CA3154761A1 - Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease - Google Patents

Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease

Info

Publication number
CA3154761A1
CA3154761A1 CA3154761A CA3154761A CA3154761A1 CA 3154761 A1 CA3154761 A1 CA 3154761A1 CA 3154761 A CA3154761 A CA 3154761A CA 3154761 A CA3154761 A CA 3154761A CA 3154761 A1 CA3154761 A1 CA 3154761A1
Authority
CA
Canada
Prior art keywords
alvelestat
subject
gvhd
pharmaceutically acceptable
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3154761A
Other languages
English (en)
French (fr)
Inventor
Jacqueline PARKIN
Anthony SUNG
Steven Z Pavletic
Annie IM
Noa G Holtzman
Cody J. PEER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mereo Biopharma 4 Ltd
Duke University
US Department of Health and Human Services
Original Assignee
Mereo Biopharma 4 Ltd
Duke University
National Cancer Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mereo Biopharma 4 Ltd, Duke University, National Cancer Institute filed Critical Mereo Biopharma 4 Ltd
Publication of CA3154761A1 publication Critical patent/CA3154761A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3154761A 2019-09-17 2020-09-17 Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease Pending CA3154761A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962901638P 2019-09-17 2019-09-17
US62/901,638 2019-09-17
PCT/EP2020/075948 WO2021053058A1 (en) 2019-09-17 2020-09-17 Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease

Publications (1)

Publication Number Publication Date
CA3154761A1 true CA3154761A1 (en) 2021-03-25

Family

ID=72560598

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3154761A Pending CA3154761A1 (en) 2019-09-17 2020-09-17 Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease

Country Status (10)

Country Link
US (1) US20220354833A1 (https=)
EP (1) EP4031138A1 (https=)
JP (1) JP7672641B2 (https=)
KR (1) KR20220079527A (https=)
CN (1) CN114650819A (https=)
AU (1) AU2020349353A1 (https=)
BR (1) BR112022004861A2 (https=)
CA (1) CA3154761A1 (https=)
IL (1) IL290991A (https=)
WO (1) WO2021053058A1 (https=)

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US10894960B2 (en) 2016-08-30 2021-01-19 Children's Hospital Medical Center Compositions and methods for nucleic acid transfer
US12411144B2 (en) 2017-03-22 2025-09-09 Children's Hospital Medical Center Compositions and methods for treatment of lung function
IL297211B2 (en) * 2020-04-16 2025-12-01 Mereo Biopharma 4 Ltd Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
KR20240090272A (ko) 2021-10-20 2024-06-21 메레오 바이오파마 4 리미티드 섬유화 치료에 사용하기 위한 호중구 엘라스테이스 억제제
WO2023212288A1 (en) * 2022-04-28 2023-11-02 Children's Hospital Medical Center Methods for improving outcomes for hematopoietic cell transplant recipients at risk for bronchiolitis obliterans syndrome
GB202319953D0 (en) * 2023-12-22 2024-02-07 Mereo Biopharma 4 Ltd Tablet formulations involving alvelestat

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Also Published As

Publication number Publication date
CN114650819A (zh) 2022-06-21
JP2023500182A (ja) 2023-01-05
BR112022004861A2 (pt) 2022-06-07
IL290991A (en) 2022-05-01
WO2021053058A1 (en) 2021-03-25
AU2020349353A1 (en) 2022-04-14
KR20220079527A (ko) 2022-06-13
US20220354833A1 (en) 2022-11-10
JP7672641B2 (ja) 2025-05-08
EP4031138A1 (en) 2022-07-27

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