CA3101641A1 - Muc16 specific chimeric antigen receptors and uses thereof - Google Patents

Muc16 specific chimeric antigen receptors and uses thereof Download PDF

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Publication number
CA3101641A1
CA3101641A1 CA3101641A CA3101641A CA3101641A1 CA 3101641 A1 CA3101641 A1 CA 3101641A1 CA 3101641 A CA3101641 A CA 3101641A CA 3101641 A CA3101641 A CA 3101641A CA 3101641 A1 CA3101641 A1 CA 3101641A1
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Prior art keywords
cells
seq
car
vector
cell
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CA3101641A
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English (en)
French (fr)
Inventor
Helen SABZEVARI
Rutul R. SHAH
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Precigen Inc
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Intrexon Corp
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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CA3101641A 2018-06-04 2019-06-04 Muc16 specific chimeric antigen receptors and uses thereof Pending CA3101641A1 (en)

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Application Number Priority Date Filing Date Title
US201862680297P 2018-06-04 2018-06-04
US62/680,297 2018-06-04
PCT/US2019/035384 WO2019236577A2 (en) 2018-06-04 2019-06-04 Muc16 specific chimeric antigen receptors and uses thereof

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CA3101641A1 true CA3101641A1 (en) 2019-12-12

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US (4) US11319380B2 (enExample)
EP (1) EP3802615A4 (enExample)
JP (2) JP2021525534A (enExample)
KR (1) KR20210021493A (enExample)
AU (1) AU2019282620A1 (enExample)
CA (1) CA3101641A1 (enExample)
IL (1) IL278976A (enExample)
SG (1) SG11202011895VA (enExample)
WO (1) WO2019236577A2 (enExample)
ZA (3) ZA202008065B (enExample)

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US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
JP2021500882A (ja) * 2017-10-18 2021-01-14 プレシゲン，インコーポレイテッド スペーサーを含むポリペプチド組成物
AU2019372673A1 (en) * 2018-11-01 2021-05-27 Gracell Biotechnologies (Shanghai) Co., Ltd. Compositions and methods for T cell engineering
AU2020345943A1 (en) 2019-09-10 2022-03-31 Obsidian Therapeutics, Inc. CA2-IL15 fusion proteins for tunable regulation
EP4170020A4 (en) * 2020-06-17 2025-01-22 Kyoto University IMMUNOCOMPETENT CELLS WITH CHIMERIC ANTIGEN RECEPTOR EXPRESSION
WO2022140388A1 (en) * 2020-12-21 2022-06-30 Allogene Therapeutics, Inc. Protease-activating cd45-gate car
TW202233662A (zh) * 2020-12-31 2022-09-01 大陸商亘喜生物科技（上海）有限公司 膜融合蛋白及其在免疫細胞中的應用
WO2022159939A1 (en) * 2021-01-19 2022-07-28 Obsidian Therapeutics, Inc. Tumor-infiltrating lymphocytes with membrane bound interleukin 15 and uses thereof
WO2023150562A1 (en) * 2022-02-01 2023-08-10 Alaunos Therapeutics, Inc. Methods for activation and expansion of t cells
CN115819613B (zh) * 2022-05-10 2023-10-20 四川大学华西医院 基于msln前体蛋白构建的嵌合抗原受体免疫细胞制备及其应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004005470A2 (en) 2002-07-03 2004-01-15 Immunogen, Inc. Antibodies to non-shed muc1 and muc16, and uses thereof
NZ563370A (en) 2005-06-20 2010-10-29 Genentech Inc Compositions and methods for the diagnosis and treatment of tumor
CL2008001334A1 (es) 2007-05-08 2008-09-22 Genentech Inc Anticuerpo anti-muc16 disenado con cisteina; conjugado que lo comprende; metodo de produccion; formulacion farmaceutica que lo comprende; y su uso para tratar el cancer.
CN101918555B (zh) 2008-01-11 2013-11-06 株式会社遗传科技 人源化抗整联蛋白α9抗体及其应用
PT2496698T (pt) * 2009-11-03 2019-04-18 Hope City Recetor de fator de crescimento epidermal truncado (egfrt) para seleção de células t transduzidas
CA3002192C (en) * 2010-03-26 2023-03-07 Memorial Sloan-Kettering Cancer Center Antibodies to muc16 and methods of use thereof
EP3789487A1 (en) 2013-04-03 2021-03-10 Memorial Sloan Kettering Cancer Center Effective generation of tumor-targeted t-cells derived from pluripotent stem cells
CN112795594B (zh) * 2013-05-14 2025-09-19 得克萨斯州大学系统董事会 工程化嵌合抗原受体(car)t细胞的人应用
CA2944528C (en) * 2014-04-03 2021-08-10 Cellectis Cd33 specific chimeric antigen receptors for cancer immunotherapy
MX2017001011A (es) 2014-07-21 2018-05-28 Novartis Ag Tratamiento de cancer de usando un receptor quimerico de antigeno anti-bcma.
CA2981142A1 (en) 2015-03-27 2016-10-06 University Of Southern California Car t-cell therapy directed to lhr for the treatment of solid tumors
WO2016205176A1 (en) 2015-06-15 2016-12-22 Genentech, Inc. Antibodies and immunoconjugates
AU2016316033B2 (en) 2015-09-04 2022-03-03 Memorial Sloan Kettering Cancer Center Immune cell compositions and methods of use
KR102584300B1 (ko) * 2016-03-29 2023-10-05 유니버시티 오브 써던 캘리포니아 암을 표적하는 키메라 항원 수용체
WO2017214333A1 (en) 2016-06-08 2017-12-14 Intrexon Corporation Cd33 specific chimeric antigen receptors
TW202434291A (zh) * 2016-07-08 2024-09-01 美商建南德克公司 人類副睪蛋白4 (he4)用於評定癌症治療反應性之用途
CN110087672A (zh) 2016-07-29 2019-08-02 朱诺治疗学股份有限公司 免疫调节多肽及相关组合物和方法
CN110139674B (zh) * 2016-10-05 2023-05-16 豪夫迈·罗氏有限公司 制备抗体药物缀合物的方法
CN107557336B (zh) * 2017-09-15 2020-02-14 山东兴瑞生物科技有限公司 一种抗muc16安全型嵌合抗原受体修饰的免疫细胞及其应用

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