CA3096199A1 - Metallo-liothyronine - Google Patents
Metallo-liothyronine Download PDFInfo
- Publication number
- CA3096199A1 CA3096199A1 CA3096199A CA3096199A CA3096199A1 CA 3096199 A1 CA3096199 A1 CA 3096199A1 CA 3096199 A CA3096199 A CA 3096199A CA 3096199 A CA3096199 A CA 3096199A CA 3096199 A1 CA3096199 A1 CA 3096199A1
- Authority
- CA
- Canada
- Prior art keywords
- complex
- metal
- biologically active
- active moiety
- another embodiment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic Table without C-Metal linkages
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862652705P | 2018-04-04 | 2018-04-04 | |
| US62/652,705 | 2018-04-04 | ||
| PCT/US2019/025725 WO2019195513A1 (en) | 2018-04-04 | 2019-04-04 | Metallo-liothyronine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3096199A1 true CA3096199A1 (en) | 2019-10-10 |
Family
ID=68101148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3096199A Pending CA3096199A1 (en) | 2018-04-04 | 2019-04-04 | Metallo-liothyronine |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11712426B2 (https=) |
| EP (1) | EP3773733B1 (https=) |
| JP (1) | JP7535993B2 (https=) |
| KR (1) | KR20200143701A (https=) |
| CN (1) | CN112218661A (https=) |
| AU (1) | AU2019247217A1 (https=) |
| BR (1) | BR112020020403A8 (https=) |
| CA (1) | CA3096199A1 (https=) |
| WO (1) | WO2019195513A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11712426B2 (en) * | 2018-04-04 | 2023-08-01 | Synthonics, Inc. | Metallo-liothyronine |
| JP2022030705A (ja) * | 2020-08-07 | 2022-02-18 | 日本曹達株式会社 | チアベンダゾール含有配位高分子 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1298613B1 (it) * | 1998-03-10 | 2000-01-12 | Bracco Spa | Chelati complessi di manganese ad alta relassivita' in siero |
| JP2003261683A (ja) * | 2002-03-06 | 2003-09-19 | Nof Corp | 中性（ベンゼン−１，２，４，５−テトラチオラート）金属錯体ポリマー、その製造方法および用途 |
| US20060141054A1 (en) | 2004-10-25 | 2006-06-29 | Thomas Piccariello | Metal coordinated compositions |
| US7799937B2 (en) | 2004-10-25 | 2010-09-21 | Synthonics, Inc. | Metal coordinated compositions |
| AU2013205471B2 (en) | 2005-10-24 | 2016-02-11 | Synthonics, Inc. | Metal coordinated compositions |
| JP5162758B2 (ja) * | 2006-03-02 | 2013-03-13 | 大学共同利用機関法人自然科学研究機構 | マイクロチャンネルリアクター |
| EP2536408A1 (en) * | 2010-02-16 | 2012-12-26 | Wockhardt Research Centre | Efflux pump inhibitors |
| US10150792B2 (en) * | 2010-11-08 | 2018-12-11 | Synthonics, Inc. | Bismuth-containing compounds, coordination polymers, methods for modulating pharmacokinetic properties of biologically active agents, and methods for treating patients |
| JP6183763B2 (ja) * | 2014-05-02 | 2017-08-23 | 国立研究開発法人物質・材料研究機構 | 有機／ヘテロ金属ハイブリットポリマー、その合成方法、有機／ヘテロ金属ハイブリットポリマーの膜、有機／マルチ金属ハイブリットポリマー、その合成方法、及び有機／マルチ金属ハイブリットポリマーの膜 |
| CA2951923A1 (en) * | 2014-06-18 | 2015-12-23 | Thetis Pharmaceuticals Llc | Mineral amino-acid complexes of active agents |
| JP6838268B2 (ja) * | 2015-10-21 | 2021-03-03 | コニカミノルタ株式会社 | 光変換材料、光変換フィルム、及び発光素子 |
| US11712426B2 (en) * | 2018-04-04 | 2023-08-01 | Synthonics, Inc. | Metallo-liothyronine |
-
2019
- 2019-04-04 US US17/045,234 patent/US11712426B2/en active Active
- 2019-04-04 WO PCT/US2019/025725 patent/WO2019195513A1/en not_active Ceased
- 2019-04-04 KR KR1020207031803A patent/KR20200143701A/ko not_active Ceased
- 2019-04-04 CA CA3096199A patent/CA3096199A1/en active Pending
- 2019-04-04 BR BR112020020403A patent/BR112020020403A8/pt unknown
- 2019-04-04 CN CN201980028465.9A patent/CN112218661A/zh active Pending
- 2019-04-04 EP EP19781565.7A patent/EP3773733B1/en active Active
- 2019-04-04 AU AU2019247217A patent/AU2019247217A1/en not_active Abandoned
- 2019-04-04 JP JP2021503706A patent/JP7535993B2/ja active Active
-
2023
- 2023-07-31 US US18/362,813 patent/US20230381126A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP7535993B2 (ja) | 2024-08-19 |
| EP3773733A4 (en) | 2022-05-25 |
| US20230381126A1 (en) | 2023-11-30 |
| EP3773733A1 (en) | 2021-02-17 |
| US11712426B2 (en) | 2023-08-01 |
| AU2019247217A1 (en) | 2020-11-26 |
| EP3773733C0 (en) | 2025-11-12 |
| BR112020020403A8 (pt) | 2021-04-13 |
| EP3773733B1 (en) | 2025-11-12 |
| KR20200143701A (ko) | 2020-12-24 |
| BR112020020403A2 (pt) | 2021-03-23 |
| JP2021521268A (ja) | 2021-08-26 |
| CN112218661A (zh) | 2021-01-12 |
| US20210046032A1 (en) | 2021-02-18 |
| WO2019195513A1 (en) | 2019-10-10 |
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Free format text: ST27 STATUS EVENT CODE: N-2-6-B10-B12-B303 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DEEMED ABANDONED - FAILURE TO RESPOND TO AN EXAMINER'S REQUISITION Effective date: 20250905 |
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| U00 | Fee paid |
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