KR102699638B1 - 플루오로 치환 포르피린 화합물, 그를 포함하는 약제학적 조성물, 및 그를 제조하고 사용하는 방법 - Google Patents

플루오로 치환 포르피린 화합물, 그를 포함하는 약제학적 조성물, 및 그를 제조하고 사용하는 방법 Download PDF

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KR102699638B1
KR102699638B1 KR1020207010074A KR20207010074A KR102699638B1 KR 102699638 B1 KR102699638 B1 KR 102699638B1 KR 1020207010074 A KR1020207010074 A KR 1020207010074A KR 20207010074 A KR20207010074 A KR 20207010074A KR 102699638 B1 KR102699638 B1 KR 102699638B1
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radiation
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KR20200079237A (ko
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아이네스 바티닉-하벌리
알탁 토브마얀
이반 스파소제비크
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듀크 유니버시티
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/32—Manganese; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1094—Shielding, protecting against radiation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020207010074A 2017-09-29 2018-09-26 플루오로 치환 포르피린 화합물, 그를 포함하는 약제학적 조성물, 및 그를 제조하고 사용하는 방법 Active KR102699638B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762565436P 2017-09-29 2017-09-29
US62/565,436 2017-09-29
PCT/US2018/052826 WO2019067523A1 (en) 2017-09-29 2018-09-26 FLUOROSUBSTITUTED PORPHYRIN COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF PREPARATION AND USE THEREOF

Publications (2)

Publication Number Publication Date
KR20200079237A KR20200079237A (ko) 2020-07-02
KR102699638B1 true KR102699638B1 (ko) 2024-08-28

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KR1020207010074A Active KR102699638B1 (ko) 2017-09-29 2018-09-26 플루오로 치환 포르피린 화합물, 그를 포함하는 약제학적 조성물, 및 그를 제조하고 사용하는 방법

Country Status (8)

Country Link
US (1) US11344574B2 (https=)
EP (1) EP3687551B1 (https=)
JP (1) JP7336805B2 (https=)
KR (1) KR102699638B1 (https=)
CN (1) CN111417400B (https=)
CA (1) CA3076008A1 (https=)
MX (1) MX2020002958A (https=)
WO (1) WO2019067523A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240116576A (ko) 2017-04-04 2024-07-29 바이오미매틱스 제이브이, 엘엘씨 방사선 요법 및/또는 화학요법 노출과 연관된 부작용의 치료 및/또는 예방을 위한 방법, 조성물, 및 키트
CN111417400B (zh) 2017-09-29 2022-12-02 杜克大学 氟取代的卟啉化合物、包含其的药物组合物及其制备和使用方法
CN115192705B (zh) * 2021-04-13 2023-10-13 中国科学院化学研究所 一种两性离子共价有机聚合物/二氧化钛纳米复合材料及其制备方法和应用
CN116333037A (zh) * 2021-12-17 2023-06-27 化学与精细化工广东省实验室 含巯基肽与氟代卟啉类偶联用作生物探针

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060199792A1 (en) 1999-06-03 2006-09-07 Trustees Of Princeton University Peroxynitrite decomposition catalysts and methods of use thereof
US20080009473A1 (en) 2004-03-29 2008-01-10 Inotek Pharmaceuticals Corporation Pyridyl-substituted porphyrin compounds and methods of use thereof
WO2010080881A1 (en) * 2009-01-07 2010-07-15 Duke University Substituted porphyrins

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2520735B2 (ja) * 1988-07-14 1996-07-31 東洋薄荷工業株式会社 ポルフィリン誘導体
IL135949A0 (en) 1997-11-03 2001-05-20 Univ Duke Substituted porphyrins
JPH11217385A (ja) * 1998-01-30 1999-08-10 Nihon Schering Kk 含フッ素ポルフィリン錯体およびそれを含有する造影剤
EP1392328B1 (en) 2001-01-19 2009-08-12 National Jewish Medical and Research Center Medicament for protection in radiotherapy
EP1718201B1 (en) 2004-02-09 2016-09-14 Duke University Substituted porphyrins
CN101235036A (zh) 2007-02-02 2008-08-06 济南赛文医药技术有限公司 一类卟啉衍生物及其作为小分子抗氧化剂的应用
GB0819594D0 (en) * 2008-10-24 2008-12-03 Univ Coimbrra Process
WO2015034777A1 (en) 2013-09-03 2015-03-12 Biomimetix J.V., Llc Methods of treating biofilms
US10064871B2 (en) 2014-01-22 2018-09-04 Biomimetix Jv, Llc Methods of treating skin disorders
US10080759B2 (en) 2014-01-22 2018-09-25 Duke University Methods of treating pruritus
CN110291060A (zh) * 2016-12-20 2019-09-27 杜克大学 制备取代卟啉药物化合物和组合物的方法
WO2018237249A1 (en) 2017-06-22 2018-12-27 Biomimetix Jv, Llc Methods, compositions, and kits for treating inflammatory skin conditions
CN111417400B (zh) 2017-09-29 2022-12-02 杜克大学 氟取代的卟啉化合物、包含其的药物组合物及其制备和使用方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060199792A1 (en) 1999-06-03 2006-09-07 Trustees Of Princeton University Peroxynitrite decomposition catalysts and methods of use thereof
US20080009473A1 (en) 2004-03-29 2008-01-10 Inotek Pharmaceuticals Corporation Pyridyl-substituted porphyrin compounds and methods of use thereof
WO2010080881A1 (en) * 2009-01-07 2010-07-15 Duke University Substituted porphyrins

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JP2020536055A (ja) 2020-12-10
JP7336805B2 (ja) 2023-09-01
WO2019067523A1 (en) 2019-04-04
EP3687551A1 (en) 2020-08-05
US20210361702A1 (en) 2021-11-25
CN111417400A (zh) 2020-07-14
CA3076008A1 (en) 2019-04-04
US11344574B2 (en) 2022-05-31
EP3687551A4 (en) 2021-06-23
KR20200079237A (ko) 2020-07-02
CN111417400B (zh) 2022-12-02
EP3687551B1 (en) 2026-04-15
MX2020002958A (es) 2020-08-20

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