CA3101641A1 - Muc16 specific chimeric antigen receptors and uses thereof - Google Patents

Muc16 specific chimeric antigen receptors and uses thereof Download PDF

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Publication number
CA3101641A1
CA3101641A1 CA3101641A CA3101641A CA3101641A1 CA 3101641 A1 CA3101641 A1 CA 3101641A1 CA 3101641 A CA3101641 A CA 3101641A CA 3101641 A CA3101641 A CA 3101641A CA 3101641 A1 CA3101641 A1 CA 3101641A1
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Prior art keywords
cells
seq
car
vector
cell
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CA3101641A
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English (en)
French (fr)
Inventor
Helen SABZEVARI
Rutul R. SHAH
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Precigen Inc
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Intrexon Corp
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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CA3101641A 2018-06-04 2019-06-04 Muc16 specific chimeric antigen receptors and uses thereof Pending CA3101641A1 (en)

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Application Number Priority Date Filing Date Title
US201862680297P 2018-06-04 2018-06-04
US62/680,297 2018-06-04
PCT/US2019/035384 WO2019236577A2 (en) 2018-06-04 2019-06-04 Muc16 specific chimeric antigen receptors and uses thereof

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CA3101641A1 true CA3101641A1 (en) 2019-12-12

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CA3101641A Pending CA3101641A1 (en) 2018-06-04 2019-06-04 Muc16 specific chimeric antigen receptors and uses thereof

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US (4) US11319380B2 (enExample)
EP (1) EP3802615A4 (enExample)
JP (3) JP2021525534A (enExample)
KR (1) KR20210021493A (enExample)
CN (2) CN112533957B (enExample)
AU (1) AU2019282620B2 (enExample)
CA (1) CA3101641A1 (enExample)
IL (1) IL278976A (enExample)
SG (1) SG11202011895VA (enExample)
WO (1) WO2019236577A2 (enExample)
ZA (3) ZA202008065B (enExample)

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US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
IL273961B2 (en) * 2017-10-18 2025-04-01 Precigen Inc Polypeptide compositions containing spacers
WO2020088631A1 (en) * 2018-11-01 2020-05-07 Gracell Biotechnologies (Shanghai) Co., Ltd. Compositions and methods for t cell engineering
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