CA3171623A1 - Extracellular vesicles for therapy - Google Patents

Extracellular vesicles for therapy Download PDF

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Publication number
CA3171623A1
CA3171623A1 CA3171623A CA3171623A CA3171623A1 CA 3171623 A1 CA3171623 A1 CA 3171623A1 CA 3171623 A CA3171623 A CA 3171623A CA 3171623 A CA3171623 A CA 3171623A CA 3171623 A1 CA3171623 A1 CA 3171623A1
Authority
CA
Canada
Prior art keywords
antigen
scaffold
linked
moiety
aspects
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3171623A
Other languages
English (en)
French (fr)
Inventor
Sriram Sathyanarayanan
Tim SOOS
Ke Xu
Aaron Noyes
Kevin P. Dooley
Eric Zhang
Christine MCCOY
Jonathan Finn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza Sales AG
Original Assignee
Codiak Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2020/024023 external-priority patent/WO2020191361A2/en
Application filed by Codiak Biosciences Inc filed Critical Codiak Biosciences Inc
Publication of CA3171623A1 publication Critical patent/CA3171623A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20071—Demonstrated in vivo effect
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CA3171623A 2020-03-20 2021-03-22 Extracellular vesicles for therapy Pending CA3171623A1 (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
PCT/US2020/024023 WO2020191361A2 (en) 2019-03-21 2020-03-20 Extracellular vesicles for vaccine delivery
USPCT/US2020/024023 2020-03-20
US202063001088P 2020-03-27 2020-03-27
US63/001,088 2020-03-27
US202063003171P 2020-03-31 2020-03-31
US63/003,171 2020-03-31
US202063006585P 2020-04-07 2020-04-07
US63/006,585 2020-04-07
US202063017514P 2020-04-29 2020-04-29
US63/017,514 2020-04-29
US202163142418P 2021-01-27 2021-01-27
US63/142,418 2021-01-27
PCT/US2021/023485 WO2021189047A2 (en) 2020-03-20 2021-03-22 Extracellular vesicles for therapy

Publications (1)

Publication Number Publication Date
CA3171623A1 true CA3171623A1 (en) 2021-09-23

Family

ID=77771656

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3171623A Pending CA3171623A1 (en) 2020-03-20 2021-03-22 Extracellular vesicles for therapy

Country Status (6)

Country Link
US (1) US20250114445A1 (https=)
EP (1) EP4121450A2 (https=)
JP (1) JP2023518414A (https=)
AU (1) AU2021236763A1 (https=)
CA (1) CA3171623A1 (https=)
WO (1) WO2021189047A2 (https=)

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US20250000967A1 (en) * 2021-11-10 2025-01-02 Ck-Exogene Co., Ltd. Exosome-based antiviral vaccine and manufacturing method thereof
WO2023230233A1 (en) * 2022-05-25 2023-11-30 Malcolm Thomas Allogeneic hypoimmune biomimetic nanovesicle for the treatment of cancer
KR20240010702A (ko) * 2022-07-13 2024-01-24 (주)엑솔런스 항원 단백질 또는 상기 단백질을 암호화하는 유전자를포함하는 세포외소포체 및 그의 용도
US20260055404A1 (en) * 2022-08-17 2026-02-26 Lonza Sales Ag Extracellular vesicle comprising a biologically active molecule and a cell penetrating peptide cleavable linker
WO2024237866A1 (en) * 2023-05-17 2024-11-21 National University Of Singapore Surface display of immunotherapeutics on extracellular vesicles and uses thereof

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Also Published As

Publication number Publication date
WO2021189047A2 (en) 2021-09-23
AU2021236763A1 (en) 2022-10-06
JP2023518414A (ja) 2023-05-01
US20250114445A1 (en) 2025-04-10
WO2021189047A3 (en) 2021-11-04
EP4121450A2 (en) 2023-01-25

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