CA3047313A1 - Enhanced hat family transposon-mediated gene transfer and associated compositions, systems, and methods - Google Patents

Enhanced hat family transposon-mediated gene transfer and associated compositions, systems, and methods Download PDF

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Publication number
CA3047313A1
CA3047313A1 CA3047313A CA3047313A CA3047313A1 CA 3047313 A1 CA3047313 A1 CA 3047313A1 CA 3047313 A CA3047313 A CA 3047313A CA 3047313 A CA3047313 A CA 3047313A CA 3047313 A1 CA3047313 A1 CA 3047313A1
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Prior art keywords
transposase
cell
seq
amino acid
sequence
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English (en)
French (fr)
Inventor
David LARGAESPADA
Branden MORIARITY
Beau WEBBER
Neil OTTO
Sandeep Kumar
Leah HOGDAL
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B Mogen Biotechnologies Inc
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B Mogen Biotechnologies Inc
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    • A61K35/48—Reproductive organs
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian

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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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CA3047313A 2016-12-16 2017-12-15 Enhanced hat family transposon-mediated gene transfer and associated compositions, systems, and methods Pending CA3047313A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662435522P 2016-12-16 2016-12-16
US62/435,522 2016-12-16
PCT/US2017/066829 WO2018112415A1 (en) 2016-12-16 2017-12-15 ENHANCED hAT FAMILY TRANSPOSON-MEDIATED GENE TRANSFER AND ASSOCIATED COMPOSITIONS, SYSTEMS, AND METHODS

Publications (1)

Publication Number Publication Date
CA3047313A1 true CA3047313A1 (en) 2018-06-21

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CA3047313A Pending CA3047313A1 (en) 2016-12-16 2017-12-15 Enhanced hat family transposon-mediated gene transfer and associated compositions, systems, and methods

Country Status (10)

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US (5) US11111483B2 (https=)
EP (2) EP3555273B1 (https=)
JP (1) JP7275043B2 (https=)
KR (1) KR102523318B1 (https=)
CN (1) CN110730821B (https=)
AU (1) AU2017378482B2 (https=)
CA (1) CA3047313A1 (https=)
EA (1) EA201991431A1 (https=)
IL (1) IL267334B2 (https=)
WO (1) WO2018112415A1 (https=)

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US20180216087A1 (en) 2018-08-02
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US20180245055A1 (en) 2018-08-30
IL267334B1 (en) 2024-09-01
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AU2017378482A1 (en) 2019-07-11
US20220112472A1 (en) 2022-04-14
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US12037611B2 (en) 2024-07-16
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US20200339965A1 (en) 2020-10-29
US10227574B2 (en) 2019-03-12
EP3555273B1 (en) 2024-05-22
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US11162084B2 (en) 2021-11-02
US20180327726A1 (en) 2018-11-15

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