CA3078267C - Compositions and methods of modulating the immune response by activating alpha protein kinase 1 - Google Patents

Compositions and methods of modulating the immune response by activating alpha protein kinase 1 Download PDF

Info

Publication number
CA3078267C
CA3078267C CA3078267A CA3078267A CA3078267C CA 3078267 C CA3078267 C CA 3078267C CA 3078267 A CA3078267 A CA 3078267A CA 3078267 A CA3078267 A CA 3078267A CA 3078267 C CA3078267 C CA 3078267C
Authority
CA
Canada
Prior art keywords
alpk1
agonist
compound
virus
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3078267A
Other languages
English (en)
French (fr)
Other versions
CA3078267A1 (en
Inventor
Tian Xu
Cong XU
Danyang Liu
Jieqing FAN
Yanfang PAN
Tongruei Raymond LI
Xiaodong Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Yao Yuan Biotechnology Co Ltd
Original Assignee
Shanghai Yao Yuan Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Yao Yuan Biotechnology Co Ltd filed Critical Shanghai Yao Yuan Biotechnology Co Ltd
Publication of CA3078267A1 publication Critical patent/CA3078267A1/en
Application granted granted Critical
Publication of CA3078267C publication Critical patent/CA3078267C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA3078267A 2017-10-27 2018-10-25 Compositions and methods of modulating the immune response by activating alpha protein kinase 1 Active CA3078267C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CNPCT/CN2017/107962 2017-10-27
CNPCT/CN2017/107962 2017-10-27
CNPCT/CN2018/083153 2018-04-16
CNPCT/CN2018/083153 2018-04-16
CNPCT/CN2018/100871 2018-08-16
CNPCT/CN2018/100871 2018-08-16
PCT/CN2018/111885 WO2019080898A1 (en) 2017-10-27 2018-10-25 COMPOSITIONS AND METHODS FOR MODULATION OF IMMUNE RESPONSE BY ACTIVATION OF PROTEIN KINASE ALPHA 1

Publications (2)

Publication Number Publication Date
CA3078267A1 CA3078267A1 (en) 2019-05-02
CA3078267C true CA3078267C (en) 2024-06-18

Family

ID=66246202

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3078267A Active CA3078267C (en) 2017-10-27 2018-10-25 Compositions and methods of modulating the immune response by activating alpha protein kinase 1

Country Status (8)

Country Link
US (5) US11186606B2 (https=)
EP (1) EP3700536A4 (https=)
JP (2) JP7837141B2 (https=)
KR (1) KR102733555B1 (https=)
CN (1) CN111565726A (https=)
AU (1) AU2018355487B2 (https=)
CA (1) CA3078267C (https=)
WO (1) WO2019080898A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
WO2015105955A1 (en) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
CA2990885A1 (en) 2015-06-30 2017-01-05 Sanford-Burnham Medical Research Institute Btla fusion protein agonists and uses thereof
JP7837141B2 (ja) 2017-10-27 2026-03-30 シャンハイ・ヤオ・ユアン・バイオテクノロジー・カンパニー・リミテッド αタンパク質キナーゼ１を活性化することによって免疫応答をモジュレートするための組成物および方法
KR20210020104A (ko) * 2018-06-14 2021-02-23 내셔널 인스티튜트 오브 바이올로지칼 사이언시스, 베이징 면역 반응 촉진
EP3958870A1 (en) * 2019-04-26 2022-03-02 Shanghai Yao Yuan Biotechnology Co., Ltd. Derivatives of glycero-manno-heptose adp for use in modulating immune response
WO2021231436A1 (en) * 2020-05-11 2021-11-18 The Board Of Trustees Of The Leland Stanford Junior University Therapeutic methods for treating covid-19 infections
EP4196131A1 (en) * 2020-08-14 2023-06-21 Merck Sharp & Dohme LLC Synthesis of fluorinated nucleotides
WO2022127914A1 (en) 2020-12-18 2022-06-23 Pyrotech (Beijing) Biotechnology Co., Ltd. Nucleoside-thiodiphosphate-heptose compounds for treating conditions associated with alpk1 activity
KR20240073091A (ko) * 2021-09-30 2024-05-24 파이로테크 (베이징) 바이오테크놀로지 컴퍼니, 리미티드 Alpk1 활성과 관련된 상태를 치료하기 위한 뉴클레오시드-디포스페이트-헵토스 화합물
CN115089715B (zh) * 2022-07-06 2023-06-30 四川大学 Alpk1基因作为中枢神经系统疾病预防或治疗靶点的应用
WO2025113626A2 (en) 2023-11-30 2025-06-05 Pyrotech (Beijing) Biotechnology Co., Ltd. Salt forms of alpk1 activators
CN117517657B (zh) * 2024-01-08 2024-04-09 中国农业科学院北京畜牧兽医研究所 Lnx1基因或蛋白在调控禽类先天免疫应答反应中的应用
WO2025214420A1 (zh) * 2024-04-09 2025-10-16 上海药苑生物科技有限公司 一种杂环化合物的应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE7611930U1 (de) 1976-04-15 1977-01-13 Filterwerk Mann & Hummel Gmbh, 7140 Ludwigsburg Vorrichtung zum mischen von koernigem oder pulverfoermigem material mit einem oder mehreren zusatzstoffen
NZ546058A (en) 2004-01-12 2010-09-30 Ym Biosciences Australia Pty Benzimidazole and other fused ring derivatives as selective janus kinase inhibitors
UA99434C2 (ru) * 2005-12-19 2012-08-27 Аетерна Центаріс Гмбх Применение производных алкилфосфолипидов со сниженной цитотоксичностью
WO2007119815A1 (ja) * 2006-04-14 2007-10-25 Kyowa Hakko Kirin Co., Ltd. Ｔｏｌｌ様受容体９作動薬
US20090098056A1 (en) 2007-09-10 2009-04-16 National Health Research Institute Alpk1 gene variants in diagnosis risk of gout
PL2303264T3 (pl) 2008-06-09 2018-08-31 Allergan, Inc. Sposoby leczenia stanów pośredniczonych alfa-adrenergicznie z użyciem pochodnych imidazoliny
CN201735264U (zh) 2010-05-27 2011-02-09 蓝星化工有限责任公司 一种尘降器
CN202590724U (zh) 2010-12-20 2012-12-12 西安磁林电气有限公司 一种加料装置
EP3778896A1 (en) 2011-08-09 2021-02-17 Fred Hutchinson Cancer Research Center Methods and compositions for inhibiting the growth and/or proliferation of myc-driven tumor cells
AU2013283318B2 (en) 2012-06-27 2017-11-23 4Sc Ag Bifluorodioxalane-amino-benzimidazole kinase inhibitors for the treatment of cancer, autoimmuneinflammation and CNS disorders
GB201408100D0 (en) 2014-05-07 2014-06-18 Sec Dep For Health The Detection method
CN204182373U (zh) 2014-09-30 2015-03-04 天津博弘化工有限责任公司 流化床下料斗排气装置
WO2016054745A1 (en) 2014-10-10 2016-04-14 The Governing Council Of The University Of Toronto Methods of modulating immune system responses
CN204973750U (zh) 2015-05-26 2016-01-20 柳州钢铁股份有限公司 圆筒混合机刮料器
EP3190062A1 (en) * 2016-01-07 2017-07-12 Pont Packaging B.V. A cap construction with a storage space and a container provided therewith as well as a method of using same
CN105536635A (zh) 2016-02-02 2016-05-04 珠海格力智能装备有限公司 一种车用尿素加料装置
CN206366365U (zh) 2016-12-13 2017-08-01 珠海格力智能装备有限公司 吸料装置及具有其的尿素机
CN106582336B (zh) 2016-12-13 2022-09-13 珠海格力智能装备有限公司 吸料装置及具有其的尿素机
JP7837141B2 (ja) 2017-10-27 2026-03-30 シャンハイ・ヤオ・ユアン・バイオテクノロジー・カンパニー・リミテッド αタンパク質キナーゼ１を活性化することによって免疫応答をモジュレートするための組成物および方法

Also Published As

Publication number Publication date
US20200283468A1 (en) 2020-09-10
US11840551B2 (en) 2023-12-12
US20210403501A1 (en) 2021-12-30
WO2019080898A1 (en) 2019-05-02
AU2018355487A1 (en) 2020-04-23
JP2023182695A (ja) 2023-12-26
JP2021500394A (ja) 2021-01-07
CA3078267A1 (en) 2019-05-02
EP3700536A1 (en) 2020-09-02
US11773131B2 (en) 2023-10-03
US11186606B2 (en) 2021-11-30
CN111565726A (zh) 2020-08-21
JP7837141B2 (ja) 2026-03-30
US20190367553A1 (en) 2019-12-05
US11149051B2 (en) 2021-10-19
KR102733555B1 (ko) 2024-11-25
US20220017560A1 (en) 2022-01-20
AU2018355487A2 (en) 2020-05-21
US20240124511A1 (en) 2024-04-18
AU2018355487B2 (en) 2023-09-21
KR20200090154A (ko) 2020-07-28
EP3700536A4 (en) 2021-11-17

Similar Documents

Publication Publication Date Title
CA3078267C (en) Compositions and methods of modulating the immune response by activating alpha protein kinase 1
AU2019337051B2 (en) Novel cyclic dinucleotide derivative and antibody-drug conjugate thereof
AU2012223012B2 (en) Phosphoramidate derivatives of 5 - fluoro - 2 ' - deoxyuridine for use in the treatment of cancer
EP1778251B1 (en) Nucleoside phosphonate conjugates as anti hiv agents
EP3765474B1 (en) Cyclopentane-based modulators of sting (stimulator of interferon genes)
EP3752516B1 (en) Cyclic dinucleotides as anticancer agents
US20220177510A1 (en) Derivatives of gylcero-manno-heptose adp for use in modulating immune response
CN118055936A (zh) 用于治疗与alpk1活性相关的病症的核苷-双磷酸-庚糖化合物
KR20220012241A (ko) 글리세로-만노-헵토스 포스페이트의 유도체 및 면역 반응 조절시의 이의 용도
JP7641918B2 (ja) 炭素環ヌクレオシド類似体
RU2809547C2 (ru) Новое производное циклического динуклеотида и его конъюгат антитело-лекарственное средство
OA19842A (en) Cyclopentane-based modulators of sting (stimulator of interferon genes).
NZ734908B2 (en) fi-D-2'-DEOXY-2'fi-FLUORO-2'-fi-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT
HK1103649B (en) Nucleoside phosphonate conjugates as anti hiv agents

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20220929

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 6TH ANNIV.) - STANDARD

Year of fee payment: 6

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20241002

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20241002

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 7TH ANNIV.) - STANDARD

Year of fee payment: 7

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250817

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250818