CA3101641A1 - Muc16 specific chimeric antigen receptors and uses thereof - Google Patents

Muc16 specific chimeric antigen receptors and uses thereof Download PDF

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Publication number
CA3101641A1
CA3101641A1 CA3101641A CA3101641A CA3101641A1 CA 3101641 A1 CA3101641 A1 CA 3101641A1 CA 3101641 A CA3101641 A CA 3101641A CA 3101641 A CA3101641 A CA 3101641A CA 3101641 A1 CA3101641 A1 CA 3101641A1
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Prior art keywords
cells
seq
car
vector
cell
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CA3101641A
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English (en)
French (fr)
Inventor
Helen SABZEVARI
Rutul R. SHAH
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Precigen Inc
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Intrexon Corp
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Publication of CA3101641A1 publication Critical patent/CA3101641A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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CA3101641A 2018-06-04 2019-06-04 Muc16 specific chimeric antigen receptors and uses thereof Pending CA3101641A1 (en)

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Application Number Priority Date Filing Date Title
US201862680297P 2018-06-04 2018-06-04
US62/680,297 2018-06-04
PCT/US2019/035384 WO2019236577A2 (en) 2018-06-04 2019-06-04 Muc16 specific chimeric antigen receptors and uses thereof

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CA3101641A1 true CA3101641A1 (en) 2019-12-12

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US (4) US11319380B2 (enExample)
EP (1) EP3802615A4 (enExample)
JP (3) JP2021525534A (enExample)
KR (1) KR102974340B1 (enExample)
CN (2) CN112533957B (enExample)
AU (1) AU2019282620B2 (enExample)
CA (1) CA3101641A1 (enExample)
IL (1) IL278976A (enExample)
SG (1) SG11202011895VA (enExample)
WO (1) WO2019236577A2 (enExample)
ZA (3) ZA202008065B (enExample)

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US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
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