CA3166533A1 - Anti-cd73 antibodies and uses thereof - Google Patents

Anti-cd73 antibodies and uses thereof

Info

Publication number
CA3166533A1
CA3166533A1 CA3166533A CA3166533A CA3166533A1 CA 3166533 A1 CA3166533 A1 CA 3166533A1 CA 3166533 A CA3166533 A CA 3166533A CA 3166533 A CA3166533 A CA 3166533A CA 3166533 A1 CA3166533 A1 CA 3166533A1
Authority
CA
Canada
Prior art keywords
seq
amino acid
antibody
acid sequence
set forth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3166533A
Other languages
English (en)
French (fr)
Inventor
Horacio G. Nastri
Shaun M. STEWART
Juan Carlos Almagro
Jing Zhou
Rebecca A. Buonpane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of CA3166533A1 publication Critical patent/CA3166533A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3166533A 2020-01-03 2020-12-30 Anti-cd73 antibodies and uses thereof Pending CA3166533A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062956847P 2020-01-03 2020-01-03
US62/956,847 2020-01-03
PCT/US2020/067533 WO2021138467A1 (en) 2020-01-03 2020-12-30 Anti-cd73 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
CA3166533A1 true CA3166533A1 (en) 2021-07-08

Family

ID=74347717

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3166533A Pending CA3166533A1 (en) 2020-01-03 2020-12-30 Anti-cd73 antibodies and uses thereof

Country Status (19)

Country Link
US (2) US12018089B2 (enExample)
EP (1) EP4084825A1 (enExample)
JP (1) JP2023509448A (enExample)
KR (1) KR20220121850A (enExample)
CN (1) CN115135341A (enExample)
AR (1) AR120936A1 (enExample)
AU (1) AU2020417804A1 (enExample)
BR (1) BR112022013236A2 (enExample)
CA (1) CA3166533A1 (enExample)
CL (2) CL2022001769A1 (enExample)
CO (1) CO2022009248A2 (enExample)
CR (1) CR20220317A (enExample)
EC (1) ECSP22051701A (enExample)
IL (1) IL294436A (enExample)
MX (1) MX2022007575A (enExample)
PE (1) PE20221409A1 (enExample)
PH (1) PH12022551636A1 (enExample)
TW (1) TWI873265B (enExample)
WO (1) WO2021138467A1 (enExample)

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Also Published As

Publication number Publication date
CL2024002235A1 (es) 2024-12-27
BR112022013236A2 (pt) 2022-09-06
CR20220317A (es) 2022-09-02
KR20220121850A (ko) 2022-09-01
JP2023509448A (ja) 2023-03-08
ECSP22051701A (es) 2022-08-31
PE20221409A1 (es) 2022-09-20
CL2022001769A1 (es) 2023-01-20
US12018089B2 (en) 2024-06-25
AU2020417804A1 (en) 2022-07-21
US20210230293A1 (en) 2021-07-29
IL294436A (en) 2022-09-01
AR120936A1 (es) 2022-03-30
CO2022009248A2 (es) 2022-08-19
TWI873265B (zh) 2025-02-21
PH12022551636A1 (en) 2024-01-08
CN115135341A (zh) 2022-09-30
MX2022007575A (es) 2022-09-23
EP4084825A1 (en) 2022-11-09
WO2021138467A1 (en) 2021-07-08
US20240352143A1 (en) 2024-10-24
TW202128768A (zh) 2021-08-01

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