CA3076008A1 - Fluoro substituted porphyrin compounds, pharmaceutical compositions comprising the same, and methods of preparing and using the same - Google Patents
Fluoro substituted porphyrin compounds, pharmaceutical compositions comprising the same, and methods of preparing and using the same Download PDFInfo
- Publication number
- CA3076008A1 CA3076008A1 CA3076008A CA3076008A CA3076008A1 CA 3076008 A1 CA3076008 A1 CA 3076008A1 CA 3076008 A CA3076008 A CA 3076008A CA 3076008 A CA3076008 A CA 3076008A CA 3076008 A1 CA3076008 A1 CA 3076008A1
- Authority
- CA
- Canada
- Prior art keywords
- formula
- subject
- radiation
- ascorbate
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/32—Manganese; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1094—Shielding, protecting against radiation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762565436P | 2017-09-29 | 2017-09-29 | |
| US62/565,436 | 2017-09-29 | ||
| PCT/US2018/052826 WO2019067523A1 (en) | 2017-09-29 | 2018-09-26 | FLUOROSUBSTITUTED PORPHYRIN COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF PREPARATION AND USE THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3076008A1 true CA3076008A1 (en) | 2019-04-04 |
Family
ID=65903171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3076008A Pending CA3076008A1 (en) | 2017-09-29 | 2018-09-26 | Fluoro substituted porphyrin compounds, pharmaceutical compositions comprising the same, and methods of preparing and using the same |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11344574B2 (https=) |
| EP (1) | EP3687551B1 (https=) |
| JP (1) | JP7336805B2 (https=) |
| KR (1) | KR102699638B1 (https=) |
| CN (1) | CN111417400B (https=) |
| CA (1) | CA3076008A1 (https=) |
| MX (1) | MX2020002958A (https=) |
| WO (1) | WO2019067523A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20240116576A (ko) | 2017-04-04 | 2024-07-29 | 바이오미매틱스 제이브이, 엘엘씨 | 방사선 요법 및/또는 화학요법 노출과 연관된 부작용의 치료 및/또는 예방을 위한 방법, 조성물, 및 키트 |
| CN111417400B (zh) | 2017-09-29 | 2022-12-02 | 杜克大学 | 氟取代的卟啉化合物、包含其的药物组合物及其制备和使用方法 |
| CN115192705B (zh) * | 2021-04-13 | 2023-10-13 | 中国科学院化学研究所 | 一种两性离子共价有机聚合物/二氧化钛纳米复合材料及其制备方法和应用 |
| CN116333037A (zh) * | 2021-12-17 | 2023-06-27 | 化学与精细化工广东省实验室 | 含巯基肽与氟代卟啉类偶联用作生物探针 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2520735B2 (ja) * | 1988-07-14 | 1996-07-31 | 東洋薄荷工業株式会社 | ポルフィリン誘導体 |
| IL135949A0 (en) | 1997-11-03 | 2001-05-20 | Univ Duke | Substituted porphyrins |
| JPH11217385A (ja) * | 1998-01-30 | 1999-08-10 | Nihon Schering Kk | 含フッ素ポルフィリン錯体およびそれを含有する造影剤 |
| US6448239B1 (en) * | 1999-06-03 | 2002-09-10 | Trustees Of Princeton University | Peroxynitrite decomposition catalysts and methods of use thereof |
| EP1392328B1 (en) | 2001-01-19 | 2009-08-12 | National Jewish Medical and Research Center | Medicament for protection in radiotherapy |
| EP1718201B1 (en) | 2004-02-09 | 2016-09-14 | Duke University | Substituted porphyrins |
| EA010834B1 (ru) | 2004-03-29 | 2008-12-30 | Инотек Фармасьютикалз Корпорейшн | Пиридилзамещённые порфириновые соединения и способы их применения |
| CN101235036A (zh) | 2007-02-02 | 2008-08-06 | 济南赛文医药技术有限公司 | 一类卟啉衍生物及其作为小分子抗氧化剂的应用 |
| GB0819594D0 (en) * | 2008-10-24 | 2008-12-03 | Univ Coimbrra | Process |
| WO2010080881A1 (en) * | 2009-01-07 | 2010-07-15 | Duke University | Substituted porphyrins |
| WO2015034777A1 (en) | 2013-09-03 | 2015-03-12 | Biomimetix J.V., Llc | Methods of treating biofilms |
| US10064871B2 (en) | 2014-01-22 | 2018-09-04 | Biomimetix Jv, Llc | Methods of treating skin disorders |
| US10080759B2 (en) | 2014-01-22 | 2018-09-25 | Duke University | Methods of treating pruritus |
| CN110291060A (zh) * | 2016-12-20 | 2019-09-27 | 杜克大学 | 制备取代卟啉药物化合物和组合物的方法 |
| WO2018237249A1 (en) | 2017-06-22 | 2018-12-27 | Biomimetix Jv, Llc | Methods, compositions, and kits for treating inflammatory skin conditions |
| CN111417400B (zh) | 2017-09-29 | 2022-12-02 | 杜克大学 | 氟取代的卟啉化合物、包含其的药物组合物及其制备和使用方法 |
-
2018
- 2018-09-26 CN CN201880077161.7A patent/CN111417400B/zh active Active
- 2018-09-26 JP JP2020517334A patent/JP7336805B2/ja active Active
- 2018-09-26 EP EP18861582.7A patent/EP3687551B1/en active Active
- 2018-09-26 CA CA3076008A patent/CA3076008A1/en active Pending
- 2018-09-26 US US16/645,907 patent/US11344574B2/en active Active
- 2018-09-26 MX MX2020002958A patent/MX2020002958A/es unknown
- 2018-09-26 WO PCT/US2018/052826 patent/WO2019067523A1/en not_active Ceased
- 2018-09-26 KR KR1020207010074A patent/KR102699638B1/ko active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2020536055A (ja) | 2020-12-10 |
| JP7336805B2 (ja) | 2023-09-01 |
| KR102699638B1 (ko) | 2024-08-28 |
| WO2019067523A1 (en) | 2019-04-04 |
| EP3687551A1 (en) | 2020-08-05 |
| US20210361702A1 (en) | 2021-11-25 |
| CN111417400A (zh) | 2020-07-14 |
| US11344574B2 (en) | 2022-05-31 |
| EP3687551A4 (en) | 2021-06-23 |
| KR20200079237A (ko) | 2020-07-02 |
| CN111417400B (zh) | 2022-12-02 |
| EP3687551B1 (en) | 2026-04-15 |
| MX2020002958A (es) | 2020-08-20 |
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| Date | Code | Title | Description |
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| U11 | Full renewal or maintenance fee paid |
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