CA3052489A1 - Ecm hydrogel for treating esophageal inflammation - Google Patents

Ecm hydrogel for treating esophageal inflammation Download PDF

Info

Publication number
CA3052489A1
CA3052489A1 CA3052489A CA3052489A CA3052489A1 CA 3052489 A1 CA3052489 A1 CA 3052489A1 CA 3052489 A CA3052489 A CA 3052489A CA 3052489 A CA3052489 A CA 3052489A CA 3052489 A1 CA3052489 A1 CA 3052489A1
Authority
CA
Canada
Prior art keywords
ecm
hydrogel
esophageal
esophagus
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3052489A
Other languages
English (en)
French (fr)
Inventor
Stephen Francis Badylak
Juan Diego Naranjo Gutierrez
Lindsey Tamiko Saldin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pittsburgh filed Critical University of Pittsburgh
Publication of CA3052489A1 publication Critical patent/CA3052489A1/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3052489A 2017-03-02 2018-03-02 Ecm hydrogel for treating esophageal inflammation Pending CA3052489A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762465985P 2017-03-02 2017-03-02
US62/465,985 2017-03-02
PCT/US2018/020758 WO2018161028A1 (en) 2017-03-02 2018-03-02 Ecm hydrogel for treating esophageal inflammation

Publications (1)

Publication Number Publication Date
CA3052489A1 true CA3052489A1 (en) 2018-09-07

Family

ID=63371156

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3052489A Pending CA3052489A1 (en) 2017-03-02 2018-03-02 Ecm hydrogel for treating esophageal inflammation

Country Status (9)

Country Link
US (3) US11213545B2 (enExample)
EP (2) EP3589292B1 (enExample)
JP (3) JP7203428B2 (enExample)
KR (1) KR102745611B1 (enExample)
CN (1) CN110352061A (enExample)
AU (2) AU2018226867B2 (enExample)
CA (1) CA3052489A1 (enExample)
ES (2) ES2957291T3 (enExample)
WO (1) WO2018161028A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111265719B (zh) 2014-03-21 2023-01-10 匹兹堡大学-联邦高等教育体系 最终消毒的来自细胞外基质的水凝胶的制备方法
ES3014543T3 (en) 2016-03-02 2025-04-23 Univ Pittsburgh Commonwealth Sys Higher Education Matrix bound nanovesicles and their use
JP7203428B2 (ja) 2017-03-02 2023-01-13 ユニバーシティ オブ ピッツバーグ - オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 食道の炎症を処置するためのecmヒドロゲル
CN110352064B (zh) 2017-03-02 2023-11-10 联邦高等教育系统匹兹堡大学 用于癌症治疗的胞外基质(ecm)水凝胶及其可溶级分
WO2018204848A1 (en) 2017-05-05 2018-11-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Ocular applications of matrix bound vesicles (mbvs)
EP3787642A4 (en) 2018-05-03 2022-09-21 University of Pittsburgh - of the Commonwealth System of Higher Education IL-33 CONTAINING MATRIX-BONDED VESICLES (MBVS) AND THEIR USE
AU2019288591B2 (en) * 2018-06-21 2024-06-13 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Use of a urinary bladder ECM hydrogel as an esophageal submucosal fluid cushion
KR20210024062A (ko) * 2018-06-21 2021-03-04 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 식도의 점막하 유체 쿠션으로 세포외 기질(ecm) 사용
WO2019246444A1 (en) * 2018-06-21 2019-12-26 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Extracellular matrix (ecm) hydrogel as a submucosal fluid cushion
JP2022524380A (ja) * 2019-03-13 2022-05-02 ユニバーシティ オブ ピッツバーグ - オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 音響細胞外マトリックスヒドロゲルおよびそれらの使用
CA3171384A1 (en) 2020-02-28 2021-09-02 Texas Medical Center Sprayable stimuli-responsive micro-hydrogels for adhesion prevention and enhanced tissue healing
EP4230725A4 (en) * 2020-11-17 2025-02-12 Cellartgen Inc. ESOPHAGEAL EXTRACELLULAR MATRIX DERIVED SCAFFOLD FOR ESOPHAGEAL ORGANOID CULTURE AND TRANSPLANTATION, AND PRODUCTION METHOD THEREOF

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155095A (en) 1961-02-07 1964-11-03 Adolph M Brown Anastomosis method and means
US4294241A (en) 1977-06-09 1981-10-13 Teruo Miyata Collagen skin dressing
US4582640A (en) 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
US4563350A (en) 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
US4978668A (en) 1986-09-02 1990-12-18 Purdue Research Foundation Treatment to reduce ischemic tissue injury
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US4956178A (en) 1988-07-11 1990-09-11 Purdue Research Foundation Tissue graft composition
US5007927A (en) 1989-10-24 1991-04-16 Purdue Research Foundation Muscle-powered cardiac assist device
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5354274A (en) 1992-08-20 1994-10-11 Methodist Hospital Of Indiana, Inc. Device for oral administration of liquids
US6653291B1 (en) 1992-11-13 2003-11-25 Purdue Research Foundation Composition and method for production of transformed cells
US5641518A (en) 1992-11-13 1997-06-24 Purdue Research Foundation Method of repairing bone tissue
US5352463A (en) 1992-11-13 1994-10-04 Badylak Steven F Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor
US5275826A (en) 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US6475232B1 (en) 1996-12-10 2002-11-05 Purdue Research Foundation Stent with reduced thrombogenicity
DE69527141T2 (de) 1994-04-29 2002-11-07 Scimed Life Systems, Inc. Stent mit kollagen
US6485723B1 (en) 1995-02-10 2002-11-26 Purdue Research Foundation Enhanced submucosal tissue graft constructs
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
DE69622548T2 (de) 1995-04-07 2003-09-18 Methodist Health Group, Inc. Gewebetransplantat zur blasenrekonstruktion
US5711969A (en) 1995-04-07 1998-01-27 Purdue Research Foundation Large area submucosal tissue graft constructs
CA2160647C (en) 1995-10-16 2002-05-28 Thomas William Garay Helical bearing anchor catcher
US5755791A (en) 1996-04-05 1998-05-26 Purdue Research Foundation Perforated submucosal tissue graft constructs
CA2263421C (en) 1996-08-23 2012-04-17 William A. Cook Graft prosthesis, materials and methods
ES2213835T3 (es) 1996-09-16 2004-09-01 Purdue Research Foundation Injerto de tejidos intestinales submucosales para la reparacion de tejidos neurologicos.
JP4676580B2 (ja) 1996-11-05 2011-04-27 パーデュー・リサーチ・ファウンデーション 心筋移植片構成物
TW510803B (en) 1996-11-20 2002-11-21 Yasuhiko Shimizu Man-made esophagus and its manufacturing method
AU728949C (en) 1996-12-10 2007-03-29 Purdue Research Foundation Submucosa extracts
DE69720252T2 (de) 1996-12-10 2003-12-04 Purdue Research Foundation, West Lafayette Gewebetransplantat aus der magensubmukosa
DK1671604T3 (da) 1996-12-10 2009-11-09 Purdue Research Foundation Ventil af syntetisk væv
US6696270B2 (en) 1996-12-10 2004-02-24 Purdue Research Foundation Gastric submucosal tissue as a novel diagnostic tool
JP4084420B2 (ja) 1996-12-10 2008-04-30 パーデュー・リサーチ・ファウンデーション 管状粘膜下組織移植片構成物
ES2263185T3 (es) 1996-12-10 2006-12-01 Purdue Research Foundation Biomaterial derivado de tejido hepatico de vertebrados.
AU740913B2 (en) 1997-09-11 2001-11-15 Purdue Research Foundation Galactosidase modified submucosal tissue
WO1999043786A2 (en) 1998-02-27 1999-09-02 Purdue Research Foundation Submucosa gel compositions
US6448076B2 (en) 1998-09-15 2002-09-10 The Regents Of The University Of Michigan Method for chemically acellularizing a biological tissue sample
AU759272B2 (en) 1998-12-01 2003-04-10 Medical College Of Ohio At Toledo Submucosa modulation of mammalian immune response
US6918396B1 (en) 1998-12-01 2005-07-19 Purdue Research Foundation Method for vocal cord reconstruction
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US6579538B1 (en) 1999-12-22 2003-06-17 Acell, Inc. Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof
WO2002014480A2 (en) 2000-08-16 2002-02-21 Duke University Decellularized tissue engineered constructs and tissues
BRPI0115531B1 (pt) * 2000-11-22 2015-10-13 Rxkinetix Inc composição terapêutica útil para o tratamento de mucosite em um local de mucosa como efeito colateral de terapia de câncer
AU2003202261A1 (en) 2002-01-11 2003-07-30 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue
AU2003210474A1 (en) 2002-01-11 2003-07-30 Purdue Research Foundation Composition and method for inhibiting hypersensitivity
NZ536611A (en) 2002-05-02 2006-04-28 Purdue Research Foundation Vascularization enhanced intestinal submucosa tissue graft constructs prepared by seeding intestinal submucosa tissue in vitro with endothelial cells or endothelial cell precursors
CN1665527A (zh) 2002-05-02 2005-09-07 普渡研究基金会 血管化增强的移植构造物
WO2003092381A1 (en) 2002-05-02 2003-11-13 Purdue Research Foundation Vascularization enhanced graft constructs
US7402319B2 (en) 2002-09-27 2008-07-22 Board Of Regents, The University Of Texas System Cell-free tissue replacement for tissue engineering
US20040191226A1 (en) 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of body wall
US20040187877A1 (en) 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of liver tissue
US20040175366A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
US20040176855A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
CA2530490A1 (en) 2003-06-25 2005-01-13 Stephen F. Badylak Conditioned matrix compositions for tissue restoration
US7326571B2 (en) 2003-07-17 2008-02-05 Boston Scientific Scimed, Inc. Decellularized bone marrow extracellular matrix
US8741352B2 (en) 2003-08-25 2014-06-03 Cook Biotech Incorporated Graft materials containing ECM components, and methods for their manufacture
US8021692B2 (en) 2003-08-25 2011-09-20 Cook Biotech Incorporated Graft materials containing bioactive substances, and methods for their manufacture
ES2354527T3 (es) 2004-03-19 2011-03-15 Tamura Plastic Mfg. Co, Ltd. Visor para automóvil.
US7905826B2 (en) 2004-11-03 2011-03-15 Cook Incorporated Methods for modifying vascular vessel walls
US8874204B2 (en) 2004-12-20 2014-10-28 Cardiac Pacemakers, Inc. Implantable medical devices comprising isolated extracellular matrix
US9138445B2 (en) 2005-03-09 2015-09-22 Cook Biotech Incorporated Medical graft materials with adherent extracellular matrix fibrous mass
AU2006265682A1 (en) 2005-07-01 2007-01-11 University Of Pittsburgh Wound healing polymeric networks
US20070166396A1 (en) 2006-01-06 2007-07-19 University Of Pittsburgh Extracellular matrix based gastroesophageal junction reinforcement device
US8241908B2 (en) 2006-05-16 2012-08-14 Becton, Dickinson And Company Extracellular matrix coated surface for culturing cells
WO2008008266A2 (en) 2006-07-07 2008-01-17 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Biohybrid elastomeric scaffolds and methods of use thereof
CN106390200A (zh) 2006-10-23 2017-02-15 库克生物科技公司 组分特性增强的处理的ecm材料
US8361503B2 (en) 2007-03-02 2013-01-29 University of Pittsburgh—of the Commonwealth System of Higher Education Extracellular matrix-derived gels and related methods
US20110184439A1 (en) 2008-05-09 2011-07-28 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Biological Matrix for Cardiac Repair
WO2010099463A2 (en) 2009-02-27 2010-09-02 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Joint bioscaffolds
US8716438B2 (en) 2009-10-09 2014-05-06 University of Pittsburgh—of the Commonwealth System of Higher Education Matricryptic ECM peptides for tissue reconstruction
WO2011087743A2 (en) 2009-12-22 2011-07-21 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Decellularized adipose cell growth scaffold
WO2012024390A2 (en) 2010-08-17 2012-02-23 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biohybrid composite scaffold
HUE031405T2 (en) 2011-04-12 2017-07-28 Novo Nordisk As Double-acylated GLP-1 derivatives
US20140356331A1 (en) 2011-07-08 2014-12-04 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Injectable cns-derived ecm for tissue reconstruction
DK2953659T3 (da) 2013-02-08 2019-11-25 Acell Inc Fremgangsmåder til at fremstille bioaktive geler fra extracellulært matrixmateriale
JP6461096B2 (ja) 2013-04-08 2019-01-30 リージェンティーズ コーポレイション 結腸切除なしに炎症性腸疾患を処置するための方法および組成物
US9861662B2 (en) 2013-07-03 2018-01-09 University of Pittsburgh—of the Commonwealth System of Higher Education Bone-derived extra cellular matrix gel
ITMI20131924A1 (it) 2013-11-20 2015-05-21 Cosmo Technologies Ltd Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica
US10286119B2 (en) 2014-01-24 2019-05-14 University of Pittsburgh—of the Commonwealth System of Higher Education Extracellular matrix mesh coating
CN111265719B (zh) 2014-03-21 2023-01-10 匹兹堡大学-联邦高等教育体系 最终消毒的来自细胞外基质的水凝胶的制备方法
US20170049932A1 (en) 2014-04-24 2017-02-23 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Fractionating Extracellular Matrix to Modulate Bioactivity and the Host Response
EP3319653A4 (en) 2015-07-10 2019-03-27 University of Pittsburgh - Of the Commonwealth System of Higher Education METHOD FOR PRODUCING ECM EQUIPMENT AND HYDROGELS FROM COLON
EP3347063B1 (en) 2015-09-10 2025-11-19 University of Pittsburgh - of the Commonwealth System of Higher Education Bi-layer extra cellular matrix scaffolds and uses therefor
ES2873519T3 (es) 2015-09-18 2021-11-03 Univ Pittsburgh Commonwealth Sys Higher Education Matriz extracelular soluble no gelificante con actividad biológica
CN108699522B (zh) 2016-01-13 2022-05-27 高等教育联邦系统-匹兹堡大学 血管细胞外基质水凝胶
ES3014543T3 (en) 2016-03-02 2025-04-23 Univ Pittsburgh Commonwealth Sys Higher Education Matrix bound nanovesicles and their use
US11389566B2 (en) 2016-03-14 2022-07-19 Regentys Corporation Method and composition for treating inflammatory bowel disease
CN110352064B (zh) * 2017-03-02 2023-11-10 联邦高等教育系统匹兹堡大学 用于癌症治疗的胞外基质(ecm)水凝胶及其可溶级分
JP7203428B2 (ja) 2017-03-02 2023-01-13 ユニバーシティ オブ ピッツバーグ - オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 食道の炎症を処置するためのecmヒドロゲル
US11389569B2 (en) 2017-04-03 2022-07-19 University of Pittsburgh—of the Commonwealth System of Higher Education Biodegradable, porous, thermally responsive injectable hydrogel as soft tissue defect filler
WO2018204848A1 (en) 2017-05-05 2018-11-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Ocular applications of matrix bound vesicles (mbvs)
CN111263647A (zh) 2017-10-24 2020-06-09 达沃有限公司 含羟基丁酸根的软组织修复植入物
EP3787642A4 (en) 2018-05-03 2022-09-21 University of Pittsburgh - of the Commonwealth System of Higher Education IL-33 CONTAINING MATRIX-BONDED VESICLES (MBVS) AND THEIR USE

Also Published As

Publication number Publication date
EP4252842A2 (en) 2023-10-04
ES2957291T3 (es) 2024-01-16
US20200009187A1 (en) 2020-01-09
WO2018161028A1 (en) 2018-09-07
AU2018226867A1 (en) 2019-08-22
EP3589292A1 (en) 2020-01-08
EP3589292B1 (en) 2023-08-23
JP2020509048A (ja) 2020-03-26
EP3589292A4 (en) 2020-12-09
US11213545B2 (en) 2022-01-04
ES3039679T3 (en) 2025-10-23
JP7681909B2 (ja) 2025-05-23
CN110352061A (zh) 2019-10-18
KR102745611B1 (ko) 2024-12-20
US20240189349A1 (en) 2024-06-13
JP2025019254A (ja) 2025-02-06
KR20190120258A (ko) 2019-10-23
AU2024200617B2 (en) 2025-10-23
AU2024200617A1 (en) 2024-02-22
US20220249549A1 (en) 2022-08-11
EP4252842A3 (en) 2023-10-25
AU2018226867B2 (en) 2023-11-02
US11707485B2 (en) 2023-07-25
US12303533B2 (en) 2025-05-20
JP7203428B2 (ja) 2023-01-13
EP4252842B1 (en) 2025-06-25
JP2023024578A (ja) 2023-02-16

Similar Documents

Publication Publication Date Title
AU2024200617B2 (en) Ecm hydrogel for treating esophageal inflammation
JP2024060076A (ja) 食道粘膜下流体クッションとしての膀胱ecmヒドロゲルの使用
JP2024060075A (ja) 食道粘膜下流体クッションとしての細胞外マトリックス(ecm)ヒドロゲルの使用
HK40091837B (en) Ecm hydrogel for treating esophageal inflammation
HK40091837A (en) Ecm hydrogel for treating esophageal inflammation
HK40012466B (en) Ecm hydrogel for treating esophageal inflammation
HK40012466A (en) Ecm hydrogel for treating esophageal inflammation

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20230302

EEER Examination request

Effective date: 20230302

EEER Examination request

Effective date: 20230302