CA3059591A1 - Methods for multiplex detection of alleles associated with corneal dystrophy - Google Patents

Methods for multiplex detection of alleles associated with corneal dystrophy Download PDF

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Publication number
CA3059591A1
CA3059591A1 CA3059591A CA3059591A CA3059591A1 CA 3059591 A1 CA3059591 A1 CA 3059591A1 CA 3059591 A CA3059591 A CA 3059591A CA 3059591 A CA3059591 A CA 3059591A CA 3059591 A1 CA3059591 A1 CA 3059591A1
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CA
Canada
Prior art keywords
tgfbi
labeled
probe
reaction mixture
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3059591A
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English (en)
French (fr)
Inventor
Connie CHAO-SHERN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avellino Lab USA Inc
Original Assignee
Avellino Lab USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avellino Lab USA Inc filed Critical Avellino Lab USA Inc
Publication of CA3059591A1 publication Critical patent/CA3059591A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA3059591A 2017-04-10 2018-04-10 Methods for multiplex detection of alleles associated with corneal dystrophy Pending CA3059591A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762483588P 2017-04-10 2017-04-10
US62/483,588 2017-04-10
US201762573537P 2017-10-17 2017-10-17
US62/573,537 2017-10-17
US201862624661P 2018-01-31 2018-01-31
US201862624660P 2018-01-31 2018-01-31
US62/624,660 2018-01-31
US62/624,661 2018-01-31
PCT/US2018/026962 WO2018191304A1 (en) 2017-04-10 2018-04-10 Methods for multiplex detection of alleles associated with corneal dystrophy

Publications (1)

Publication Number Publication Date
CA3059591A1 true CA3059591A1 (en) 2018-10-18

Family

ID=63792919

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3059591A Pending CA3059591A1 (en) 2017-04-10 2018-04-10 Methods for multiplex detection of alleles associated with corneal dystrophy

Country Status (8)

Country Link
US (1) US11905560B2 (enExample)
EP (1) EP3610015A4 (enExample)
JP (2) JP7303113B2 (enExample)
KR (1) KR102701188B1 (enExample)
CN (1) CN110945126B (enExample)
AU (1) AU2018250570A1 (enExample)
CA (1) CA3059591A1 (enExample)
WO (1) WO2018191304A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116024335A (zh) * 2023-02-14 2023-04-28 福建佰孟医学科技有限公司 一种角膜营养不良基因突变检测引物组合物、试剂盒及检测方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102241836B1 (ko) * 2019-06-14 2021-04-21 솔젠트 (주) 듀얼 체크 올리고를 이용한 유전자 다형성 검사 방법
CN113088569A (zh) * 2020-01-09 2021-07-09 北京中因科技有限公司 一种多重荧光定量pcr试剂盒
CN113999899A (zh) * 2020-07-28 2022-02-01 首都医科大学附属北京同仁医院 一种检测tgfbi基因突变的试剂盒
CN113848327A (zh) * 2021-09-18 2021-12-28 天津市眼科医院 用于高度近视风险预测以及高度近视辅助诊断的标志物组合物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962332A (en) * 1994-03-17 1999-10-05 University Of Massachusetts Detection of trinucleotide repeats by in situ hybridization
KR20070076532A (ko) * 2006-01-18 2007-07-24 메디제네스(주) 각막이영양증 진단용 ｄｎａ 칩
KR101041606B1 (ko) 2009-08-18 2011-06-15 (주)아벨리노 다중 스팟 금속 증착형 나노구조배열 각막이상증 진단용 핵산칩 및 이의 제조방법
CN102741402A (zh) 2009-10-30 2012-10-17 爱科来株式会社 Mpl基因多态性检测用探针及其用途
KR101320943B1 (ko) 2010-04-20 2013-10-23 연세대학교 산학협력단 Ｔｇｆｂｉ 유전자 변이 각막 이상증의 예방 또는 치료용 약제학적 조성물 및 그의 스크리닝 방법
KR101258166B1 (ko) 2010-09-01 2013-04-25 연세대학교 산학협력단 Ｔｇｆｂｉ 유전자 변이 각막 이상증의 예방 또는 치료용 약제학적 조성물 및 그의 스크리닝 방법
KR101125212B1 (ko) 2010-10-01 2012-03-21 (주)아벨리노 아벨리노 각막이상증 진단용 시스템
CN105899681B (zh) 2013-11-15 2021-06-22 阿维利诺美国实验室股份有限公司 用于与眼科状况有关的等位基因的多重检测的方法
KR20160088028A (ko) * 2015-01-15 2016-07-25 정정원 Tgfbi-연관 각막이상증 진단방법 및 키트

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116024335A (zh) * 2023-02-14 2023-04-28 福建佰孟医学科技有限公司 一种角膜营养不良基因突变检测引物组合物、试剂盒及检测方法

Also Published As

Publication number Publication date
JP7303113B2 (ja) 2023-07-04
EP3610015A4 (en) 2021-05-19
JP2023116533A (ja) 2023-08-22
WO2018191304A1 (en) 2018-10-18
US11905560B2 (en) 2024-02-20
CN110945126B (zh) 2024-04-26
US20200040397A1 (en) 2020-02-06
JP2020516280A (ja) 2020-06-11
KR20200017386A (ko) 2020-02-18
CN110945126A (zh) 2020-03-31
AU2018250570A1 (en) 2019-11-21
EP3610015A1 (en) 2020-02-19
KR102701188B1 (ko) 2024-08-30

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