CA3119343C - Substituted isoindolinones - Google Patents

Substituted isoindolinones Download PDF

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Publication number
CA3119343C
CA3119343C CA3119343A CA3119343A CA3119343C CA 3119343 C CA3119343 C CA 3119343C CA 3119343 A CA3119343 A CA 3119343A CA 3119343 A CA3119343 A CA 3119343A CA 3119343 C CA3119343 C CA 3119343C
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CA
Canada
Prior art keywords
compound
optionally substituted
alkyl
cancer
hydrogen
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Active
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CA3119343A
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English (en)
French (fr)
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CA3119343A1 (en
Inventor
Kyle W. H. Chan
Aparajita Hoskote Chourasia
Paul E. Erdman
Leah Fung
Imelda LAM
Frank Mercurio
Robert Sullivan
Eduardo Torres
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BioTheryX Inc
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BioTheryX Inc
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Publication of CA3119343A1 publication Critical patent/CA3119343A1/en
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Publication of CA3119343C publication Critical patent/CA3119343C/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3119343A 2018-11-13 2019-11-12 Substituted isoindolinones Active CA3119343C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862760813P 2018-11-13 2018-11-13
US62/760,813 2018-11-13
PCT/US2019/060920 WO2020102195A1 (en) 2018-11-13 2019-11-12 Substituted isoindolinones

Publications (2)

Publication Number Publication Date
CA3119343A1 CA3119343A1 (en) 2020-05-22
CA3119343C true CA3119343C (en) 2024-01-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA3119343A Active CA3119343C (en) 2018-11-13 2019-11-12 Substituted isoindolinones

Country Status (9)

Country Link
US (2) US10844039B2 (https=)
EP (1) EP3880669A1 (https=)
JP (1) JP2022507267A (https=)
CN (1) CN113423701A (https=)
AU (1) AU2019381688A1 (https=)
CA (1) CA3119343C (https=)
IL (1) IL283057A (https=)
TW (1) TW202031641A (https=)
WO (1) WO2020102195A1 (https=)

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TW202140441A (zh) 2020-03-23 2021-11-01 美商必治妥美雅史谷比公司 經取代之側氧基異吲哚啉化合物
US20240025863A1 (en) 2020-09-16 2024-01-25 Biotheryx, Inc. Sos1 protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
WO2022087335A1 (en) 2020-10-23 2022-04-28 Biotheryx, Inc. Kras protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
CN117203196A (zh) 2020-12-14 2023-12-08 拜欧斯瑞克斯公司 Pde4降解剂、药物组合物和治疗应用
AU2022207648A1 (en) 2021-01-13 2023-07-27 Monte Rosa Therapeutics Ag Isoindolinone compounds
EP4320112B1 (en) * 2021-04-06 2025-05-14 Bristol-Myers Squibb Company Pyridinyl substituted oxoisoindoline compounds
CA3221549A1 (en) * 2021-06-08 2022-12-15 Liqiang Fu Isoindolinone compounds, and uses thereof
US12419962B2 (en) 2022-03-16 2025-09-23 Biotheryx, Inc. Quinazolines, pharmaceutical compositions, and therapeutic applications
EP4540241A1 (en) * 2022-06-16 2025-04-23 Monte Rosa Therapeutics AG Substituted piperidines as ck1a degraders
JP2025541841A (ja) * 2022-12-07 2025-12-23 ハンジョウ グルバイオ ファーマシューティカル カンパニー リミテッド オキソイソインドール－５－カルボキサミド系化合物またはその塩、溶媒和物の結晶形または無定形
PL249026B1 (pl) * 2022-12-09 2026-02-23 Univ Mikolaja Kopernika W Toruniu Pochodna azetydyno-2,4-dionu, sposób jej otrzymywania i zastosowanie
CN120097964A (zh) * 2023-12-05 2025-06-06 珠海宇繁生物科技有限责任公司 一种ikzf1降解剂及其制备方法和应用
WO2025221826A1 (en) * 2024-04-17 2025-10-23 Bristol-Myers Squibb Company Compounds for the degradation of alk proteins

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Publication number Publication date
WO2020102195A1 (en) 2020-05-22
AU2019381688A1 (en) 2021-06-03
CA3119343A1 (en) 2020-05-22
CN113423701A (zh) 2021-09-21
US20200325114A1 (en) 2020-10-15
US11352338B2 (en) 2022-06-07
IL283057A (en) 2021-06-30
JP2022507267A (ja) 2022-01-18
TW202031641A (zh) 2020-09-01
US20200148663A1 (en) 2020-05-14
EP3880669A1 (en) 2021-09-22
US10844039B2 (en) 2020-11-24

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