CA3146949A1 - Method of engrafting cells from solid tissues - Google Patents

Method of engrafting cells from solid tissues

Info

Publication number
CA3146949A1
CA3146949A1 CA3146949A CA3146949A CA3146949A1 CA 3146949 A1 CA3146949 A1 CA 3146949A1 CA 3146949 A CA3146949 A CA 3146949A CA 3146949 A CA3146949 A CA 3146949A CA 3146949 A1 CA3146949 A1 CA 3146949A1
Authority
CA
Canada
Prior art keywords
cells
mixture
use according
liver
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3146949A
Other languages
English (en)
French (fr)
Inventor
Rachael Turner
David Gerber
Oswaldo Lozoya
Lola M. Reid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Original Assignee
University of North Carolina at Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill filed Critical University of North Carolina at Chapel Hill
Publication of CA3146949A1 publication Critical patent/CA3146949A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/734—Alginic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/28—Materials or treatment for tissue regeneration for liver reconstruction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/80—Hyaluronan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2537/00—Supports and/or coatings for cell culture characterised by physical or chemical treatment
    • C12N2537/10—Cross-linking
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Nutrition Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Botany (AREA)
  • Neurosurgery (AREA)
CA3146949A 2010-05-07 2011-05-06 Method of engrafting cells from solid tissues Pending CA3146949A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33244110P 2010-05-07 2010-05-07
US61/332,441 2010-05-07
CA2798458A CA2798458C (en) 2010-05-07 2011-05-06 Method of engrafting cells from solid tissues

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2798458A Division CA2798458C (en) 2010-05-07 2011-05-06 Method of engrafting cells from solid tissues

Publications (1)

Publication Number Publication Date
CA3146949A1 true CA3146949A1 (en) 2011-11-10

Family

ID=44902076

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2798458A Active CA2798458C (en) 2010-05-07 2011-05-06 Method of engrafting cells from solid tissues
CA3146949A Pending CA3146949A1 (en) 2010-05-07 2011-05-06 Method of engrafting cells from solid tissues

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2798458A Active CA2798458C (en) 2010-05-07 2011-05-06 Method of engrafting cells from solid tissues

Country Status (19)

Country Link
US (1) US20110274666A1 (OSRAM)
EP (1) EP2566567A4 (OSRAM)
JP (4) JP6177687B2 (OSRAM)
KR (4) KR102493613B1 (OSRAM)
CN (2) CN102985130A (OSRAM)
AR (1) AR081906A1 (OSRAM)
AU (1) AU2011247984B2 (OSRAM)
BR (1) BR112012028265B1 (OSRAM)
CA (2) CA2798458C (OSRAM)
CL (1) CL2012003085A1 (OSRAM)
CR (1) CR20120603A (OSRAM)
IL (3) IL222857A (OSRAM)
MX (3) MX359678B (OSRAM)
NZ (2) NZ603913A (OSRAM)
PH (1) PH12012502176A1 (OSRAM)
RU (1) RU2736955C2 (OSRAM)
SG (2) SG185425A1 (OSRAM)
TW (3) TW201202424A (OSRAM)
WO (1) WO2011140428A1 (OSRAM)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
US8961617B2 (en) * 2012-03-08 2015-02-24 Liventa Bioscience, Inc. Amnion and chorion constructs and uses thereof in abdominal surgery
US9533013B2 (en) 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
EP2886644A1 (en) * 2013-12-20 2015-06-24 Kallistem Process for implementing in vitro spermatogenesis and associated device
US10765705B2 (en) 2014-11-24 2020-09-08 Prime Merger Sub, Llc Visco-supplement compositions, and methods of use thereof
WO2016118950A1 (en) * 2015-01-23 2016-07-28 Everon Biosciences, Inc. Induction of cellular senescence for tissue therapies
CN106148266A (zh) * 2015-04-20 2016-11-23 烟台赛泽生物技术有限公司 一种免疫细胞用培养基及该培养基的添加剂
JP2016209303A (ja) * 2015-05-08 2016-12-15 レジエンス株式会社 肝組織を再生するための製剤
US20170369849A1 (en) * 2016-05-11 2017-12-28 The University Of North Carolina At Chapel Hill Compositions and methods for bioengineered tissues
EP3520746A4 (en) 2016-09-30 2020-05-06 Taipei Veterans General Hospital ANTIFREEZE AGENT FOR PROTECTING BIOLOGICAL TISSUE DURING FREEZING TREATMENT AND PREPARATION METHOD THEREOF
SG11201908905SA (en) * 2017-04-06 2019-10-30 Univ North Carolina Chapel Hill Cryopreservation method
CA3066710A1 (en) 2017-06-12 2018-12-20 The University Of North Carolina At Chapel Hill Patch graft compositions for cell engraftment
ES2989582T3 (es) 2018-05-03 2024-11-27 Collplant Ltd Rellenos dérmicos y aplicaciones de los mismos
JP2020050625A (ja) 2018-09-27 2020-04-02 株式会社北里コーポレーション 卵巣組織の移植方法および卵胞活性化方法
JP7350505B2 (ja) * 2019-02-15 2023-09-26 イビデン株式会社 生体試料を含む固化体
US20230039816A1 (en) * 2019-09-27 2023-02-09 Public University Corporation Yokohama City University Method for inducing hepatocyte plasticity
WO2023042875A1 (ja) * 2021-09-16 2023-03-23 富士フイルム株式会社 ゲル形成キット及びその利用
JP7440987B2 (ja) * 2021-12-28 2024-02-29 株式会社ポル・メド・テック 移植材料の製造方法、及び移植材料
KR20250056904A (ko) * 2022-08-24 2025-04-28 가부시키가이샤 비타 형광 표지용 조성물, 형광 프로브, 주입제, 시린지 충전물, 의료 기구, 의료용 섬유 소재, 형광 표지용 조성물의 제조 방법 및 의료용 섬유 소재의 제조 방법
CN116920263A (zh) * 2023-07-28 2023-10-24 南方医科大学南方医院 一种透皮递送活体干细胞的冷冻微针及其制备方法和应用
CN117426368A (zh) * 2023-10-08 2024-01-23 北京汇智泰康医药技术有限公司 一种肝细胞冻存液及其应用

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6231881B1 (en) * 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
US20040138329A1 (en) * 1992-04-20 2004-07-15 Board Of Regents Of The University Of Texas System Gels for encapsulation of biological materials
WO1994003154A1 (en) * 1992-07-29 1994-02-17 Washington University Use of pouch for implantation of living cells
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5681587A (en) * 1995-10-06 1997-10-28 Desmos, Inc. Growth of adult pancreatic islet cells
US6482231B1 (en) * 1995-11-20 2002-11-19 Giovanni Abatangelo Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative
EP0915967A1 (en) * 1996-05-28 1999-05-19 The Board Of Regents Of The University Of Michigan Engineering oral tissues
US6224893B1 (en) * 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
JP3014343B2 (ja) * 1997-06-06 2000-02-28 科学技術振興事業団 肝細胞の培養方法
IT1293484B1 (it) * 1997-06-11 1999-03-01 Fidia Advanced Biopolymers Srl Materiale biologico comprendente una efficiente coltura di cellule e una matrice tridimensionale biocompatibile e biodegradabile
US6129911A (en) * 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
US20020182188A1 (en) * 1999-01-19 2002-12-05 Reid Lola M. Human liver progenitors
US6592623B1 (en) * 1999-08-31 2003-07-15 Virginia Commonwealth University Intellectual Property Foundation Engineered muscle
US6365385B1 (en) * 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
WO2000066036A2 (en) * 1999-04-30 2000-11-09 Massachusetts General Hospital Fabrication of vascularized tissue using microfabricated two-dimensional molds
AU6092900A (en) * 1999-07-14 2001-02-05 Board Of Trustees Of The Leland Stanford Junior University Animals comprising human hepatocellular tissue
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
RU2165263C1 (ru) * 2000-06-23 2001-04-20 Зыбин Дмитрий Владимирович Способ лечения сахарного диабета
US7291673B2 (en) * 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US6435190B1 (en) * 2000-06-14 2002-08-20 Syde A. Taheri Autogenous cell patch cardio myoplasty and advanced muscle graft implantation system
MY130475A (en) * 2000-08-25 2007-06-29 Contura As Polyacrylamide hydrogel and its use as an endoprosthesis
JP2004514778A (ja) * 2000-11-28 2004-05-20 フォーカル　インコーポレーティッド ポリアルキレングリコール粘度増強性重合製剤
US20030077566A1 (en) * 2001-09-10 2003-04-24 Palasz Andrzej T. Method for cryopreserving mammalian cells and tissues
EP1539282A2 (en) * 2002-08-06 2005-06-15 GenVec, Inc. Improved injection system
WO2004034890A2 (en) * 2002-10-17 2004-04-29 Vacanti, Joseph, P. Biological scaffolding material
WO2004098285A2 (en) * 2003-05-08 2004-11-18 Cellartis Ab Cryopreservation of human blastocyst-derived stem cells by use of a closed straw vitrification method
JP2007503840A (ja) * 2003-09-02 2007-03-01 ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 生分解性ポリマー−リガンド結合体、及び、細胞亜集団の単離、細胞の凍結保存、培養及び移植に生分解性ポリマー−リガンド結合体を用いる方法
EP1664282A4 (en) * 2003-09-19 2008-04-09 Newsouth Innovations Pty Ltd METHOD FOR ISOLATING HEPATOCYTES
WO2005056763A2 (en) * 2003-12-04 2005-06-23 University Of Utah Research Foundation Process and formulation to improve viability of stored cells and tissue
US7884185B2 (en) * 2004-07-28 2011-02-08 University Of Delaware Hydrogels and uses thereof
US8828433B2 (en) * 2005-04-19 2014-09-09 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
WO2007059501A2 (en) * 2005-11-16 2007-05-24 University Of North Carolina At Chapel Hill Extracellular matrix components for expansion or differentiation of hepatic progenitors
EP2033513A1 (en) * 2006-05-30 2009-03-11 Instituto Nacional De Investigacion y Tecnologia agraria y Alimentaria (INIA) Procedure for the preparation of unilamellar vesicles for cryopreservation and the culture of stem cells and embryos
TW200817019A (en) * 2006-07-10 2008-04-16 Univ Columbia De novo formation and regeneration of vascularized tissue from tissue progenitor cells and vascular progenitor cells
AU2007297611B2 (en) * 2006-09-21 2013-02-07 Purdue Research Foundation Collagen preparation and method of isolation
US20080233088A1 (en) * 2007-02-16 2008-09-25 Varian Medical Systems Technologies, Inc. Preparative regimen for engraftment, growth and differentiation of non-hematopoeitic cells in vivo after transplantation
US20080248570A1 (en) * 2007-03-06 2008-10-09 University Of North Carolina At Chapel Hill Complexes of hyaluronans, other matrix components, hormones and growth factors for maintenance, expansion and/or differentiation of cells
US20080311045A1 (en) * 2007-06-06 2008-12-18 Biovaluation & Analysis, Inc. Polymersomes for Use in Acoustically Mediated Intracellular Drug Delivery in vivo
BRPI0813353A2 (pt) * 2007-06-15 2014-10-14 Univ North Carolina Sinais parácrinos de células alimentadoras mesenquimais e regulação da expansão e diferenciação de progenitores hepáticos usando os mesmos
GB0713079D0 (en) * 2007-07-05 2007-08-15 Ucl Business Plc biomaterial scaffolds with defined stiffness
CA2695971A1 (en) * 2007-08-15 2009-02-19 Ramot At Tel Aviv University, Ltd. Polypeptides, matrices, hydrogels and methods of using same for tissue regeneration and repair
US20110178182A1 (en) * 2007-08-20 2011-07-21 Do-Coop Technologies Ltd. Enriched nanostructure composition
US20090130756A1 (en) * 2007-11-20 2009-05-21 Pioneer Surgical Orthobiologics,Inc. Cryopreservation of cells using cross-linked bioactive hydrogel matrix particles
CN101618235A (zh) * 2008-07-01 2010-01-06 中国人民解放军军事医学科学院基础医学研究所 一种基于opf水凝胶为液态支架的可注射性心肌组织工程产品
EP2341953B1 (en) * 2008-09-04 2018-11-21 The General Hospital Corporation Hydrogels for vocal cord and soft tissue augmentation and repair
US20100092533A1 (en) * 2008-10-15 2010-04-15 Joshua Stopek Bioabsorbable Surgical Composition
EP2221362A1 (en) * 2009-02-19 2010-08-25 Naturin GmbH & Co Method for the cryopreservation of cells, artificial cell constructs or three-dimensional complex tissues assemblies

Also Published As

Publication number Publication date
JP2013526297A (ja) 2013-06-24
NZ630598A (en) 2016-02-26
AR081906A1 (es) 2012-10-31
AU2011247984A1 (en) 2013-01-10
KR102493613B1 (ko) 2023-01-31
JP6987811B2 (ja) 2022-01-05
JP7358441B2 (ja) 2023-10-10
TW201202424A (en) 2012-01-16
KR20190012279A (ko) 2019-02-08
MX2012012836A (es) 2013-04-03
TW201823452A (zh) 2018-07-01
KR102230864B1 (ko) 2021-03-23
CR20120603A (es) 2013-05-15
JP6891010B2 (ja) 2021-06-18
US20110274666A1 (en) 2011-11-10
AU2011247984B2 (en) 2015-04-30
SG10201503582YA (en) 2015-06-29
JP2022022305A (ja) 2022-02-03
IL222857A0 (en) 2012-12-31
BR112012028265A2 (pt) 2016-11-01
SG185425A1 (en) 2012-12-28
IL222857A (en) 2016-05-31
CL2012003085A1 (es) 2014-01-10
IL245535A0 (en) 2016-06-30
MX2020002474A (es) 2020-07-20
JP2019178155A (ja) 2019-10-17
KR20190128754A (ko) 2019-11-18
RU2736955C2 (ru) 2020-11-23
TW202006136A (zh) 2020-02-01
RU2012152610A (ru) 2014-06-20
CA2798458A1 (en) 2011-11-10
CN111281890A (zh) 2020-06-16
WO2011140428A1 (en) 2011-11-10
MX2019009549A (es) 2019-10-02
KR20130108996A (ko) 2013-10-07
MX359678B (es) 2018-10-05
JP2017131682A (ja) 2017-08-03
RU2015155133A3 (OSRAM) 2019-05-28
IL245535B (en) 2020-09-30
EP2566567A1 (en) 2013-03-13
KR20210100748A (ko) 2021-08-17
KR102289168B1 (ko) 2021-08-11
NZ603913A (en) 2015-09-25
IL277184A (en) 2020-10-29
RU2015155133A (ru) 2019-01-16
CA2798458C (en) 2022-04-19
CN102985130A (zh) 2013-03-20
EP2566567A4 (en) 2014-11-26
PH12012502176A1 (en) 2013-02-04
BR112012028265B1 (pt) 2021-09-21
TWI687518B (zh) 2020-03-11
JP6177687B2 (ja) 2017-08-09

Similar Documents

Publication Publication Date Title
CA2798458C (en) Method of engrafting cells from solid tissues
EP2970879B1 (en) Method of treating liver conditions by transplantation of stem cells into bile duct walls
AU2019271995B2 (en) Method of engrafting cells from solid tissues
RU2574364C2 (ru) Способ трансплантации клеток из плотных тканей
BR122021002798B1 (pt) Método de criopreservação de células

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20220127

EEER Examination request

Effective date: 20220127

EEER Examination request

Effective date: 20220127

EEER Examination request

Effective date: 20220127

EEER Examination request

Effective date: 20220127

EEER Examination request

Effective date: 20220127

EEER Examination request

Effective date: 20220127

EEER Examination request

Effective date: 20220127

EEER Examination request

Effective date: 20220127

EEER Examination request

Effective date: 20220127

EEER Examination request

Effective date: 20220127

EEER Examination request

Effective date: 20220127