CA3161156A1 - Improved synthesis of kras g12c inhibitor compound - Google Patents
Improved synthesis of kras g12c inhibitor compoundInfo
- Publication number
- CA3161156A1 CA3161156A1 CA3161156A CA3161156A CA3161156A1 CA 3161156 A1 CA3161156 A1 CA 3161156A1 CA 3161156 A CA3161156 A CA 3161156A CA 3161156 A CA3161156 A CA 3161156A CA 3161156 A1 CA3161156 A1 CA 3161156A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- cancer
- usa
- equiv
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962935515P | 2019-11-14 | 2019-11-14 | |
| US62/935,515 | 2019-11-14 | ||
| PCT/US2020/060415 WO2021097207A1 (en) | 2019-11-14 | 2020-11-13 | Improved synthesis of kras g12c inhibitor compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3161156A1 true CA3161156A1 (en) | 2021-05-20 |
Family
ID=73740592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3161156A Pending CA3161156A1 (en) | 2019-11-14 | 2020-11-13 | Improved synthesis of kras g12c inhibitor compound |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US12473281B2 (https=) |
| EP (1) | EP4058432A1 (https=) |
| JP (1) | JP7837865B2 (https=) |
| AR (1) | AR120456A1 (https=) |
| AU (1) | AU2020383535B2 (https=) |
| CA (1) | CA3161156A1 (https=) |
| MX (1) | MX2022005726A (https=) |
| TW (1) | TW202132271A (https=) |
| WO (1) | WO2021097207A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201992781A1 (ru) | 2017-05-22 | 2020-04-01 | Эмджен Инк. | Ингибиторы g12c kras и способы их применения |
| ES3060664T3 (en) | 2018-06-12 | 2026-03-27 | Amgen Inc | Kras g12c inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer |
| JP7516029B2 (ja) | 2018-11-16 | 2024-07-16 | アムジエン・インコーポレーテツド | Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法 |
| JP7377679B2 (ja) | 2018-11-19 | 2023-11-10 | アムジエン・インコーポレーテツド | がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法 |
| EP3738593A1 (en) | 2019-05-14 | 2020-11-18 | Amgen, Inc | Dosing of kras inhibitor for treatment of cancers |
| NZ782284A (en) | 2019-05-21 | 2024-11-29 | Amgen Inc | Solid state forms |
| AU2020277398B2 (en) | 2019-05-21 | 2026-01-29 | Amgen Inc. | Solid state forms |
| EP4029853A4 (en) * | 2019-09-11 | 2023-03-01 | Chiral Quest (suzhou) Co., Ltd. | SYNTHETIC METHOD APPLIED TO A HETEROCYCLIC INTERMEDIATE OF KRAS INHIBITOR DRUGS |
| JP2023501528A (ja) | 2019-11-14 | 2023-01-18 | アムジエン・インコーポレーテツド | Ｋｒａｓ ｇ１２ｃ阻害剤化合物の改善された合成 |
| WO2021097207A1 (en) | 2019-11-14 | 2021-05-20 | Amgen Inc. | Improved synthesis of kras g12c inhibitor compound |
| WO2021244555A1 (zh) * | 2020-06-02 | 2021-12-09 | 上海喆邺生物科技有限公司 | 一种手性中间体及其制备方法 |
| CN116507624A (zh) | 2020-11-20 | 2023-07-28 | 美国安进公司 | 制备7-氯-6-氟-1-(2-异丙基-4-甲基吡啶-3-基)吡啶并f[2,3-d]嘧啶-2,4(1h,3h)-二酮的方法 |
| CN113666865B (zh) * | 2021-09-07 | 2023-05-26 | 杭州科耀医药科技有限公司 | 一种2-异丙基-3-氨基-4-甲基吡啶的合成方法 |
| PL4426303T3 (pl) | 2021-11-02 | 2026-02-09 | Semmelweis Egyetem | Inhibitory transferazy farnezylowej i inhibitory kras do leczenia nowotworów z mutacją kras |
| WO2023172858A1 (en) | 2022-03-07 | 2023-09-14 | Amgen Inc. | A process for preparing 4-methyl-2-propan-2-yl-pyridine-3-carbonitrile |
| CN114907259A (zh) * | 2022-04-28 | 2022-08-16 | 常州中氪生命科学技术有限公司 | 一种索托拉西布中间体的合成方法 |
| CN115466259B (zh) * | 2022-08-16 | 2023-12-05 | 山东大学 | 一种kras g12c抑制剂索托拉西布的制备方法 |
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2020
- 2020-11-13 WO PCT/US2020/060415 patent/WO2021097207A1/en not_active Ceased
- 2020-11-13 CA CA3161156A patent/CA3161156A1/en active Pending
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- 2020-11-13 US US17/776,950 patent/US12473281B2/en active Active
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- 2020-11-13 TW TW109139728A patent/TW202132271A/zh unknown
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| US20260028339A1 (en) | 2026-01-29 |
| WO2021097207A1 (en) | 2021-05-20 |
| JP7837865B2 (ja) | 2026-03-31 |
| JP2023501522A (ja) | 2023-01-18 |
| EP4058432A1 (en) | 2022-09-21 |
| TW202132271A (zh) | 2021-09-01 |
| AU2020383535B2 (en) | 2026-03-19 |
| MX2022005726A (es) | 2022-06-09 |
| US20230192682A1 (en) | 2023-06-22 |
| AU2020383535A1 (en) | 2022-05-05 |
| US20250206736A1 (en) | 2025-06-26 |
| US12473281B2 (en) | 2025-11-18 |
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