic effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16197293.0A EP3318276A1 (en) | 2016-11-04 | 2016-11-04 | Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3493812T true PT3493812T (pt) | 2023-03-30 |
Family
ID=57226888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT177486131T PT3493812T (pt) | 2016-11-04 | 2017-07-28 | Combinações de imetelstat e venetoclax para o tratamento da leucemia mielóide aguda |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US11278561B2 (pt) |
| EP (3) | EP3318276A1 (pt) |
| JP (2) | JP7016856B2 (pt) |
| KR (2) | KR102515378B1 (pt) |
| CN (2) | CN116327954A (pt) |
| AU (2) | AU2017305950B2 (pt) |
| BR (1) | BR112019002025A2 (pt) |
| CA (2) | CA3032118C (pt) |
| CL (1) | CL2019000228A1 (pt) |
| DK (1) | DK3493812T3 (pt) |
| ES (1) | ES2941462T3 (pt) |
| FI (1) | FI3493812T3 (pt) |
| HR (1) | HRP20230300T1 (pt) |
| HU (1) | HUE061471T2 (pt) |
| IL (2) | IL305332A (pt) |
| LT (1) | LT3493812T (pt) |
| MA (1) | MA45845A (pt) |
| MD (1) | MD3493812T2 (pt) |
| MX (2) | MX2019001315A (pt) |
| NZ (1) | NZ750191A (pt) |
| PL (1) | PL3493812T3 (pt) |
| PT (1) | PT3493812T (pt) |
| RS (1) | RS64074B1 (pt) |
| SG (1) | SG11201900883UA (pt) |
| SI (1) | SI3493812T1 (pt) |
| WO (1) | WO2018026646A1 (pt) |
| ZA (1) | ZA201900939B (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3737672A4 (en) | 2018-01-10 | 2021-09-15 | Recurium IP Holdings, LLC | BENZAMIDE COMPOUNDS |
| CN113853217A (zh) * | 2019-04-29 | 2021-12-28 | 伊缪诺金公司 | 包含抗cd123免疫缀合物的治疗组合 |
| EP4281560A1 (en) * | 2021-01-22 | 2023-11-29 | The Regents of the University of California | Methods for treating and ameliorating cancer |
| CN114949230A (zh) * | 2022-06-13 | 2022-08-30 | 厦门大学附属第一医院 | 一种预防和/或治疗急性髓系白血病的联合用药物组合物及其应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5958680A (en) | 1994-07-07 | 1999-09-28 | Geron Corporation | Mammalian telomerase |
| US5776679A (en) | 1994-07-07 | 1998-07-07 | Geron Corporation | Assays for the DNA component of human telomerase |
| US5583016A (en) | 1994-07-07 | 1996-12-10 | Geron Corporation | Mammalian telomerase |
| WO2001018015A1 (en) | 1999-09-10 | 2001-03-15 | Geron Corporation | Oligonucleotide n3'→p5' thiophosphoramidates: their synthesis and use |
| NZ545516A (en) | 2003-09-09 | 2009-06-26 | Geron Corp | Modified oligonucleotides for telomerase inhibition |
| WO2006113426A2 (en) | 2005-04-15 | 2006-10-26 | Geron Corporation | Cancer treatment by combined inhibition of telomerase and tubulin activities |
| WO2006113470A2 (en) | 2005-04-15 | 2006-10-26 | Geron Corporation | Cancer treatment by combined inhibition of proteasome and telomerase activities |
| WO2006124904A2 (en) | 2005-05-16 | 2006-11-23 | Geron Corporation | Cancer treatment by combined inhibition of telomerase and hsp90 activities |
| TR201819789T4 (tr) | 2006-10-30 | 2019-01-21 | Geron Corp | Kanser tedavisine yönelik gemsitabin ve kombine telomeraz inhibitörü. |
| WO2008094640A2 (en) | 2007-01-30 | 2008-08-07 | Geron Corporation | Compounds having anti-adhesive effects on cancer cells |
| WO2008112129A2 (en) | 2007-03-09 | 2008-09-18 | Geron Corporation | Treatment of carcinomas with a combination of egf-pathway and telomerase inhibitors |
| PT3330383T (pt) | 2008-10-17 | 2020-05-06 | Geron Corp | Grn163l para utiliização como inibidor de telomerase no tratamento de cancro |
| WO2011017096A2 (en) * | 2009-08-04 | 2011-02-10 | Mayo Foundation For Medical Education And Research | Methods of treating hematologic cancers |
| MX2015005633A (es) | 2012-11-02 | 2016-02-03 | Pharmacyclics Inc | Terapia adyuvante con inhibidores de quinasa de la familia tec. |
| KR20210112394A (ko) | 2012-11-30 | 2021-09-14 | 제론 코포레이션 | 텔로머라제 억제자로 세포 증식성 질환 치료용 진단 마커 |
| US9200327B2 (en) | 2012-11-30 | 2015-12-01 | Geron Corporation | Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors |
| US9375485B2 (en) | 2012-12-07 | 2016-06-28 | Geron Corporation | Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms |
| PL3456333T3 (pl) | 2012-12-07 | 2020-09-21 | Geron Corporation | Zastosowanie inhibitora telomerazy imetelstatu do leczenia zespołu mielodysplastycznego |
| WO2014160071A1 (en) * | 2013-03-14 | 2014-10-02 | St. Jude Children's Research Hospital | Methods and compositions for the treatment of glutamine-addicted cancers |
| CN105164117B (zh) | 2013-03-14 | 2019-02-01 | 欧尼斯治疗公司 | 二肽和三肽环氧酮蛋白酶抑制剂 |
| LT3065828T (lt) | 2013-11-06 | 2019-04-10 | Mayo Foundation For Medical Education And Research | Būdai ir medžiagos, skirti hematologinių piktybinių būklių gydymui |
| US11034757B2 (en) | 2014-06-09 | 2021-06-15 | Biomed Valley Discoveries, Inc. | Combination therapies using agents that target tumor-associated stroma or tumor cells and tumor vasculature |
| US9635050B2 (en) | 2014-07-23 | 2017-04-25 | Cisco Technology, Inc. | Distributed supervised architecture for traffic segregation under attack |
| EA201790504A1 (ru) * | 2014-09-24 | 2017-09-29 | Семм Форшунгсцентрум Фюр Молекуларе Медицин Гмбх | Монослой мононуклеарных клеток периферической крови или клеток костного мозга и его применение |
| AU2018307983A1 (en) | 2017-07-28 | 2020-02-13 | Geron Corporation | Methods of treating myelodysplastic syndrome |
-
2016
- 2016-11-04 EP EP16197293.0A patent/EP3318276A1/en not_active Withdrawn
-
2017
- 2017-07-28 EP EP22216202.6A patent/EP4218768A1/en active Pending
- 2017-07-28 MA MA045845A patent/MA45845A/fr unknown
- 2017-07-28 SG SG11201900883UA patent/SG11201900883UA/en unknown
- 2017-07-28 MD MDE20190665T patent/MD3493812T2/ro unknown
- 2017-07-28 RS RS20230227A patent/RS64074B1/sr unknown
- 2017-07-28 CA CA3032118A patent/CA3032118C/en active Active
- 2017-07-28 BR BR112019002025-0A patent/BR112019002025A2/pt active Search and Examination
- 2017-07-28 KR KR1020197005690A patent/KR102515378B1/ko active IP Right Grant
- 2017-07-28 CA CA3217021A patent/CA3217021A1/en active Pending
- 2017-07-28 AU AU2017305950A patent/AU2017305950B2/en active Active
- 2017-07-28 CN CN202211230655.9A patent/CN116327954A/zh active Pending
- 2017-07-28 WO PCT/US2017/044348 patent/WO2018026646A1/en unknown
- 2017-07-28 SI SI201731322T patent/SI3493812T1/sl unknown
- 2017-07-28 HR HRP20230300TT patent/HRP20230300T1/hr unknown
- 2017-07-28 LT LTEPPCT/US2017/044348T patent/LT3493812T/lt unknown
- 2017-07-28 KR KR1020237010185A patent/KR20230047206A/ko not_active Application Discontinuation
- 2017-07-28 PL PL17748613.1T patent/PL3493812T3/pl unknown
- 2017-07-28 NZ NZ750191A patent/NZ750191A/en unknown
- 2017-07-28 ES ES17748613T patent/ES2941462T3/es active Active
- 2017-07-28 HU HUE17748613A patent/HUE061471T2/hu unknown
- 2017-07-28 FI FIEP17748613.1T patent/FI3493812T3/fi active
- 2017-07-28 EP EP17748613.1A patent/EP3493812B1/en active Active
- 2017-07-28 MX MX2019001315A patent/MX2019001315A/es unknown
- 2017-07-28 IL IL305332A patent/IL305332A/en unknown
- 2017-07-28 DK DK17748613.1T patent/DK3493812T3/da active
- 2017-07-28 JP JP2019504731A patent/JP7016856B2/ja active Active
- 2017-07-28 CN CN201780048256.1A patent/CN109641002B/zh active Active
- 2017-07-28 PT PT177486131T patent/PT3493812T/pt unknown
- 2017-07-28 IL IL264451A patent/IL264451B2/en unknown
- 2017-07-28 US US15/662,706 patent/US11278561B2/en active Active
-
2019
- 2019-01-29 CL CL2019000228A patent/CL2019000228A1/es unknown
- 2019-01-30 MX MX2022010466A patent/MX2022010466A/es unknown
- 2019-02-13 ZA ZA2019/00939A patent/ZA201900939B/en unknown
-
2022
- 2022-02-11 US US17/670,278 patent/US20220168333A1/en active Pending
- 2022-08-12 JP JP2022128782A patent/JP2022145948A/ja active Pending
-
2023
- 2023-09-15 AU AU2023229592A patent/AU2023229592A1/en not_active Abandoned
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