CA3078739A1 - Traitement de la demence par stimulation visuelle pour induire des oscillations gama synchronisees dans le cerveau - Google Patents

Traitement de la demence par stimulation visuelle pour induire des oscillations gama synchronisees dans le cerveau

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Publication number
CA3078739A1
CA3078739A1 CA3078739A CA3078739A CA3078739A1 CA 3078739 A1 CA3078739 A1 CA 3078739A1 CA 3078739 A CA3078739 A CA 3078739A CA 3078739 A CA3078739 A CA 3078739A CA 3078739 A1 CA3078739 A1 CA 3078739A1
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Prior art keywords
subject
visual stimuli
mice
chronic
chronic visual
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CA3078739A
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English (en)
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Chinnakkaruppan Adaikkan
Li-Huei Tsai
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0618—Psychological treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0622—Optical stimulation for exciting neural tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0022—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the tactile sense, e.g. vibrations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0027—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the hearing sense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0044—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the sight sense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0626—Monitoring, verifying, controlling systems and methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A61N2005/0647—Applicators worn by the patient the applicator adapted to be worn on the head
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A61N2005/0647—Applicators worn by the patient the applicator adapted to be worn on the head
    • A61N2005/0648—Applicators worn by the patient the applicator adapted to be worn on the head the light being directed to the eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0664—Details
    • A61N2005/0667—Filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Psychology (AREA)
  • Developmental Disabilities (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Biophysics (AREA)
  • Social Psychology (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des dispositifs, des systèmes et des procédés de traitement de la démence ou de la maladie d'Alzheimer chez un sujet en ayant besoin. Selon un exemple, des stimuli visuels chroniques ayant une fréquence d'environ 30 Hz à environ 50 Hz, et plus particulièrement d'environ 40 Hz, sont administrés de manière non invasive au sujet pour entraîner des oscillations gamma dans de multiples régions cérébrales du sujet, comprenant le cortex préfrontal (PFC) et l'hippocampe. Les oscillations gamma entraînées modulent l'activité neuronale à travers de multiples régions cérébrales (par exemple, facilitent la liaison fonctionnelle de réseaux neuronaux à de basses fréquences gamma) pour induire divers effets neuroprotecteurs (par exemple, amélioration des plaques amyloïdes et de l'hyperphosphorylation de Tau) et réduire la neurodégénérescence. L'activité neuronale médiée par les stimuli visuels chroniques réduit une réponse immunitaire de la microglie et améliore les gènes et protéines modifiés de manière aberrante impliqués dans le trafic membranaire, le transport intracellulaire, la fonction synaptique, la neuro-inflammation et la réponse à l'endommagement de l'ADN. Une modification du comportement comprenant un apprentissage et une mémoire améliorés est observée.
CA3078739A 2017-10-10 2018-10-10 Traitement de la demence par stimulation visuelle pour induire des oscillations gama synchronisees dans le cerveau Pending CA3078739A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762570250P 2017-10-10 2017-10-10
US62/570,250 2017-10-10
US201762570929P 2017-10-11 2017-10-11
US62/570,929 2017-10-11
USPCT/US2018/051785 2018-09-19
PCT/US2018/055258 WO2019075094A1 (fr) 2017-10-10 2018-10-10 Traitement de la démence par stimulation visuelle pour induire des oscillations gama synchronisées dans le cerveau

Publications (1)

Publication Number Publication Date
CA3078739A1 true CA3078739A1 (fr) 2019-04-18

Family

ID=83459525

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3078739A Pending CA3078739A1 (fr) 2017-10-10 2018-10-10 Traitement de la demence par stimulation visuelle pour induire des oscillations gama synchronisees dans le cerveau

Country Status (7)

Country Link
EP (1) EP3694593A4 (fr)
JP (1) JP2020536643A (fr)
KR (2) KR20230015501A (fr)
CN (1) CN111655319A (fr)
AU (2) AU2018347366B2 (fr)
CA (1) CA3078739A1 (fr)
WO (1) WO2019075094A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114555166A (zh) 2019-10-18 2022-05-27 奥地利科学技术研究所 神经元可塑性的刺激
KR20210053631A (ko) * 2019-11-04 2021-05-12 한국과학기술원 가시광선을 이용하여 감마 대역의 뇌파를 활성화하는 방법 및 이를 위한 시각 자극 제공 장치
KR102425066B1 (ko) * 2022-03-25 2022-07-28 (주)리솔 실시간 eeg 신호 모니터링을 기초로, 뇌에서 동기화된 뇌파진동을 동조시키는 맞춤형 경두개교류전기자극 장치 및 방법
CN116407766A (zh) 2021-12-31 2023-07-11 株式会社利率 定制型经颅交流电刺激装置及方法
KR102400319B1 (ko) * 2021-12-31 2022-05-24 (주)리솔 객체의 복수의 뇌 영역에서 동기화된 진동을 동조시킴으로써, 뇌를 자극하는 장치 및 방법
KR102577515B1 (ko) 2022-11-21 2023-09-12 이종설 파동자극 생성기기

Family Cites Families (17)

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DK0618968T3 (da) * 1991-12-06 2000-04-10 Max Planck Gesellschaft Midler til diagnostisering og behandling af Alzheimer's sygdom
JP3648802B2 (ja) * 1994-09-27 2005-05-18 松下電工株式会社 光治療用高照度光照射装置
JP2008520280A (ja) * 2004-11-15 2008-06-19 デチャームス，クリストファー 光を使用した神経組織の刺激の適用
US20080181882A1 (en) * 2006-11-15 2008-07-31 The University Of Pennsylvania Neurgulin 1 (NRG1) - ErbB4 signaling as a target for the treatment of schizophrenia
KR20100039287A (ko) * 2007-05-25 2010-04-15 토마스 제퍼슨 유니버시티 집중력 및/또는 기억력의 향상이 필요한 개체에 집중력 및/또는 기억력을 향상시키는 치료방법
DE102008012669B8 (de) * 2008-03-05 2011-03-03 Anm Adaptive Neuromodulation Gmbh Vorrichtung und Verfahren zur visuellen Stimulation
ITRM20090027A1 (it) * 2009-01-26 2010-07-27 Alain Rocco Apparato di stimolazione per il trattamento del dolore e relativo metodo di funzionamento.
WO2012024243A1 (fr) * 2010-08-16 2012-02-23 Photothera, Inc. Photothérapie de faible intensité mini-invasive pour des troubles neurologiques
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WO2017172728A1 (fr) * 2016-03-28 2017-10-05 Duke University Systèmes et procédés de stimulation cérébrale

Also Published As

Publication number Publication date
KR20230015501A (ko) 2023-01-31
EP3694593A1 (fr) 2020-08-19
JP2020536643A (ja) 2020-12-17
CN111655319A (zh) 2020-09-11
AU2018347366B2 (en) 2022-09-15
AU2018347366A1 (en) 2020-04-23
WO2019075094A1 (fr) 2019-04-18
EP3694593A4 (fr) 2021-07-21
AU2022271389A1 (en) 2022-12-15
KR20200086277A (ko) 2020-07-16

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