IL274844A - IL-2 mutants and their uses - Google Patents
IL-2 mutants and their usesInfo
- Publication number
- IL274844A IL274844A IL274844A IL27484420A IL274844A IL 274844 A IL274844 A IL 274844A IL 274844 A IL274844 A IL 274844A IL 27484420 A IL27484420 A IL 27484420A IL 274844 A IL274844 A IL 274844A
- Authority
- IL
- Israel
- Prior art keywords
- muteins
- Prior art date
Links
- 101150083678 IL2 gene Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762595357P | 2017-12-06 | 2017-12-06 | |
| US201862675972P | 2018-05-24 | 2018-05-24 | |
| US201862721644P | 2018-08-23 | 2018-08-23 | |
| US16/109,897 US10174092B1 (en) | 2017-12-06 | 2018-08-23 | IL-2 muteins |
| US16/109,875 US10174091B1 (en) | 2017-12-06 | 2018-08-23 | IL-2 muteins |
| PCT/US2018/062808 WO2019112854A1 (en) | 2017-12-06 | 2018-11-28 | Il-2 muteins and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL274844A true IL274844A (en) | 2020-07-30 |
Family
ID=66751187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL274844A IL274844A (en) | 2017-12-06 | 2020-05-21 | IL-2 mutants and their uses |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP3720470A4 (de) |
| JP (1) | JP7250790B2 (de) |
| KR (2) | KR20200097275A (de) |
| CN (1) | CN111432831A (de) |
| AU (1) | AU2018378078A1 (de) |
| BR (1) | BR112020011343A2 (de) |
| CA (1) | CA3083941A1 (de) |
| IL (1) | IL274844A (de) |
| MX (1) | MX2020005208A (de) |
| SG (1) | SG11202003965VA (de) |
| WO (1) | WO2019112854A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018234810B2 (en) | 2017-03-15 | 2023-05-11 | Pandion Operations, Inc. | Targeted immunotolerance |
| SG11201909949XA (en) | 2017-05-24 | 2019-11-28 | Pandion Therapeutics Inc | Targeted immunotolerance |
| US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| TW202110885A (zh) | 2019-05-20 | 2021-03-16 | 美商潘迪恩治療公司 | 靶向ＭＡｄＣＡＭ之免疫耐受性 |
| CN114728179A (zh) * | 2019-08-19 | 2022-07-08 | 潘迪恩运营公司 | 利用pd-1激动剂的靶向免疫耐受 |
| CN114853874B (zh) * | 2019-09-10 | 2024-05-17 | 中国医学科学院北京协和医院 | 靶向调节t细胞的长效白介素-2及其在治疗自身免疫病中的应用 |
| US20240158458A1 (en) | 2019-10-15 | 2024-05-16 | Moderna TX, Inc. | Mrnas encoding immune modulating polypeptides and uses thereof |
| EP4107187A1 (de) | 2020-02-21 | 2022-12-28 | Pandion Operations, Inc. | Gewebegezielte immuntoleranz mit einem cd39-effektor |
| CN112358540A (zh) * | 2020-11-03 | 2021-02-12 | 安徽环球基因科技有限公司 | 一种重组il2在毕赤酵母中的生产方法 |
| WO2023165553A1 (zh) * | 2022-03-03 | 2023-09-07 | 海南先声药业有限公司 | IL2突变体-抗体Fc嵌段融合蛋白的药物组合物及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1007907B (zh) * | 1985-04-30 | 1990-05-09 | 弗·哈夫曼-拉罗彻有限公司 | 重组人类白细胞介素-2的提纯 |
| US7569215B2 (en) | 2003-07-18 | 2009-08-04 | Massachusetts Institute Of Technology | Mutant interleukin-2 (IL-2) polypeptides |
| EP3211001B1 (de) * | 2010-12-22 | 2020-10-07 | The Board of Trustees of the Leland Stanford Junior University | Superagonisten und antagonisten von interleukin-2 |
| EP2714198A1 (de) * | 2011-05-31 | 2014-04-09 | Novo Nordisk A/S | Il-21-epitope und il-21-liganden |
| US9580486B2 (en) * | 2013-03-14 | 2017-02-28 | Amgen Inc. | Interleukin-2 muteins for the expansion of T-regulatory cells |
| EP3587444A1 (de) * | 2014-07-21 | 2020-01-01 | Delinia, Inc. | Moleküle zur selektiven aktivierung regulatorischer t-zellen zur behandlung von autoimmunerkrankungen |
| JP7422480B2 (ja) * | 2016-05-04 | 2024-01-26 | アムジエン・インコーポレーテツド | 制御性ｔ細胞の増殖のためのインターロイキン－２変異タンパク質 |
| WO2018184965A1 (en) * | 2017-04-03 | 2018-10-11 | F. Hoffmann-La Roche Ag | Immunoconjugates of il-2 with an anti-pd-1 and tim-3 bispecific antibody |
| SG11201909949XA (en) * | 2017-05-24 | 2019-11-28 | Pandion Therapeutics Inc | Targeted immunotolerance |
| EP3720871A4 (de) | 2017-12-06 | 2021-09-15 | Pandion Operations, Inc. | Gezielte immuntoleranz |
-
2018
- 2018-11-28 KR KR1020207017255A patent/KR20200097275A/ko not_active Application Discontinuation
- 2018-11-28 JP JP2020530653A patent/JP7250790B2/ja active Active
- 2018-11-28 EP EP18887098.4A patent/EP3720470A4/de active Pending
- 2018-11-28 AU AU2018378078A patent/AU2018378078A1/en active Pending
- 2018-11-28 SG SG11202003965VA patent/SG11202003965VA/en unknown
- 2018-11-28 CA CA3083941A patent/CA3083941A1/en active Pending
- 2018-11-28 WO PCT/US2018/062808 patent/WO2019112854A1/en unknown
- 2018-11-28 KR KR1020247008135A patent/KR20240039201A/ko active Application Filing
- 2018-11-28 CN CN201880077653.6A patent/CN111432831A/zh active Pending
- 2018-11-28 BR BR112020011343-3A patent/BR112020011343A2/pt unknown
- 2018-11-28 MX MX2020005208A patent/MX2020005208A/es unknown
-
2020
- 2020-05-21 IL IL274844A patent/IL274844A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG11202003965VA (en) | 2020-06-29 |
| CN111432831A (zh) | 2020-07-17 |
| KR20240039201A (ko) | 2024-03-26 |
| EP3720470A4 (de) | 2021-09-15 |
| MX2020005208A (es) | 2020-08-20 |
| WO2019112854A1 (en) | 2019-06-13 |
| AU2018378078A1 (en) | 2020-06-18 |
| KR20200097275A (ko) | 2020-08-18 |
| CA3083941A1 (en) | 2019-06-13 |
| JP7250790B2 (ja) | 2023-04-03 |
| JP2021507690A (ja) | 2021-02-25 |
| EP3720470A1 (de) | 2020-10-14 |
| BR112020011343A2 (pt) | 2020-11-17 |
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