CA3083941A1 - Il-2 muteins and uses thereof - Google Patents
Il-2 muteins and uses thereof Download PDFInfo
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- CA3083941A1 CA3083941A1 CA3083941A CA3083941A CA3083941A1 CA 3083941 A1 CA3083941 A1 CA 3083941A1 CA 3083941 A CA3083941 A CA 3083941A CA 3083941 A CA3083941 A CA 3083941A CA 3083941 A1 CA3083941 A1 CA 3083941A1
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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- A—HUMAN NECESSITIES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
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- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Rheumatology (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (11)
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| US201762595357P | 2017-12-06 | 2017-12-06 | |
| US62/595,357 | 2017-12-06 | ||
| US201862675972P | 2018-05-24 | 2018-05-24 | |
| US62/675,972 | 2018-05-24 | ||
| US201862721644P | 2018-08-23 | 2018-08-23 | |
| US16/109,897 US10174092B1 (en) | 2017-12-06 | 2018-08-23 | IL-2 muteins |
| US16/109,897 | 2018-08-23 | ||
| US16/109,875 US10174091B1 (en) | 2017-12-06 | 2018-08-23 | IL-2 muteins |
| US16/109,875 | 2018-08-23 | ||
| US62/721,644 | 2018-08-23 | ||
| PCT/US2018/062808 WO2019112854A1 (en) | 2017-12-06 | 2018-11-28 | Il-2 muteins and uses thereof |
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| CA3083941A1 true CA3083941A1 (en) | 2019-06-13 |
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| EP (1) | EP3720470A4 (de) |
| JP (1) | JP7250790B2 (de) |
| KR (1) | KR20200097275A (de) |
| CN (1) | CN111432831A (de) |
| AU (1) | AU2018378078A1 (de) |
| BR (1) | BR112020011343A2 (de) |
| CA (1) | CA3083941A1 (de) |
| IL (1) | IL274844A (de) |
| MX (1) | MX2020005208A (de) |
| SG (1) | SG11202003965VA (de) |
| WO (1) | WO2019112854A1 (de) |
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| EP3596108A4 (de) | 2017-03-15 | 2020-12-23 | Pandion Operations, Inc. | Gezielte immuntoleranz |
| JP2020521452A (ja) | 2017-05-24 | 2020-07-27 | パンディオン・セラピューティクス・インコーポレイテッド | 標的化免疫寛容 |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| JP2022533702A (ja) | 2019-05-20 | 2022-07-25 | パンディオン・オペレーションズ・インコーポレイテッド | ＭＡｄＣＡＭ標的化免疫寛容 |
| KR20220050168A (ko) * | 2019-08-19 | 2022-04-22 | 팬디온 오퍼레이션스, 인코포레이티드 | Pd-1 작용제로 표적된 면역관용 |
| CN110642934B (zh) * | 2019-09-10 | 2022-08-23 | 中国医学科学院北京协和医院 | 靶向调节t细胞的长效白介素-2及其在治疗自身免疫病中的应用 |
| JP2022552371A (ja) | 2019-10-15 | 2022-12-15 | モデルナティエックス インコーポレイテッド | 免疫調節ポリペプチドをコードするｍＲＮＡ及びその使用 |
| US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
| CN112358540A (zh) * | 2020-11-03 | 2021-02-12 | 安徽环球基因科技有限公司 | 一种重组il2在毕赤酵母中的生产方法 |
| WO2023165553A1 (zh) * | 2022-03-03 | 2023-09-07 | 海南先声药业有限公司 | IL2突变体-抗体Fc嵌段融合蛋白的药物组合物及其应用 |
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| CN1007907B (zh) * | 1985-04-30 | 1990-05-09 | 弗·哈夫曼-拉罗彻有限公司 | 重组人类白细胞介素-2的提纯 |
| US7569215B2 (en) | 2003-07-18 | 2009-08-04 | Massachusetts Institute Of Technology | Mutant interleukin-2 (IL-2) polypeptides |
| EP2655409A4 (de) * | 2010-12-22 | 2015-07-01 | Univ Leland Stanford Junior | Superagonisten und antagonisten von interleukin-2 |
| US20140170153A1 (en) * | 2011-05-31 | 2014-06-19 | Novo Nordisk A/S | Il-21 epitope and il-21 ligands |
| US9546203B2 (en) | 2013-03-14 | 2017-01-17 | Amgen Inc. | Aglycosylated Fc-containing polypeptides with cysteine substitutions |
| IL289475B2 (en) * | 2014-07-21 | 2023-10-01 | Delinia Inc | Molecules that activate T cells are selectively regulated for the treatment of autoimmune diseases |
| CN109071623B (zh) * | 2016-05-04 | 2022-05-27 | 美国安进公司 | 用于扩增t调节性细胞的白细胞介素-2突变蛋白 |
| EP3606947B1 (de) * | 2017-04-03 | 2022-12-21 | F. Hoffmann-La Roche AG | Immunokonjugat von il-2 mit einem bispezifischen antikörper gerichtet gegen pd-1 und tim-3 |
| WO2019112852A1 (en) | 2017-12-06 | 2019-06-13 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
| JP2020521452A (ja) | 2017-05-24 | 2020-07-27 | パンディオン・セラピューティクス・インコーポレイテッド | 標的化免疫寛容 |
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| IL274844A (en) | 2020-07-30 |
| CN111432831A (zh) | 2020-07-17 |
| AU2018378078A1 (en) | 2020-06-18 |
| WO2019112854A1 (en) | 2019-06-13 |
| MX2020005208A (es) | 2020-08-20 |
| JP7250790B2 (ja) | 2023-04-03 |
| KR20200097275A (ko) | 2020-08-18 |
| SG11202003965VA (en) | 2020-06-29 |
| KR20240039201A (ko) | 2024-03-26 |
| JP2021507690A (ja) | 2021-02-25 |
| EP3720470A4 (de) | 2021-09-15 |
| EP3720470A1 (de) | 2020-10-14 |
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