CA3066689C - Treatment of inflammatory diseases with inhibitors of c5a activity - Google Patents
Treatment of inflammatory diseases with inhibitors of c5a activity Download PDFInfo
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- CA3066689C CA3066689C CA3066689A CA3066689A CA3066689C CA 3066689 C CA3066689 C CA 3066689C CA 3066689 A CA3066689 A CA 3066689A CA 3066689 A CA3066689 A CA 3066689A CA 3066689 C CA3066689 C CA 3066689C
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
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| PCT/EP2018/065676 WO2018234118A1 (en) | 2017-06-23 | 2018-06-13 | Treatment of inflammatory diseases with inhibitors of c5a activity |
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| IL275264B1 (en) | 2017-12-13 | 2025-10-01 | Regeneron Pharma | Anti-C5 antibody combinations and their uses |
| CA3132771A1 (en) * | 2019-03-14 | 2020-09-17 | Morphosys Ag | Antibodies targeting c5ar |
| TWI869528B (zh) * | 2020-01-13 | 2025-01-11 | 美商威特拉公司 | C5ar1抗體分子及其用途 |
| IL296036A (en) * | 2020-03-27 | 2022-10-01 | Inflarx Gmbh | Inhibitors of c5a for the treatment of corona virus infection |
| WO2021259160A1 (en) * | 2020-06-24 | 2021-12-30 | Staidson (Beijing) Biopharmaceuticals Co., Ltd. | Antibodies specifically recognizing c5a and uses thereof |
| JP2024502863A (ja) | 2021-01-13 | 2024-01-23 | ビステラ， インコーポレイテッド | ヒト化補体５ａ受容体１抗体及びその使用方法 |
| US12180274B2 (en) | 2023-05-26 | 2024-12-31 | Inflarx Gmbh | Treatment of pneumonia and ARDS with inhibitors of C5a and IL-6 activity |
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| US4704355A (en) | 1985-03-27 | 1987-11-03 | New Horizons Diagnostics Corporation | Assay utilizing ATP encapsulated within liposome particles |
| CA2025907A1 (en) | 1989-09-21 | 1991-03-22 | Franklin D. Collins | Method of transporting compositions across the blood brain barrier |
| DE69133566T2 (de) | 1990-01-12 | 2007-12-06 | Amgen Fremont Inc. | Bildung von xenogenen Antikörpern |
| AUPO755097A0 (en) | 1997-06-25 | 1997-07-17 | University Of Queensland, The | Receptor agonist and antagonist |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
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| TWI465434B (zh) * | 2008-12-22 | 2014-12-21 | Chemocentryx Inc | Ｃ５ａＲ拮抗劑 |
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| HUE033644T2 (en) | 2010-06-24 | 2017-12-28 | Chemocentryx Inc | C5AR antagonists |
| SMT201700552T1 (it) * | 2013-03-14 | 2018-01-11 | Alnylam Pharmaceuticals Inc | COMPOSIZIONI DI iRNA DEL COMPONENTE DEL COMPLEMENTO C5 E LORO METODI DI USO |
| US20160060351A1 (en) * | 2013-05-08 | 2016-03-03 | Novo Nordisk A/S | Use of C5AR Antagonists |
| EP3119802B1 (en) * | 2014-03-20 | 2019-12-04 | InflaRx GmbH | Inhibitors of c5a for the treatment of viral pneumonia |
| EP3194596A1 (en) | 2014-09-16 | 2017-07-26 | Alnylam Pharmaceuticals, Inc. | Complement component c5 irna compositions and methods of use thereof |
| US10544209B2 (en) | 2014-10-15 | 2020-01-28 | Alexion Pharmaceuticals, Inc. | Methods of replicating a large scale eculizumab production cell culture |
| FR3030515B1 (fr) * | 2014-12-23 | 2017-01-20 | Galderma Res & Dev | Nouveaux composes antagonistes des recepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies mediees par des chimiokines |
| US20180142010A1 (en) | 2015-06-26 | 2018-05-24 | Alexion Pharmaceuticals, Inc. | Method for treating a patient in compliance with vaccination with eculizumab or an eculizumab variant |
| JP7121722B2 (ja) | 2016-04-04 | 2022-08-18 | ケモセントリックス，インコーポレイティド | 可溶性Ｃ５ａＲアンタゴニスト |
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| EP3642230A1 (en) | 2020-04-29 |
| CA3066689A1 (en) | 2018-12-27 |
| SG11201912882QA (en) | 2020-01-30 |
| CN111201241A (zh) | 2020-05-26 |
| TW201904611A (zh) | 2019-02-01 |
| TWI786132B (zh) | 2022-12-11 |
| IL271074A (en) | 2020-01-30 |
| KR20200020727A (ko) | 2020-02-26 |
| JP7502865B2 (ja) | 2024-06-19 |
| AU2018286754A1 (en) | 2019-12-19 |
| WO2018234118A1 (en) | 2018-12-27 |
| JP2020524696A (ja) | 2020-08-20 |
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