CA3212203A1 - Novel cyclopenta[c]pyrrol negative allosteric modulators of nr2b - Google Patents
Novel cyclopenta[c]pyrrol negative allosteric modulators of nr2b Download PDFInfo
- Publication number
- CA3212203A1 CA3212203A1 CA3212203A CA3212203A CA3212203A1 CA 3212203 A1 CA3212203 A1 CA 3212203A1 CA 3212203 A CA3212203 A CA 3212203A CA 3212203 A CA3212203 A CA 3212203A CA 3212203 A1 CA3212203 A1 CA 3212203A1
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- CA
- Canada
- Prior art keywords
- pyrrol
- hydroxy
- phenoxyhexahydrocyclopenta
- dihydroquinolin
- hydroxyethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Engineering & Computer Science (AREA)
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- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163166516P | 2021-03-26 | 2021-03-26 | |
| US63/166,516 | 2021-03-26 | ||
| PCT/US2022/021624 WO2022204336A1 (en) | 2021-03-26 | 2022-03-24 | Novel cyclopental[c]pyrrol negative allosteric modulators of nr2b |
Publications (1)
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|---|---|
| CA3212203A1 true CA3212203A1 (en) | 2022-09-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA3212203A Pending CA3212203A1 (en) | 2021-03-26 | 2022-03-24 | Novel cyclopenta[c]pyrrol negative allosteric modulators of nr2b |
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| EP (1) | EP4313041A1 (pt) |
| JP (1) | JP2024509325A (pt) |
| KR (1) | KR20230160906A (pt) |
| CN (1) | CN117157072A (pt) |
| AR (1) | AR125594A1 (pt) |
| AU (1) | AU2022244367A1 (pt) |
| BR (1) | BR112023018766A2 (pt) |
| CA (1) | CA3212203A1 (pt) |
| CO (1) | CO2023012711A2 (pt) |
| CR (1) | CR20230458A (pt) |
| DO (1) | DOP2023000205A (pt) |
| EC (1) | ECSP23073082A (pt) |
| IL (1) | IL305601A (pt) |
| TW (1) | TW202304885A (pt) |
| UY (1) | UY39688A (pt) |
| WO (1) | WO2022204336A1 (pt) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2879126A1 (en) * | 2012-07-19 | 2014-01-23 | Janssen Pharmaceutica Nv | Octahydro-cyclopentapyrrolyl antagonists of ccr2 |
| JO3579B1 (ar) * | 2014-09-26 | 2020-07-05 | Luc Therapeutics Inc | مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول |
| CN107849009B (zh) * | 2015-10-13 | 2021-03-02 | 四川海思科制药有限公司 | 一种八氢环戊二烯并[c]吡咯衍生物及其制备方法和在医药上的用途 |
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2022
- 2022-03-24 UY UY0001039688A patent/UY39688A/es unknown
- 2022-03-24 EP EP22776608.6A patent/EP4313041A1/en active Pending
- 2022-03-24 IL IL305601A patent/IL305601A/en unknown
- 2022-03-24 WO PCT/US2022/021624 patent/WO2022204336A1/en active Application Filing
- 2022-03-24 TW TW111111135A patent/TW202304885A/zh unknown
- 2022-03-24 CA CA3212203A patent/CA3212203A1/en active Pending
- 2022-03-24 AU AU2022244367A patent/AU2022244367A1/en active Pending
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2023
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- 2023-09-26 CO CONC2023/0012711A patent/CO2023012711A2/es unknown
- 2023-09-26 EC ECSENADI202373082A patent/ECSP23073082A/es unknown
Also Published As
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|---|---|
| DOP2023000205A (es) | 2023-11-15 |
| ECSP23073082A (es) | 2023-10-31 |
| UY39688A (es) | 2022-10-31 |
| EP4313041A1 (en) | 2024-02-07 |
| WO2022204336A1 (en) | 2022-09-29 |
| AU2022244367A1 (en) | 2023-09-07 |
| CO2023012711A2 (es) | 2023-10-19 |
| CR20230458A (es) | 2023-10-27 |
| IL305601A (en) | 2023-11-01 |
| BR112023018766A2 (pt) | 2023-10-24 |
| AR125594A1 (es) | 2023-08-02 |
| CN117157072A (zh) | 2023-12-01 |
| TW202304885A (zh) | 2023-02-01 |
| JP2024509325A (ja) | 2024-02-29 |
| KR20230160906A (ko) | 2023-11-24 |
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