CA3214045A1 - Compositions and methods for generating gamma-delta t cells from induced pluripotent stem cells - Google Patents

Compositions and methods for generating gamma-delta t cells from induced pluripotent stem cells Download PDF

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Publication number
CA3214045A1
CA3214045A1 CA3214045A CA3214045A CA3214045A1 CA 3214045 A1 CA3214045 A1 CA 3214045A1 CA 3214045 A CA3214045 A CA 3214045A CA 3214045 A CA3214045 A CA 3214045A CA 3214045 A1 CA3214045 A1 CA 3214045A1
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Prior art keywords
amino acid
acid sequence
seq
tcr
cell
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Pending
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CA3214045A
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English (en)
French (fr)
Inventor
Mark WALLET
Toshinobu Nishimura
Mark MENDONCA
Andriana LEBID
Brenda SALANTES
Katherine SANTOSTEFANO
Michael Francis NASO
Buddha GURUNG
Zengrong ZHU
Barry Morse
Luis Borges
Christina DEL CASALE
Marilda BEQIRI
Lucas THOMPSON
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Century Therapeutics Inc
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Century Therapeutics Inc
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Publication of CA3214045A1 publication Critical patent/CA3214045A1/en
Pending legal-status Critical Current

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/32—T-cell receptors [TCR]
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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    • A61K2039/804—Blood cells [leukemia, lymphoma]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/20—Cytokines; Chemokines
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CA3214045A 2021-04-07 2022-03-31 Compositions and methods for generating gamma-delta t cells from induced pluripotent stem cells Pending CA3214045A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163171646P 2021-04-07 2021-04-07
US63/171,646 2021-04-07
US202163279837P 2021-11-16 2021-11-16
US63/279,837 2021-11-16
PCT/US2022/022793 WO2022216514A1 (en) 2021-04-07 2022-03-31 Compositions and methods for generating gamma-delta t cells from induced pluripotent stem cells

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CA3214045A1 true CA3214045A1 (en) 2022-10-13

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CA3214045A Pending CA3214045A1 (en) 2021-04-07 2022-03-31 Compositions and methods for generating gamma-delta t cells from induced pluripotent stem cells

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US (2) US20220333073A1 (https=)
EP (1) EP4320227A1 (https=)
JP (1) JP2024519515A (https=)
KR (1) KR20230170703A (https=)
AU (1) AU2022252997A1 (https=)
BR (1) BR112023018844A2 (https=)
CA (1) CA3214045A1 (https=)
IL (1) IL307358A (https=)
MX (1) MX2023011927A (https=)
TW (1) TW202305113A (https=)
WO (1) WO2022216514A1 (https=)

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