JP7502865B2 - Ｃ５ａ活性のインヒビターでの炎症性疾患の処置 - Google Patents

Ｃ５ａ活性のインヒビターでの炎症性疾患の処置 Download PDF

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Publication number
JP7502865B2
JP7502865B2 JP2019570986A JP2019570986A JP7502865B2 JP 7502865 B2 JP7502865 B2 JP 7502865B2 JP 2019570986 A JP2019570986 A JP 2019570986A JP 2019570986 A JP2019570986 A JP 2019570986A JP 7502865 B2 JP7502865 B2 JP 7502865B2
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antibody
amino acid
human
binding
ifx
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JP2020524696A5 (cg-RX-API-DMAC7.html
JP2020524696A (ja
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レンフォン・グオ
ニールス・ツェー・リーデマン
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InflaRx GmbH
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InflaRx GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
JP2019570986A 2017-06-23 2018-06-13 Ｃ５ａ活性のインヒビターでの炎症性疾患の処置 Active JP7502865B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP17177657 2017-06-23
EP17177657.8 2017-06-23
EP17189938 2017-09-07
EP17189938.8 2017-09-07
PCT/EP2018/065676 WO2018234118A1 (en) 2017-06-23 2018-06-13 Treatment of inflammatory diseases with inhibitors of c5a activity

Publications (3)

Publication Number Publication Date
JP2020524696A JP2020524696A (ja) 2020-08-20
JP2020524696A5 JP2020524696A5 (cg-RX-API-DMAC7.html) 2021-07-26
JP7502865B2 true JP7502865B2 (ja) 2024-06-19

Family

ID=62636193

Family Applications (1)

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JP2019570986A Active JP7502865B2 (ja) 2017-06-23 2018-06-13 Ｃ５ａ活性のインヒビターでの炎症性疾患の処置

Country Status (10)

Country Link
EP (1) EP3642230A1 (cg-RX-API-DMAC7.html)
JP (1) JP7502865B2 (cg-RX-API-DMAC7.html)
KR (1) KR20200020727A (cg-RX-API-DMAC7.html)
CN (1) CN111201241A (cg-RX-API-DMAC7.html)
AU (1) AU2018286754A1 (cg-RX-API-DMAC7.html)
CA (1) CA3066689C (cg-RX-API-DMAC7.html)
IL (1) IL271074A (cg-RX-API-DMAC7.html)
SG (1) SG11201912882QA (cg-RX-API-DMAC7.html)
TW (1) TWI786132B (cg-RX-API-DMAC7.html)
WO (1) WO2018234118A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY191668A (en) 2016-06-14 2022-07-06 Regeneron Pharma Anti-c5 antibodies and uses thereof
IL275264B1 (en) 2017-12-13 2025-10-01 Regeneron Pharma Anti-C5 antibody combinations and their uses
CA3132771A1 (en) * 2019-03-14 2020-09-17 Morphosys Ag Antibodies targeting c5ar
TWI869528B (zh) * 2020-01-13 2025-01-11 美商威特拉公司 C5ar1抗體分子及其用途
IL296036A (en) * 2020-03-27 2022-10-01 Inflarx Gmbh Inhibitors of c5a for the treatment of corona virus infection
WO2021259160A1 (en) * 2020-06-24 2021-12-30 Staidson (Beijing) Biopharmaceuticals Co., Ltd. Antibodies specifically recognizing c5a and uses thereof
JP2024502863A (ja) 2021-01-13 2024-01-23 ビステラ， インコーポレイテッド ヒト化補体５ａ受容体１抗体及びその使用方法
US12180274B2 (en) 2023-05-26 2024-12-31 Inflarx Gmbh Treatment of pneumonia and ARDS with inhibitors of C5a and IL-6 activity

Citations (9)

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WO2003033528A1 (en) 2001-10-17 2003-04-24 University Of Queensland Cyclic peptides as g-protein-coupled receptor antagonists
WO2008009062A1 (en) 2006-07-21 2008-01-24 Promics Pty Ltd Treatment for intimal hyperplasia and related conditions
WO2010075257A1 (en) 2008-12-22 2010-07-01 Chemocentryx, Inc. C5ar antagonists
WO2011163640A1 (en) 2010-06-24 2011-12-29 Chemocentryx, Inc. C5ar antagonists
JP2012514465A (ja) 2009-01-08 2012-06-28 アリゲーター・バイオサイエンス・アーベー 新規なポリペプチドおよびその使用
WO2015140304A1 (en) 2014-03-20 2015-09-24 Inflarx Gmbh Inhibitors of c5a for the treatment of viral pneumonia
JP2016518331A (ja) 2013-03-14 2016-06-23 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 補体成分Ｃ５ｉＲＮＡ組成物及びその使用方法
JP2016523829A (ja) 2013-05-08 2016-08-12 ノヴォ ノルディスク アー／エス Ｃ５ａｒアンタゴニストの使用
JP2020515643A (ja) 2017-04-03 2020-05-28 インフラルクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＩｎｆｌａＲｘ ＧｍｂＨ Ｃ５ａ活性のインヒビターでの炎症性疾患の処置

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US4704355A (en) 1985-03-27 1987-11-03 New Horizons Diagnostics Corporation Assay utilizing ATP encapsulated within liposome particles
CA2025907A1 (en) 1989-09-21 1991-03-22 Franklin D. Collins Method of transporting compositions across the blood brain barrier
DE69133566T2 (de) 1990-01-12 2007-12-06 Amgen Fremont Inc. Bildung von xenogenen Antikörpern
AUPO755097A0 (en) 1997-06-25 1997-07-17 University Of Queensland, The Receptor agonist and antagonist
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
DK2860251T3 (en) 2004-02-12 2018-06-06 Archemix Llc APTAPMER PHARMACEUTICALS USEFUL IN TREATMENT OF COMPLEMENT-RELATED DISEASES
MXPA06011051A (es) * 2004-03-26 2007-04-13 Promics Pty Ltd Tratamiento de condiciones neurologicas usando complemento de moduladores del receptor c5a.
GB0617734D0 (en) 2006-09-08 2006-10-18 Evolutec Ltd Method of treating peripheral nerve disorders
EP2327725A1 (en) 2009-11-26 2011-06-01 InflaRx GmbH Anti-C5a binding moieties with high blocking activity
EP3194596A1 (en) 2014-09-16 2017-07-26 Alnylam Pharmaceuticals, Inc. Complement component c5 irna compositions and methods of use thereof
US10544209B2 (en) 2014-10-15 2020-01-28 Alexion Pharmaceuticals, Inc. Methods of replicating a large scale eculizumab production cell culture
FR3030515B1 (fr) * 2014-12-23 2017-01-20 Galderma Res & Dev Nouveaux composes antagonistes des recepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies mediees par des chimiokines
US20180142010A1 (en) 2015-06-26 2018-05-24 Alexion Pharmaceuticals, Inc. Method for treating a patient in compliance with vaccination with eculizumab or an eculizumab variant
JP7121722B2 (ja) 2016-04-04 2022-08-18 ケモセントリックス，インコーポレイティド 可溶性Ｃ５ａＲアンタゴニスト

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003033528A1 (en) 2001-10-17 2003-04-24 University Of Queensland Cyclic peptides as g-protein-coupled receptor antagonists
WO2008009062A1 (en) 2006-07-21 2008-01-24 Promics Pty Ltd Treatment for intimal hyperplasia and related conditions
WO2010075257A1 (en) 2008-12-22 2010-07-01 Chemocentryx, Inc. C5ar antagonists
JP2012514465A (ja) 2009-01-08 2012-06-28 アリゲーター・バイオサイエンス・アーベー 新規なポリペプチドおよびその使用
WO2011163640A1 (en) 2010-06-24 2011-12-29 Chemocentryx, Inc. C5ar antagonists
JP2016518331A (ja) 2013-03-14 2016-06-23 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 補体成分Ｃ５ｉＲＮＡ組成物及びその使用方法
JP2016523829A (ja) 2013-05-08 2016-08-12 ノヴォ ノルディスク アー／エス Ｃ５ａｒアンタゴニストの使用
WO2015140304A1 (en) 2014-03-20 2015-09-24 Inflarx Gmbh Inhibitors of c5a for the treatment of viral pneumonia
JP2020515643A (ja) 2017-04-03 2020-05-28 インフラルクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＩｎｆｌａＲｘ ＧｍｂＨ Ｃ５ａ活性のインヒビターでの炎症性疾患の処置

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NATURE REVIEWS, 2015, Vol.14, pp.857-877
Study NCT03001622 on Date: March 20, 2017 (v3)，ClinicalTrials.gov archive[online]，2017年3月20日，<URL: https://clinicaltrials.gov/ct2/history/NCT03001622>

Also Published As

Publication number Publication date
EP3642230A1 (en) 2020-04-29
CA3066689A1 (en) 2018-12-27
SG11201912882QA (en) 2020-01-30
CA3066689C (en) 2024-01-16
CN111201241A (zh) 2020-05-26
TW201904611A (zh) 2019-02-01
TWI786132B (zh) 2022-12-11
IL271074A (en) 2020-01-30
KR20200020727A (ko) 2020-02-26
AU2018286754A1 (en) 2019-12-19
WO2018234118A1 (en) 2018-12-27
JP2020524696A (ja) 2020-08-20

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